Editorial: Stand up to stay healthy?

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Daily sedentary behavior exceeding 5 hours is independently associated with MAFLD: a cross-sectional study from NHANES 2017–2020

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant global cause of chronic liver disease, linked to various health issues. Although sedentary beha...

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Improvement in age- and sex-dependent mortality in patients with atrial fibrillation between 2011 and 2016 – a nationwide retrospective study from Hungary

Introduction: Atrial fibrillation (AF) is associated with a higher risk of mortality; however, detailed analysis on the excess risk of death of patients diagnosed with AF compared to a non-AF populat...

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Preoperative clinical and renal ultrasonography variables associated with systolic and diastolic blood pressure reduction after renal artery stenting

Introduction: The response to stent-assisted angioplasty (PTA) in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) is unpredictable. Therefore, the present study aimed to ident...

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Machine learning prediction of early hypothermia in sepsis patients

Introduction: Sepsis is a systemic inflammatory response syndrome caused by infection and remains a leading cause of mortality worldwide. Abnormal body temperature, especially hypothermia (body tempe...

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Comparison of ChatGPT and Claude in managing real-life difficult nephrology cases

Introduction: Artificial intelligence (AI)-based large language models (LLMs) are promising tools for clinical decision support, but their clinical performance in specialized fields such as nephrolog...

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A meta-analysis of the efficacy of four antidepressants combined with common opioid analgesics in the treatment of cancer-related neuropathic pain

Introduction: The aim of the study was to conduct a meta-analysis evaluating the efficacy of four antidepressants combined with commonly used opioid analgesics for the treatment of cancer-related neu...

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Associations between enlarged perivascular spaces and clinical manifestations: a meta-analysis

Introduction: Enlarged perivascular spaces (EPVS) are ubiquitous in the elderly and have an insidious onset. Their correlation with clinical symptoms is easily overlooked and controversial. We conduc...

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Patients at high risk of postoperative complications in Crohn’s disease: a meta-analysis and systematic review

Introduction: The aim of the study was to identify patient-related factors influencing the risk of early postoperative complications in Crohn’s disease (CD). Material and methods: A meta-analysis ...

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Beyond muscle: could GLP-1 receptor agonists offset the tendon risk of intensive lipid-lowering therapy?

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GLP-1 receptor agonists and tendon healing: a systematic review and meta-analysis

Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are prescribed for cardiometabolic indications and may exert anti-inflammatory and tissue-regenerative effects. However, their effec...

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Assessment of microbial contamination of mobile phones among medical staff, students, and visitors in a pediatric hematology-oncology ward and its relationship with infections among pediatric patients

Introduction: Healthcare-associated infections (HAIs) remain a significant threat to patient safety. The aim of this study was to evaluate the frequency and extent of microbial contamination of cell ...

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The unequal burden of interstitial lung disease mortality in older US adults: a 22-year analysis and projections to 2030

Introduction: Interstitial lung disease (ILD) comprises a heterogeneous group of disorders characterized by progressive lung fibrosis, respiratory failure, and substantial mortality, particularly amo...

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Association between childbirth history and multiple health outcomes

Introduction: The aim of the study was to investigate the association between childbirth experience and multiple health outcomes, and to discuss the role of blood lipids. Material and methods: The...

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Temporal trends and decomposition analysis of cardiovascular disease burden in China and worldwide from 1990 to 2021, with projections to 2036

Introduction: Cardiovascular disease (CVD) is a major public health concern, and its burden and trends require further clarification. This study aimed to compare the CVD burden between China and the ...

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Association between iron levels and the risk of type 2 diabetes mellitus: NHANES 2009−2018 and Mendelian randomization study

Introduction: The association between serum iron levels and type 2 diabetes mellitus (T2DM) remains unclear. Material and methods: In total, 19,483 participants from the National Health and Nutrit...

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Association of AT1R-Mediated TGF-β1/Smad Axis Downregulation with Antifibrotic and Functional Benefits of Extended Exercise After Myocardial Infarction

Introduction: Exercise training has cardioprotective effects after myocardial infarction (MI), but the associated molecular pathways remain incompletely defined. The novel aspect of this work is the...

