Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...

Exciting work @blurtonjoneslab.bsky.social: CRISPR-engineered iPSC-microglia use the plaque-responsive CD9 promoter to deliver Aβ-degrading neprilysin across the brain-- reducing plaques, inflammation & synaptic loss. A promising new cell therapy platform for AD www.sciencedirect.com/science/arti...

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com

This amazing news made my week! 🎊 I’m beyond blessed to be part of the @brightfocus.bsky.social community while studying the protective microglial responses in the context of Alzheimer’s disease. Super thankful to @blurtonjoneslab.bsky.social and the entire MBJ team for their continuous support!

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease @cp-cellstemcell.bsky.social sciencedirect.com/science/article/pii/S1934590925000992

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com

Congratulations to Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍 www.sciencedirect.com/science/arti...

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com

This message needs to be heard widely.

NIH funding delivers exponential economic returns — Harvard Gazette

Report finds all 50 states reap gains in patient health, job creation, research resources, business development.

news.harvard.edu

Another fave

At @standupforscience.bsky.social and the signs are statistically significantly excellent

@baldwin.senate.gov released a press release calling out the administration for damaging the Alzheimer's Disease Research Center network through it's screwing up NIH processes. www.baldwin.senate.gov/news/press-r... 1/2

Baldwin Blasts Trump Administration for Stopping $65 Million for Alzheimer’s Disease Research | U.S. Senator Tammy Baldwin of Wisconsin

WASHINGTON, D.C. – Today, U.S. Senator Tammy Baldwin (D-WI), Ranking Member of the Senate...

baldwin.senate.gov

Nice to see this finally published! Congratulations @jack-humphrey.bsky.social www.nature.com/articles/s41... (Collaborative work with Panos Roussos and his team! ) Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics

This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

nature.com

Elon Musk and his 19-year-olds have now disrupted the approval of medical devices that save lives. Every member of Congress bears a responsibility to stop this right now.

Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction. We all need to speak out to save lives.

The Senate HELP Committee has jurisdiction over NIH. GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC. Research universities and hospitals in those states need to be extra loud.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants. grants.nih.gov/grants/guide...

This is a full on assault on education. The US is the world leader in innovation research, technology only because we as a society support it. Without support for world leading research, we will brain drain and the best and brightest will go where research thrives www.statnews.com/2025/02/07/n...

NIH plans to slash support for indirect research costs, sending shockwaves through science

The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%

statnews.com

Un-fucking-believable. I have... no words. This is how you destroy science and also public health.

Announcemets on Fridays are meant to fly under the radar. Cutting NIH indirect rates to 15% signal the beginning of the end for a strong US biomedical research enterprise. We need to form strong partnerships with foundations/philantropy and pharma and circle the wagons grants.nih.gov/grants/guide...

Cool work the Lance Johnson’s lab on lipid droplet proteome and APOE! @johnsonlab.bsky.social @morganti.bsky.social @cohenlaboratory.bsky.social www.biorxiv.org/content/10.1...

APOE4 alters the lipid droplet proteome and modulates droplet dynamics

Excess lipid droplet (LD) accumulation is associated with several pathological states, including Alzheimers disease (AD). However, the mechanism(s) by which changes in LD composition and dynamics cont...

biorxiv.org

new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

New publication on Cell Reports! We describe a mechanism by which #microglia degrade amyloid-beta deposits that they can't phagocytose. Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell. www.sciencedirect.com/science/arti...

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that …

sciencedirect.com

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1

In vivo veritas "We identify differences in the protein content of ex vivo and in vitro cells and significant proteome differences associated with protein synthesis, metabolism, microglia marker expression, and environmental sensors." www.cell.com/cell-reports...

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Lloyd et al. generated a comprehensive microglia proteome database, identifying over 11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated with protein synthesis, ...

cell.com

In #neuroinflammation, lineage matters….check out this preprint of long term engraftment of blood derived- #macrophages vs brain resident #microglia in #TBI # neuroskyence

bioRxiv Immunology@biorxiv-immuno.bsky.social · 2y ago

Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury https://www.biorxiv.org/content/10.1101/2024.11.18.624186v1

✨Researchers, share your work at #APOE25, Mar. 17-18 in Miami or online. This topic-specific addition to #AAICAdvancements features the latest on the role of APOE & lipid biology in neurodegenerative diseases. Abstracts due 12/2. buff.ly/4eyHVlT

AAIC Advancements: APOE & Lipid Biology | alz.org

Neuroscience researchers should attend this Alzheimer's Association conference to discuss the role of APOE & lipid biology in neurodegenerative diseases.

alz.org

Super excited about this new paper with Vivek Swarup and Kim Green at UCI (hope they both join Bluesky!) - Here we present a spatial transcriptomic (ST) and single-nucleus transcriptomic survey of late-onset sporadic AD and AD in Down syndrome (DSAD)! www.nature.com/articles/s41...

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease - Nature Genetics

Spatial and single-nucleus analyses in human postmortem Alzheimer’s disease (AD) brain tissues at early and late stages from individuals with and without Down syndrome, as well as in AD mouse models, ...

nature.com

Super excited for this!!! Call for abstracts and registration for the #gliameeting in #Marseille starts on 10 December! Learn more about the topics, submission process and the available stipends on the #glia2025 website: loom.ly/AJI_q_Y Submit your abstract by midnight CET on 5 February 2025!