New in Nature Aging: @cuanschutz.bsky.social researcher @bstranger.bsky.social collaborates on report about how sex differences shape health and aging across the lifespan. This highlights how big data and AI can improve sex-aware risk prediction and personalized medicine ➡️ https://cudbmi.info/nia-1

AI agents are gaining significant attention in science—but what exactly distinguishes an 'AI agent' from chatbots and other tools? Expert researchers and software engineers at @cuanschutz.bsky.social gave us the story ➡️ https://cudbmi.info/ai-scientists-1

How can we get more useful feedback from software users? Researchers at @cuanschutz.bsky.social developed LadderTeam, an LLM framework that probes vague survey responses for actionable feedback. They’ll present LadderTeam tonight at the ACM AI Summit. Learn more: https://cudbmi.info/ladderteam-1

LLMs offer promise for collecting Social Determinants of Health data at-scale, but evaluation methods are needed. @cuanschutz.bsky.social researchers, including biomedical researcher James Mitchell, PhD, developed a rubric and iterative evaluation approach. Learn more ➡️ https://cudbmi.info/sdoh-1

Researchers in the Way Lab at @cuanschutz.bsky.social, led by biomedical researcher Greg Way, develop and leverage open-source tools to help discover new therapeutics for diseases with unmet need.  Learn more about their suite of open-source tools in our newsroom ➡️ https://cudbmi.info/cyto-1

The Way Lab at @cuanschutz.bsky.social seeks to uncover new therapeutics for diseases with unmet need.  The team develops open-source software to efficiently evaluate thousands of compounds, helping to find the best candidates for future research. Learn more ➡️ https://cudbmi.info/cyto-1

A new study published in the Gut Microbes journal, led by researchers in the Stanislawski Lab at @cuanschutz.bsky.social, evaluated multi-omic data to uncover features that correlate with individual responses to weight loss efforts. Learn more ➡️ https://cudbmi.info/multi-omic-bmi-1

A study by a team including @cuanschutz.bsky.social researcher Tell Bennett, MD, evaluated Acute Kidney Injury (AKI) risk prediction models in pediatric critical care. The study found that incorporating multi-center data improved model prediction performance ➡️ https://cudbmi.info/aki-model-1

A new study published in @gigascience.bsky.social, led by researchers at @cuanschutz.bsky.social, introduces KG-Microbe: a knowledge graph (KG) framework that harmonizes and standardizes microbial data to support microbiome research. Learn more here ➡️ https://cudbmi.info/kg-microbe-1

What a fantastic week at #ISMB2026 in Washington, D.C. Our DBMI team from @cuanschutz.bsky.social was well represented, with researchers delivering talks, showcasing posters and facilitating panels throughout the week. Thanks to everyone who connected, collaborated and shared their work.

Congratulations to Aishwarya Mandava, researcher in the Krishnan Lab at @cuanschutz.bsky.social, for winning the TransMed COSI Best Poster Award at #ISMB2026 🎉

Final day of #ISMB2026 DBMI has oral presentations from Samantha Lopez Alvarez plus poster presentations from Kewalin Samart, Abhirupa Ghosh and Evan Brenner. Plus visit our booth from 10:00 a.m.–4:40 p.m. Get the details here: https://cudbmi.info/ismb-2026-1

Wednesday at #ISMB2026 Don't miss oral presentations from Emma Lathouwers, Lucas Gillenwater, Evan Brenner, Katerina Terwelp, and Akshay Kumar Avvaru. Plus, visit DBMI’s booth from 10 a.m.–4:40 p.m. Get the details here: https://cudbmi.info/ismb-2026-1

DBMI has a full Tuesday at #ISMB2026 Visit our booth from 10:00 a.m.–4:40 p.m., explore posters from Lucas Gillenwater and Abhirupa Ghosh, and attend Mónica Muñoz Torres’ open science panel. Get the details here: https://cudbmi.info/ismb-2026-1

Day 2 at #ISMB2026 DBMI’s booth is open today from 10:00 a.m.–4:40 p.m. in the Columbia Ballroom. Come meet our researchers and learn more about biomedical informatics at CU Anschutz. Check out our booth schedule and ISMB Research Showcase here: https://cudbmi.info/ismb-2026-1

We're kicking off #ISMB2026 in Washington, D.C. Stop by our booth in the Columbia Ballroom today from 4:00–9:00 p.m. to connect with our researchers and learn more about our department. Check out our presenter schedule, booth schedule and ISMB Research Showcase here: https://cudbmi.info/ismb-2026-1

Can AI say "I don't know"? Although Large Language Models (LLMs) have come a long way, they still struggle with declaring uncertainty—a vital task in clinical settings. Read more in the perspective led by @cuanschutz.bsky.social researcher Andrea Sikora, PharmD➡️ https://cudbmi.info/can-ai-say-idk-1

Researchers @cuanschutz.bsky.social conducted a study in Zimbabwe exploring links between immune function, microbiome, diet and other lifestyle factors for people living with HIV. The team uncovered links that may inform healthcare interventions. Learn more➡️ https://cudbmi.info/zimbabwe-diet-hiv-1

Research in Zimbabwe Is Shedding Light on How Diet Can Impact the Health of People Living With HIV

Researchers conducted a study in Zimbabwe exploring links between immune function, microbiome, diet and other lifestyle factors for people living with HIV.

cudbmi.info

A new EHR-based approach to pediatric sepsis surveillance shows strong validity and reveals a substantial burden: ~18,000 cases and 1,800 deaths annually in the US, with no significant decline over time.