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Headaches, hormones, and transgender population: current evidence and knowledge gaps.

Migraine is a prevalent primary headache disorder affecting 14–17% of the global population and is strongly influenced by sex hormones. However, its characteristics in transgender individuals remain p...

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Glucose Regulation States and Renal Outcomes in Patients with Preserved Kidney Function

Introduction: We investigated the associations between glucose regulation states and the risks of adverse renal outcomes and all-cause mortality in a large outpatient population. Material and metho...

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FTY720 attenuates LPS-induced acute lung injury through PP2A- tristetraprolin–dependent anti-inflammatory signaling

Introduction: Acute lung injury (ALI) is characterized excessive inflammatory signaling and uncontrolled cytokine production. Tristetraprolin (TTP) is a key post-transcriptional regulator of inflamma...

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Cardiometabolic Multimorbidity and Depressive Symptom Trajectories in middle-aged and older adults with Chronic Pain: Evidence from the CHARLS and ELSA Cohorts

Introduction: The co-occurrence of chronic pain and cardiometabolic multimorbidity (CMM) is increasingly prevalent among middle-aged and older adults, yet the extent to which CMM shapes the longitudi...

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Molecular and Cellular Crosstalk in the Pathogenesis of Diabetic Retinopathy

Diabetic retinopathy (DR) is a major cause of vision loss worldwide and arises from tightly interconnected molecular mechanisms involving oxidative stress, inflammation, apoptosis, and angiogenesis. C...

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Efficacy and Safety of Vonoprazan vs Esomeprazole for Early Symptom Relief in Erosive Esophagitis: A 2-Week, Double-Blind Randomized Trial Using GerdQ

Introduction: This study compared the early symptom relief efficacy and safety of vonoprazan, a potassium-competitive acid blocker (P-CAB), and esomeprazole, a proton pump inhibitor (PPI), in patient...

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The C-reactive protein-albumin-lymphocyte (CALLY) index predicts survival in hepatitis B-related hepatocellular carcinoma after radical resection: a propensity score-matched analysis in a Chinese coho...

Introduction: The C-reactive protein–albumin–lymphocyte (CALLY) index has emerged as a promising prognostic tool in various malignancies, yet its role in patients with hepatitis B virus (HBV)-related...

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The Relationship Between Life’s simple 7 and Generalized Anxiety Disorder: A Study Based on KNHANES and Machine Learning

Introduction: This study aimed to investigate the relationship between LS7 scores and GAD risk in a nationally representative Korean population. Material and methods: This study included 12,366 pa...

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Hemoglobin glycation index as a screening tool for aging acceleration and cardiovascular disease: a population-based study

Introduction: Diabetes promotes aging and contributes to the progression of cardiovascular disease (CVD). Hemoglobin glycation index (HGI) serves as an indicator linking blood glucose to CVD, but the...

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Association between childbirth history and multiple health outcomes

Introduction: To explore the association between childbirth experience and multiple health outcomes, and to discuss the role of blood lipids. Material and methods: The cross-sectional study utiliz...

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Assessment of microbial contamination on mobile phones among medical staff, students, and visitors in a pediatric hematology-oncology ward, and evaluation of its association with nosocomial infections

Introduction: Healthcare-associated infections (HAIs) remain a significant threat to patient safety. The aim of this study was to evaluate the frequency and extent of microbial contamination of cell ...

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C-reactive protein-albumin-lymphocyte (CALLY) index in chronic kidney disease and mortality: insights into inflammation, nutrition, and immune status

Introduction: The C-reactive protein-albumin-lymphocyte (CALLY) index represents a novel composite biomarker integrating inflammatory, nutritional, and immune parameters. We aimed to examine the rela...

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Serum total bile acids are associated with coronary artery calcification as assessed by non‑gated chest computed tomography: a multicenter study

Introduction: Coronary artery calcification (CAC) is a risk factor for cardiovascular disease (CVD). The association between serum total bile acid (TBA) concentration and CAC has not been investigate...

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