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It's interesting that fentanyl uses two separate neural pathways to make it the most addictive drug known to man - one to make it pleasurable, and the other to make withdrawal horrible: nature.com/articles/s41... @Nature #InMice #Fentanyl #Opiod #Addiction
Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement - Nature
Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifyi...
nature.com
