Excited to share what I've been up to in @jennyoung.bsky.social lab! Bringing #Mechanobiology & #SpatialBiology together, we ask: How does local tissue stiffness relate to the molecular state of that same region? Spatial Mechanomics preprint here! 👇 @nusingapore.bsky.social @mbisg.bsky.social

Jennifer Young@jennyoung.bsky.social · 7d ago

Excited to share our lab's new preprint led by @huanting-ong.bsky.social on paired-surface spatial mechanomics! We link nanoindentation maps with #SpatialTranscriptomics to connect local tissue mechanics with molecular state. 🔗https://www.biorxiv.org/content/10.64898/2026.08.29.748050v1 🧵1/7

Check out this new preprint by @jennyoung.bsky.social and @huanting-ong.bsky.social on spatial mechanomics - linking mechanobiology and spatial transcriptomics! Available to read on @biorxivpreprint.bsky.social now.

Jennifer Young@jennyoung.bsky.social · 7d ago

Excited to share our lab's new preprint led by @huanting-ong.bsky.social on paired-surface spatial mechanomics! We link nanoindentation maps with #SpatialTranscriptomics to connect local tissue mechanics with molecular state. 🔗https://www.biorxiv.org/content/10.64898/2026.08.29.748050v1 🧵1/7

Honored to have been awarded the Yamaguchi Medal at the 10th World Congress of Biomechanics in Vancouver. Deeply grateful to APAB, my lab members, mentors, and collaborators! Privileged to present our lab’s recent work and connect with colleagues. #WCB2026 #APAB @mbisg.bsky.social, Physiology, NUS

Your cells may be thriving but your abstract still needs submitting 🧬😬 Deadline: June 9 #CellBio2026 #ASCB www.ascb.org/cellbio2026/

📢 Institut Jacques Monod Seminar 📅 June 4th 📍 Institut Jacques Monod Next week, Prof. Chwee Teck Lim ( @mbisg.bsky.social ) will present the Institut Jacques Monod seminar "How Geometry Drives Collective Cell Migration" ➡️ buff.ly/tj3l5hb

Experienced in nano-and micro-fabrication? MBI is recruiting a new Head of our Microfabrication Core Facility. More details in the flyer and at www.mbi.nus.edu.sg/jobs/seeking...

Wishing everyone a bright and happy Deepavali!

How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social

Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc

Tissue folding is a fundamental process occurring in animal organ development. Here, we study the progression of fold shape and the underlying mechanics in the development of the Drosophila wing disc....

doi.org

Delighted to host Anne Beghin (@mbisg.bsky.social) ✈️ and @merlinlange.bsky.social (Institut de la Vision and @czbiohub.bsky.social ) 🐟 for the Module 4 Multiscale analysis of 3D biological samples Good science and great people. #MiFoBio2025 is really a grand cru 🍷 @gdrimabio.bsky.social

I'm hiring a postdoc! If you're interested in researching mechanisms of 3D tissue morphogenesis and have experience studying cell dynamics and performing quantitative image analysis, consider joining us @mbisg.bsky.social! www.mbi.nus.edu.sg/jobs/seeking...

Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology. Apply here: dresdencondensates.org/join-us/ 🗓Deadline: 24. October

#Mifobio2025 Focus on the module 4 : 👉 Multi-scale imaging of biological systems We are delighted to welcome Anne BEGHIN @mbisg.bsky.social Lecture - “Breaking scale: Image Analysis–Based AI to Streamline multilevels 3D quantitative Imaging and Tackle the vEM Challenge” #GDRimabio

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy. mikeinmemoriam.sciencesconf.org

Have you ever wondered how microtubules withstand and respond to mechanical stress in cells? Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.

bioRxivpreprint@biorxivpreprint.bsky.social · 12mo ago

MAP65-1/PRC1 reinforces microtubules through nucleation https://www.biorxiv.org/content/10.1101/2025.09.14.676082v1

We would like to once again, thank all the sponsors for their generosity in supporting #MBIMPG2025 @leicamicrosystems.bsky.social @nikoninst.bsky.social @oxfordinstruments.bsky.social, Optics11Life, BGI, Office of Naval Research Global and Paeonia Foundation.

