Supper happy to see this published. In short, we show how dendrites and inhibition allow neural circuits to learn new representations while protecting representations that are already stored in the network. See below for a detailed post by @cmiehl.bsky.social: www.sciencedirect.com/science/arti...

Distinct prefrontal-amygdala connectivity drives consolidated fear memories https://www.biorxiv.org/content/10.64898/2026.08.14.744891v1

What regulates the urge to sleep? William Joo and colleagues identified brain regions that reflect how long mice have been awake. Strikingly, inhibiting one of these regions reduces sleep by 70%, without the major behavioral deficits associated with sleep deprivation. www.nature.com/articles/s41...

Wake-activated neuronal populations that regulate sleep drive - Nature

Whole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently red...

nature.com

Yale Neuroscience 🧠 @yaleneuro.bsky.social is hiring this year! We have 2 searches, one cell/molecular/systems neuro (apply.interfolio.com/190736) and one computational neuro (apply.interfolio.com/190740). Got questions about the searches, the department, or the process? Please ask, happy to chat!

I am proud of this paper. Since it came out in 2022 it has received 0 citations (yes that's a zero). But multiple young scientists have found it useful! (from other labs, so they were not coerced...). Perhaps you will find it useful too? SOME TIPS FOR WRITING SCIENCE doi.org/10.1523/ENEU...

Some Tips for Writing Science

When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...

doi.org

A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time. biorxiv.org/content/10.6...

Neuroscience hasn’t been able to investigate the role of astrocytes in memory because “all the tools we have to understand how the brain works are related to neurons." #neuroskyence By @davidbrz.bsky.social www.thetransmitter.org/memory/are-p...

Are parts of the memory trace found in the ‘astroengram?’

Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.

thetransmitter.org

Reshaping cortical circuits through stimulation is an emerging therapy for restoring cognitive function. Here find that stimulation strengthens cell assemblies, which is linked to cell-type-specific gene regulation @nature.com @konopkalab.bsky.social www.nature.com/articles/s41...

Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work!

Nature Methods@natmethods.nature.com · 4w ago

An Analysis from @ptrrupprecht.bsky.social et al investigates the behavior of GCaMP8 variants in spike inference using different algorithms. www.nature.com/articles/s41...

The Cellular and Synaptic Actions of Dopamine During Behavior https://www.biorxiv.org/content/10.64898/2026.08.05.742858v1

For a neural circuit to be "specialized", does it need specialized neurons? In our new work - now out in @NatureNeuro - we address this question in the BLA, using representational geometry to propose a new population-centric way of defining circuit specialization. 🧵👇 1/

🎉 this paper is now out - we show how subicular plateaus are linked to reward locations. Congratulations to the whole team! www.cell.com/cell-reports...

Subicular plateaus signal reward locations during goal-directed behavior

Using in vivo whole-cell recordings during goal-directed navigation, Bhatia, Adel, and Grienberger identify plateaus as a prominent feature of subiculum activity. These events preferentially occur nea...

cell.com

Christine Grienberger@cgrienberger.bsky.social · 7mo ago

🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...

Structural plasticity of the axon initial segment is important for the regulation of neuronal activity. Some recent thoughts on how AIS plasticity may shape learning and memory in neuronal circuits in health and disease: doi.org/10.1016/j.co...

🧠New preprint! We identify minimal circuit motifs that generate diverse selectivity to support categorization, comparison, and decision-making. Trained RNNs converge on the same motifs, revealing principles that link connectivity to computation. @mpinb.mpg.de www.biorxiv.org/content/10.6...

Structured connectivity for structured sequential computations

Cortical computations emerge from the coordinated activity of recurrent neural circuits and are often described through population dynamics and neuronal selectivity. However, how the backbone of the c...

biorxiv.org

4/6 This is where we were surprised: we built Nyx for our lab, it generalised well beyond it. The same pipeline worked across mice 🐭, rats 🐀, humans 🧑, a jackdaw 🐦 and a tegu lizard 🦎. Across early development through ageing. Across different brain regions and intracranial recordings.

