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Piel Lab

@piellab.bsky.social

Official account of the Piel Lab - Bacterial Natural Products in ETH https://micro.biol.ethz.ch/research/piel.html

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Piel Lab@piellab.bsky.social · 5mo ago

Now at @nature.com ! Our collab with the Sunagawa lab reveals coral reef microbiomes as a new reservoir for natural product discovery 🪸, and we functionally characterized novel RiPP chemistry and enzymology hidden within these reefs. Congrats Daniel, Dora, Alena, and Clara on this amazing work!

Coral microbiomes as reservoirs of unknown genomic and biosynthetic diversity - Nature

Reconstructing microbial genomes from 820 reef-building corals collected at 99 reefs across 32 islands throughout the Pacific Ocean highlights the importance of conserving coral reefs as vital reservo...

nature.com

Piel Lab@piellab.bsky.social · 6mo ago

Out now in Chem! 🧪 Origamins: hypermodified cryptic peptides with extraordinary structures found in >1000 BGCs including human-associated bacteria. With potent cytotoxicity they raise fascinating questions about their role in the human microbiome. Huge congrats to the team and collaborators!🥂

Widespread hypermodified β-helical peptides in common bacteria

Vadakumchery, Meier, Forneris, et al. report a family of β6.3-helical ribosomal peptides that occurs in phylogenetically diverse and well-known bacteria. Their study provides insights into the structu...

cell.com

Piel Lab@piellab.bsky.social · 9mo ago

Happy to share work by Maria and awesome collaborators published in Nature Chem Bio! Using metagenomic, single-bacterial, and biochemical methods we provide insights into uncultivated bacterial symbionts as rich sources of bioactive natural products in marine sponges. #DrugDiscovery #NaturalProducts

Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges - Nature Chemical Biology

Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...

nature.com