That closes out #MBIMPG2025! It would not have been possible without the efforts of the Scientific Organizing Committee, and special thanks to the admin team, A/V support, and student volunteers for ensuring a smooth conference 👏

Congratulations to our three poster prize winners for #MBIMPG2025! 🏆Rituraj Marwaha; Das Lab 🏆Boon Heng Ng; Chan Lab 🏆Marie Cutiongco ; @wtzhaolab.bsky.social Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!

Remarkable intravital two-photon imaging videos from @hirashima0203.bsky.social @mbisg.bsky.social visualising sperm movement through the epididymal duct, revealing how epithelial contractions promote active turbulence of sperm collectives, essential for sperm to acquire motility. #MBIMPG2025

Zhao Wenting @wtzhaolab.bsky.social shared two complementary studies highlighting how immune cells use curvature-sensitive mechanisms to leverage on nanoscale membrane deformations- both intrinsic and extrinsic—regulating signaling and motility. #MBIMPG2025

Kim Whye Leong @mbisg.bsky.social examined lumen development in ovarian follicles, a key step for ovulation transitions from a fluid network into a phase-separated state, regulated by cell-fluid surface tension—these dynamics may help nutrient exchange. #MBIMPG2025

Daniel Stedman @jtimaging.bsky.social presented a method using widefield fluorescence lifetime imaging microscopy to measure molecular tension changes at cell-cell interfaces within the beating zebrafish heart—both across a heartbeat and across developmental time. #MBIMPG2025

Returning to multi-dimensional models, Amit Pathak @washuengineers.bsky.social detailed how cell mechanical memory is retained from stiff 2D to fibrous 3D collagen matrices—even in hypoxic environments—to better understand tumor invasion in evolving microenvironments. #MBIMPG2025

Mineko Kengaku from Kyoto University continues the theme by sharing how Piezo-1 switches on a force generation mechanism in neuron migration and how DNA damage due to mechanostress in these narrow interstitial spaces is repaired by enhanced expression of topolsomerase IIb. #MBIMPG2025

Next, Tamal Das @tifr.res.in revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025

Decoding the programming of biological shapes, @carldmodes.bsky.social @math-mpicbg.bsky.social models epithelial cell sheets as an active solid—studying in-plane collective cell behaviour in Drosophila development, moving up in complexity from the 1D cephalic furrow to 3D wing disc. #MBIMPG2025

After an energizing morning, look forward to our final session of #MBIMPG2025! Session 7 will cover the mechanics of developmental biology, from collective cell migration to differentiation, across time and space!

Just one more day of #MBIMPG2025 left! But plenty to look forward to—one last Session of scientific talks, and two social excursions to the jungles! An exotic morning rainforest jungle walk and evening drinks at the concrete jungle roof-top bars @ Marina Bay! 🏞️🍹 See you there!

Ivan Yow @mbisg.bsky.social @schmidtsciences.bsky.social investigated the mechanics of 3D spheroid formation. Fyn initiates spheroid formation via the RhoA-ROCK pathway, leading to increased tissue viscosity and tension - and may initiate cardiomyocyte transdifferentiation! #MBIMPG2025

Back to compressive stress with Frank van Drogen. Combining a phospho-proteomic approach with RNAi-based validation, he looked at the ERK5 pathway in mammary gland cells, showing how it reduces tension promoting the migratory response to compression. #MBIMPG2025

Great talk from Elizabeth Chen @echenlab.bsky.social on how cell-cell fusion is a conserved, asymmetric process - where one cell invades the other through invasive, mechanically stiff actin protrusions (bundled by dynamin & WIP!), to form a fusogenic synapse. #MBIMPG2025