National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data

This cohort study assesses US incidence, mortality, and trends of sepsis in nonneonatal children using a Pediatric Sepsis Event (PSE) definition adapted from the 2024 Phoenix criteria for scalable ele...

cudbmi.info

As healthcare systems expand digital tools, research is raising an important question: who gets left behind? Samantha Stonbraker’s work shows that designing for diverse digital and health literacy levels improves usability, engagement, and outcomes.

Designing Digital Health Tools That Work for Everyone

As healthcare moves online, researchers examine how inclusive design can improve digital health tools and reduce disparities for underserved populations.

cudbmi.info

New findings in glioblastoma treatment: bavituximab combined with chemoradiotherapy demonstrated encouraging survival and reduced tumor immunosuppression, with biomarkers that may help identify responders.

Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients

AbstractPurpose:. We evaluated the efficacy of bavituximab—a mAb with anti-angiogenic and immunomodulatory properties—in newly diagnosed patients with glioblastoma (GBM) who also received radiotherapy...

cudbmi.info

New multicenter analysis: early albumin administration in pediatric sepsis was linked to improved survival in patients with septic shock, with no benefit seen in non-shock cases. Highlights the importance of patient selection.

Association of Albumin Infusion With Differential Response... : Pediatric Critical Care Medicine

h record data collected from 13 U.S. PICUs between 2012 and 2018, consisting of children younger than 18 years who met Phoenix sepsis criteria within the first 24 hours of PICU admission. Interventions: Covariate-balancing propensity score weighting was...

cudbmi.info

Retinal imaging may offer more than eye screening. This study shows ROP images, combined with clinical data, can help predict BPD and pulmonary hypertension in preterm infants—supporting earlier, noninvasive detection.

Cardiopulmonary Disease in Retinal Images of Premature Infants

This diagnostic study investigates if an artificial intelligence algorithm can diagnose bronchopulmonary dysplasia or pulmonary hypertension in the retinal images of preterm infants obtained during re...

cudbmi.info

The medicalcoder R package supports running comorbidity algorithms on datasets—even those with ICD-9 and ICD-10 codes. Today, developer @peteredewitt.bsky.social is presenting medicalcoder at the virtual R/Medicine 2026 conference at 2:06 p.m. ET. Learn more here➡️ https://cudbmi.info/medcoder-1

New study on hydrocortisone use in critically ill children: early treatment was linked to improved vasoactive inotropic scores in the PICU, but not in the CVICU. Important implications for practice and future research.

Frontiers | Change in vasoactive inotropic score following hydrocortisone administration in the pediatric intensive care unit: a PICU data collaborative study, 2010–2022

ObjectiveHydrocortisone (HCT) is an ancillary therapy for children with refractory hypotension. Current guidelines for HCT use are non-specific due to limite...

cudbmi.info

New multicenter study uses image-based metrics to quantify retinal vascularization in ROP. Nasal extent was consistently lower than temporal, with high accuracy for zone I diagnosis—supporting more objective classification.

Quantitative Assessment of the Extent of Retinal Vascularization in Retinopathy of Prematurity

To evaluate pixel-based measurements of the minimum nasal and temporal extent of retinal vascularization (NERV and TERV) from RetCam images in retinopathy of prematurity (ROP).

cudbmi.info

AI is rapidly entering clinical decision-making—but careful evaluation is key. This paper introduces the ABCDEFG framework to help clinicians critically assess AI tools before adoption into practice.

Frontiers | ABC’S of AI: proposing a clinician’s framework for the interpretation of artificial intelligence studies

Artificial intelligence (AI) and machine learning have emerged as transformative analytic methods capable of identifying patterns and proposing treatment str...

cudbmi.info

Emily Meyer, PhD, and James Mitchell, PhD will be presenting a poster at NORDP. The Facilities and Resources Generator, highlights a software tool that streamlines how facilities and resources sections are created for grant proposals. 🗓️ April 28, 2026 | 12:45–2:00 PM ET 📍 Exhibit Hall, JW Marriott

New research suggests dietary fiber may protect against severe C. difficile infection. Low-fiber diets were linked to higher mortality and sepsis, while fiber supplementation improved outcomes in a preclinical model.

Dietary fiber reduces mortality from secondary sepsis in a murine model of Clostridioides difficile infection

Health sciences; Biological sciences; Systems biology; Diet

cudbmi.info

High-altitude pregnancy offers insight into human adaptation. This study connects fetal genetics with placental metabolism, identifying metabolic signatures tied to preeclampsia and fetal growth in Andean populations.

Dysregulated Fatty Acid Metabolism in Preeclampsia Among Highland Andeans: Insights Into Adaptive and Maladaptive Placental Metabolic Phenotypes

Multi-omic profiling of highland Andeans reveals adaptive fetal haplotypes associated with favorable placental metabolic phenotypes, while preeclampsia is marked by dysregulated fatty acid oxidation ...

cudbmi.info