🌙 Our new preprint is out! We present Nyx, an open-source unsupervised framework for sleep scoring across species, lifespan and modalities. Validated on 19 datasets and 8,000 hours of sleep, from mice to humans, lizards and birds, across development, ageing, health and disease.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last mo.

Nyx: a flexible framework for sleep scoring across species, lifespan and modalities https://www.biorxiv.org/content/10.64898/2026.07.24.740558v1

The final version of our amygdala dopamine paper is out! BLA dopamine dynamically tracks emotional salience and not value or reward prediction error. Congrats to Dr. Megan Brickner!! www.nature.com/articles/s41...

Basolateral amygdala dopamine transmits emotional salience - Nature Communications

The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...

nature.com

light-activated tetanus neurotoxin (LATeNT) by the @aliceyting.bsky.social lab. Includes a comparison with the light-switchable PdCO (www.nature.com/articles/s41...), showing a long lasting inhibition for 1h hour post illumination. www.nature.com/articles/s41...

Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo - Nature Methods

LATeNT is a light-activatable form of tetanus neurotoxin that can be used for spatiotemporally precise inhibition of exocytosis in neurons and other cells. It can inhibit synaptic transmission in vivo...

nature.com

Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.07.29.741555v1

But What Behavior? arxiv.org/abs/2607.28898

But What Behavior?

What is a natural behavior? I argue that the study of natural behaviors is often the study of the spontaneous behaviors of animals placed in quantifiably different environments. For behavioral general...

arxiv.org

Finally out in @natneuro.nature.com! A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work! www.nature.com/articles/s41...

🎉 *extremely* excited to share our human single neuron + movie dataset is out in #ScientificData! 📄 Human neuron activity during an 83-minute movie from 2,286 neurons and 29 patients 🔗https://www.nature.com/articles/s41597-026-07955-0 1st public dataset from @humansingleneuron.bsky.social!🧵

Today in @natneuro.nature.com, researchers led by @felsenberg.bsky.social report that memories can persist as silent traces, recoverable with the right reminder. But misleading cues can distort recall and create false memories—showing how remembering can rewrite the past. www.fmi.ch/news-events/...

Forgotten memories can leave silent traces in the brain

A forgotten memory is not always a vanished one. FMI neuroscientists investigating the fruit fly brain found that some memories become inaccessible while leaving a silent trace behind. The right remin...

fmi.ch

Pyramidal cells in the cortex send a long apical dendrite to layer 1. What is its role? What happens when it's gone? ✂️ A causal spatial role for apical dendrites in the cortex Out today with @kenneth-harris.bsky.social, @carandinilab.net and @fedrossi.bsky.social www.biorxiv.org/content/10.6...

A causal spatial role for apical dendrites in the cortex

Cortical pyramidal neurons project a long apical dendrite to layer 1 (L1), to receive synaptic inputs that are thought to provide contextual and possibly suppressive modulation. In visual cortex, thes...

biorxiv.org

Registration now open for our AIS meeting, organised with @royalsociety.org in Edinburgh, 7th-8th December 2026! royalsociety.org/science-even...

Neuropixels 1536 Channel Quad Base probe reveals brain-wide communication underlying flexible sensorimotor sequences https://www.biorxiv.org/content/10.64898/2026.07.23.740388v1

Sensing your body (‘Interoception’) is everywhere in theories of mental health. But when we tested how well hundreds of people sensed their heart and lungs, the link to symptoms was almost nowhere to be found. 💣 🚨New @natmentalhealth.nature.com paper 🚨🎉 asks why 🧵 www.nature.com/articles/s44...

Cortex-wide representational drift of different layers https://www.biorxiv.org/content/10.64898/2026.07.15.738614v1

Nice Claude skill to create basic neuroanatomical visualisations with BrainGlobe & blender: github.com/SamedVossber... The single prompt "Use the allen mouse brain atlas to create an animation to show primary visual cortex and primary motor cortex" gives:

From a great collaboration with @lorenzoposani.com, @shuqiw.bsky.social, Samuel Muscinelli, Liam Paninski, now in Nature: www.nature.com/articles/s41...

Rarely categorical, highly separable representations along the cortical hierarchy - Nature

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

nature.com