Safety, feasibility, and preliminary clinical outcomes of psilocybin-assisted therapy for veterans with severe, treatment-resistant PTSD: an open-label pilot clinical trial - Communications Medicine

Armstrong et al. conducted an open-label pilot trial of psilocybin-assisted therapy in U.S. military veterans with severe treatment-resistant PTSD. The therapy was safe and well-tolerated and produced large reductions in PTSD symptoms, with most participants achieving clinical response and remission.

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Exploring automated plasma phospho-tau217 assays for the diagnosis of Down syndrome-related Alzheimer’s disease - Communications Medicine

Schlachetzki et al. explore plasma p-tau217 measures in predicting elevated brain amyloid in 39 people with Down syndrome using two fully automated assays. The initial results suggest high accuracy of plasma p-tau217 and its composite measures in predicting amyloid-PET status with two different platforms.

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Sex Hormones and Hormone Therapy Across Life Course

This Collection aims to expand our understanding of the biology, epidemiology, and clinical impact of sex hormones and hormone replacement therapy, improving ...

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Retrospective evaluation of school-related measures on pre-vaccination transmission dynamics of SARS-CoV-2 - Communications Medicine

Canfora, Escosio, et al. use an age-stratified transmission model fitted to Portuguese COVID-19 hospitalization and seroprevalence data to assess the impact of school closures before mass vaccination....

nature.com

Understanding, preventing, diagnosing and treating cardiometabolic disease

This cross-journal Collection calls for papers that advance mechanistic and clinical understanding of cardiometabolic disease.

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Effects of Psychedelics on the Brain

In this Collection, we welcome papers investigating how psychedelic compounds affect the brain across multiple levels of organization: from molecular and ...

nature.com

Advances in neurodevelopmental disorders

Editors welcome original research Articles, Reviews, and Perspectives that advance our understanding of the mechanisms underlying the onset and progression of ...

go.sn.pub

Advances in Pediatric Cancer Biology, Treatment and Outcomes

This cross-journal collection invites manuscripts that highlight advances across the pediatric cancer spectrum, from disease mechanism to clinical application ...

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Understanding, preventing, diagnosing and treating cardiometabolic disease

This cross-journal Collection calls for papers that advance mechanistic and clinical understanding of cardiometabolic disease.

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Prenatal and postnatal droughts interact in shaping cognitive development - Communications Medicine

Pradella et al. study the long-term cognitive impacts of drought exposure during pregnancy and the first years of life using data on two million 11–16-year-olds in rural India. While early-life droughts are associated with worse test performance, prenatal drought exposure mitigates the negative effects of postnatal drought.

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Advancing EEG-based assessment of consciousness and cognition in prolonged disorders of consciousness - Communications Medicine

Du Bois et al. use a structured, multiphase brain–computer interface to test how people with severe brain injuries can modulate brain activity through imagined movements. The results show that decoding these signals provides objective evidence of awareness and diagnostic information beyond traditional behavioural assessments.

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Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth - Communications Medicine

Nesbeth et al. use metabolome-wide association studies to identify newborn metabolic profiles associated with prenatal tobacco exposure and early birth. Results reveal changes in biopterin metabolism as a potential link between prenatal tobacco exposure and early birth.

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Deep learning using electroencephalogram (EEG) data for diagnosing and predicting SSRI response in major depressive disorder - Communications Medicine

Olbrich et al. apply deep-learning methods to EEG recordings to detect major depression and predict who will respond to SSRI treatment. They show that the models reach meaningful accuracy and identify key brain activity patterns, supporting the use of EEG-based tools for individualized treatment decisions.

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Sociodemographic disparities in Hepatitis C care utilization and testing in the United States - Communications Medicine

Ying et al analyze two national survey databases to identify trends and disparities in HCV screening and care. Results reveal overall low rates of screening and disproportionate emergency room use among rural, racial/ethnic minorities, Medicaid insured, and patients with substance use disorder

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Bacillus spore probiotics for alleviating functional constipation in children: a randomized, double-blind, placebo-controlled trial - Communications Medicine

Nguyen et al. conduct a randomized, double-blind, controlled clinical trial evaluating multi-strain Bacillus spore probiotics for treating functional constipation in preschool children. The probiotics significantly reduce constipation, anorexia, and underweight risk and improve immune markers and gut microbiota composition after 7–28 days of use.

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Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer - Communications Medicine

Van Keer et al. explore an entirely molecular cervical screening approach based on HPV and DNA methylation analysis in at-home collected urine from 454 women. The ASCL1/LHX8 methylation test detects nearly all cancers and a majority of CIN3, supporting the potential of full molecular screening in urine by primary HPV testing and methylation triage.

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Prenatal famine exposure restricts genetic effects on birth weight with implications for metabolic disease risk - Communications Medicine

Taeubert et al. examine the interaction between the prenatal environment, genetic predisposition to birth weight, and adult metabolic risk factors in the context of the Dutch Famine. Famine exposure later in pregnancy restricts genetic influences on birth weight and this effect is linked to higher glucose levels and adiposity in adulthood.

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hERG epitope mimic-decoy peptide corrects autoimmune-long QT syndrome in guinea pigs - Communications Medicine

Cupelli et al. explore a decoy peptide approach to correcting autoimmune-acquired long QT using a guinea pig model. Their study finds that decoy peptide-treated animals exhibit rescued cardiac repolarization parameters, suggesting therapeutic implications for precision modulation of ion channel function.

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Multilevel metabolic adaptation to exercise training - Communications Medicine

Knaan et al. examine metabolic and behavioral adaptations to a 12-week supervised aerobic exercise program in adults with overweight. Exercise induces energy compensation through reduced resting metabolism, improved movement efficiency, and selective shrinkage of highly metabolic organs, thereby limiting weight loss.

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Best cochlear locations for delivering interaural timing cues in electric hearing - Communications Medicine

Borjigin et al. test a personalized cochlear implant strategy that delivers low-rate timing cues to each user’s most sensitive cochlear location. This approach improves perception of interaural time differences for simple sounds such as tone stimuli, but restoring robust timing sensitivity for speech may require multiple sites.

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Multilevel predictors of ultra-processed food intake in Canadian preschoolers - Communications Medicine

Mousavi, Chen, Miliku et al. analyse dietary, family, and neighbourhood data from Canadian preschoolers to identify predictors of ultra-processed food intake. They find that higher intake is linked to parental diets, shorter breastfeeding, screen time, having older siblings, and poorer access to jobs and fresh food markets, among other factors.

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Lung Cancer

This Collection aims to elevate our collective understanding of lung cancer and ultimately improve survival rates and quality of life for those affected by ...

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Inflammation, Immunometabolism, and Chronic Disease

This cross-journal Collection focuses on studies that provide mechanistic insight with clear medical relevance into how inflammatory and immunometabolic ...

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Optimising patient centred drug development to realise impact - Communications Medicine

Calvert et al. highlight how patient-reported outcomes (PROs) provide critical evidence for drug regulation, reimbursement, and clinical care. They advocate for using international guidelines and tools to enhance data quality and maximize the impact of these data to support decision-making and patient-centred care.

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Optimising patient centred drug development to realise impact - Communications Medicine

Calvert et al. highlight how patient-reported outcomes (PROs) provide critical evidence for drug regulation, reimbursement, and clinical care. They advocate for using international guidelines and tools to enhance data quality and maximize the impact of these data to support decision-making and patient-centred care.

dlvr.it