OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity - The EMBO Journal

Hepatic inflammation and immunosurveillance play major roles in the progression of liver cancer. A common trigger for hepatic inflammation is oxidative stress, which stems from mitochondrial dysfuncti...

link.springer.com

T cell control of the intestinal barrier and gut microbiota during ageing

The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction of T cells could disturb host–microbiota symbiosis and the physical integrity of the intestinal barrier, ultimately driving inflammageing and poor health outcomes. Finally, we propose microbiota- and T cell-based therapeutic interventions aimed at strengthening the intestinal barrier to promote healthier longevity. Namely, we discuss the transplantation of youthful microbiota, the use of designed probiotics, and the adoptive transfer of competent or engineered T cells.

dlvr.it

Butyrate extends health and lifespan in mice with mitochondrial deficiency - Nature Communications

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in associatio...

nature.com

Butyrate extends health and lifespan in mice with mitochondrial deficiency - Nature Communications

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in associatio...

nature.com

Una molécula de la microbiota intestinal prolonga la supervivencia de ratones con enfermedades mitocondriales - Centro de Biología Molecular Severo Ochoa

Un estudio en ratones del Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM) revela que el mal funcionamiento de las mitocondrias —las estructuras celulares encargadas de producir energía— alte...

cbm.uam.es

Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV

PPARγ downregulation in colonic CD8+ T cells from people with HIV (PWH) on antiretroviral therapy (ART) disrupts lipid metabolism and promotes contact-dependent epithelial apoptosis, leading to intest...

cell.com

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging

Nature Aging - T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate...

rdcu.be

Descubren un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades múltiples - Centro de Biología Molecular Severo Ochoa

La pérdida de función de los linfocitos T CD4 altera la microbiota intestinal y, en consecuencia, acelera el envejecimiento celular y aumenta el riesgo de enfermedades múltiples. Es lo que […]

cbm.uam.es

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

doi.org

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

science.org

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

science.org