Cardiometabolic Multimorbidity and Depressive Symptom Trajectories in middle-aged and older adults with Chronic Pain: Evidence from the CHARLS and ELSA Cohorts

Introduction: The co-occurrence of chronic pain and cardiometabolic multimorbidity (CMM) is increasingly prevalent among middle-aged and older adults, yet the extent to which CMM shapes the longitudi...

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Molecular and Cellular Crosstalk in the Pathogenesis of Diabetic Retinopathy

Diabetic retinopathy (DR) is a major cause of vision loss worldwide and arises from tightly interconnected molecular mechanisms involving oxidative stress, inflammation, apoptosis, and angiogenesis. C...

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Efficacy and Safety of Vonoprazan vs Esomeprazole for Early Symptom Relief in Erosive Esophagitis: A 2-Week, Double-Blind Randomized Trial Using GerdQ

Introduction: This study compared the early symptom relief efficacy and safety of vonoprazan, a potassium-competitive acid blocker (P-CAB), and esomeprazole, a proton pump inhibitor (PPI), in patient...

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The C-reactive protein-albumin-lymphocyte (CALLY) index predicts survival in hepatitis B-related hepatocellular carcinoma after radical resection: a propensity score-matched analysis in a Chinese coho...

Introduction: The C-reactive protein–albumin–lymphocyte (CALLY) index has emerged as a promising prognostic tool in various malignancies, yet its role in patients with hepatitis B virus (HBV)-related...

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The Relationship Between Life’s simple 7 and Generalized Anxiety Disorder: A Study Based on KNHANES and Machine Learning

Introduction: This study aimed to investigate the relationship between LS7 scores and GAD risk in a nationally representative Korean population. Material and methods: This study included 12,366 pa...

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Hemoglobin glycation index as a screening tool for aging acceleration and cardiovascular disease: a population-based study

Introduction: Diabetes promotes aging and contributes to the progression of cardiovascular disease (CVD). Hemoglobin glycation index (HGI) serves as an indicator linking blood glucose to CVD, but the...

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Association between childbirth history and multiple health outcomes

Introduction: To explore the association between childbirth experience and multiple health outcomes, and to discuss the role of blood lipids. Material and methods: The cross-sectional study utiliz...

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Assessment of microbial contamination on mobile phones among medical staff, students, and visitors in a pediatric hematology-oncology ward, and evaluation of its association with nosocomial infections

Introduction: Healthcare-associated infections (HAIs) remain a significant threat to patient safety. The aim of this study was to evaluate the frequency and extent of microbial contamination of cell ...

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C-reactive protein-albumin-lymphocyte (CALLY) index in chronic kidney disease and mortality: insights into inflammation, nutrition, and immune status

Introduction: The C-reactive protein-albumin-lymphocyte (CALLY) index represents a novel composite biomarker integrating inflammatory, nutritional, and immune parameters. We aimed to examine the rela...

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Serum total bile acids are associated with coronary artery calcification as assessed by non‑gated chest computed tomography: a multicenter study

Introduction: Coronary artery calcification (CAC) is a risk factor for cardiovascular disease (CVD). The association between serum total bile acid (TBA) concentration and CAC has not been investigate...

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Long-term prognosis in patients suffering from myocardial infarction with non-obstructive coronary arteries, ST-segment elevation myocardial infarction, infective myocarditis and tako-tsubo cardiomyop...

Introduction: Myocardial infarction with non-obstructive coronary arteries (MINOCA), tako-tsubo cardiomyopathy (TTC), infective myocarditis (IM) and acute ST-segment elevation myocardial infarction ...

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Cognitive screening for cardiovascular risk stratification in stable coronary artery disease: a prospective cohort study

Introduction: While cognitive impairment is prevalent in patients with coronary artery disease (CAD), its prognostic significance in stable CAD patients remains unclear. Material and methods: In t...

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Cross-sectional associations of metabolic risk indices and cardiometabolic multimorbidity among adults with depressive symptoms: evidence from China and the United Kingdom

Introduction: Depression is associated with cardiovascular disease, but the impact of metabolic markers on cardiometabolic multimorbidity (CMM) remains unclear. We examined the atherogenic index of p...

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Thermal imaging of the tongue as an indicator of lipid profile parameters in patients with type 2 diabetes mellitus: a pilot study

Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia and associated carbohydrate, protein, and lipid metabolism disturbances. Poor glycemic con...

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Beyond traditional lipid markers: low-density lipoprotein cholesterol with apolipoprotein B ratio – a novel biomarker for sarcopenia?

