Very nice discovery from the Jackson, Bravo and Basel labs. Cleaved tRNA ends, loaded with an amino acid, activate a form of bacterial immunity

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · yesterday

Aminoacylated tRNA tails trigger auxiliary bacterial immunity https://www.biorxiv.org/content/10.64898/2026.10.14.759216v1

So many bacterial genomes are being edited… Could we spot them in the wild even without obvious markers??? Worry not! Our @EdanGabay has you covered. In our new preprint, she pinpoints such genes disrupting the natural genomic "grammar": www.biorxiv.org/content/10.6... 1/4

It annoyed us that annotation tools aren't great at saying "I just don't know". That's a real problem for metagenomes and non-model organisms, where it usually means picking some threshold and hoping for the best. We built FAMUS to try and fix this. doi.org/10.64898/202... 1/8

FAMUS: A Few-Shot Learning Framework for Large-Scale Protein Annotation

Predicting gene function is a pivotal and challenging step in genomic and metagenomic data analysis. Current automatic annotation tools typically rely on the single most similar sequence from the quer...

doi.org

Now available in bioinformatics! Congrats Ella 🎉

Burstein lab@bursteinlab.bsky.social · 8mo ago

🧬 New preprint alert! Protein language models have transformed biology - but what about the tokens they read? In our new preprint, 👑@EllaRannon👑 studies how tokenization choices shape pLM performance and efficiency. 🧵 (1/5) www.biorxiv.org/content/10.6...

🧬 New preprint alert! Protein language models have transformed biology - but what about the tokens they read? In our new preprint, 👑@EllaRannon👑 studies how tokenization choices shape pLM performance and efficiency. 🧵 (1/5) www.biorxiv.org/content/10.6...

How do you kill a MRSA superbug armed with 15 different anti-phage defense systems? You make a smarter phage. Check out our latest preprint on overcoming bacterial immunity using defense-guided engineering to build durable therapeutic phage cocktails! Led by Sarah Voss. doi.org/10.64898/202...

🧬 New preprint alert! Protein language models have transformed biology - but what about the tokens they read? In our new preprint, 👑@EllaRannon👑 studies how tokenization choices shape pLM performance and efficiency. 🧵 (1/5) www.biorxiv.org/content/10.6...

1/4 Ever wanted to predict bacterial protein-protein interactions (PPI) on a large scale? We wanted to, but realized there’s no such algorithm that is both rapid and optimized for bacterial protein analysis. This led our ⭐️Chen Agassy⭐️ to develop B-PPI: doi.org/10.64898/202...

1/6 🧬📊 Curious about the buzz around NLP in biology? Feeling overwhelmed by the rapid developments? We've got you covered! Our review on NLP applications in genomics, by the wonderful Ella Rannon, is now out as a pre-print! #NLP #Bioinformatics arxiv.org/abs/2506.02212

Hello Bluesky! Burstein lab just joined - are we too late for the party 👀 ??