Cytarabine has been the mainstay for AML treatment for over 50 years. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side-effect. www.nature.com/articles/s41... Work led by Jia-Cheng Liu, Donpeng Wang and Elsa Callen and terrific collaborators!
Mechanism of cytarabine-induced neurotoxicity - Nature
Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less n...
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