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The association of low-density lipoprotein cholesterol with apolipoprotein B ratio and sarcopenia: a cross-sectional study

Introduction: Sarcopenia is increasingly linked to metabolic dysregulation, including dyslipidemia. The low-density lipoprotein cholesterol with apolipoprotein B (LDL-C/ApoB) ratio (LAR), reflecting ...

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The global landscape of non-Hodgkin lymphoma incidence and mortality in 2022 and projections to 2045

Introduction: Updated estimates of the current and future burden of non-Hodgkin lymphoma (NHL) are critical for evaluating global cancer control efforts and addressing disparities in disease impact a...

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Epidemiological trends and burden of osteoarthritis in the United States: insights from the GBD 2021 study

Introduction: This study aimed to analyze the epidemiological trends and burden of osteoarthritis (OA) in the United States (U.S.) from 1990 to 2021 using data from the Global Burden of Disease (GBD)...

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Global burden of aortic aneurysm from high body mass index and systolic blood pressure in older adults: 1990–2021 and projections to 2050

Introduction: Aortic aneurysm is a life-threatening vascular condition with a high case-fatality rate, yet the specific contributions of modifiable risk factors to its burden in the rapidly growing p...

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Hepatitis E virus (HEV) as an emerging challenge in Poland: a narrative review of epidemiological and clinical data

Manuscripts on hepatitis E virus (HEV) epidemiology in Poland indexed in PubMed were analyzed in the context of current clinical and biological knowledge and epidemiological data from other regions of...

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May nutrients and dietary supplements influence the gut-lung microbiota axis in chronic obstructive pulmonary disease and exacerbations?

There is increasing evidence that microbial community structure and diversity are associated with disease severity and clinical outcomes, both in stable chronic obstructive pulmonary disease (COPD) an...

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Shared decision-making in primary care: barriers and facilitators from the physician’s and patient’s perspectives: a scoping review

Introduction: Health-related communication and shared decision-making (SDM) are crucial elements of patient-centered care. The aim of this review was to identify the key barriers and facilitators inf...

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Causal Association Between Circulating Macrophage Inflammatory Protein 1α (MIP-1α) Levels and Eclampsia: A Two-Sample Mendelian Randomization Study

Introduction: Preeclampsia-eclampsia (PE) poses serious risks to maternal and fetal health. Inflammatory markers—such as WBC counts, macrophage-related factors (e.g., serum clusters, MIF, CSF protein...

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MicroRNA-Based Machine Learning Classifier Accurately Predicts Molecular Subtypes in Endometrial Carcinoma

Introduction: Molecular classification of endometrial carcinoma (EC) has revolutionized prognostic stratification. MicroRNAs (miRNAs) offer a potential cost-effective alternative for molecular subtyp...

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Comparative analysis of prostate cancer grade at biopsy versus after radical prostatectomy: a retrospective observational study

Introduction: Accurate Gleason grading is essential for optimal treatment selection in prostate cancer, particularly in patients eligible for active surveillance (AS). This study aimed to assess the ...

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Site-specific PKM2 phosphorylation in Cancer: A systematic review of its role in metabolic plasticity and precision therapy

Pyruvate Kinase M2 (PKM2), a central glycolytic enzyme, plays a key role in tumour metabolism and growth. Its activity is regulated via site-specific phosphorylation at Tyr105, Ser37, and Thr454, affe...

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Long-Term Weight Patterns and Risk of Sarcopenia in Community-Dwelling Older Adults: A Three-Year Cohort Study

Introduction: Static body mass index (BMI) measurements fail to capture the clinical implications of body weight fluctuations. Therefore, this study investigated the association between multi-dimensi...

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Effect of resistance rotational correction manipulation for the knee joint on joint force line and joint temperature in patients with knee osteoarthritis: A randomized controlled trial.

Introduction: Knee osteoarthritis (KOA) is a common chronic degenerative disease in middle-aged and elderly people, characterized by joint pain, functional impairment, and abnormal joint alignment. ...

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Effects of nocturnal-diurnal sleep patterns and social participation factors on memory-related disorders in middle-aged and older adults

Introduction: To investigate whether there is an association between nocturnal-daytime sleep patterns as well as social participation and memory-related categories of diseases in the middle-aged and ...

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Serum TNF-α dynamics under chemoradiation and prognosis in high-grade glial tumors

Introduction: Tumor necrosis factor-alpha (TNF-α) is a mediator of cancer-related inflammation and may affect glioma biology. Clinical information on longitudinal TNF-α dynamics during chemoradiation...

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