tomorrow!

Cant wait for the first tests 🚀

Frank Noe@franknoe.bsky.social · 2y ago

The BioEmu-1 model and inference code are now public under MIT license!!! Please go ahead, play with it and let us know if there are issues. github.com/microsoft/bi...

This is awesome! Great work! 🔥

Michael Jendrusch@mjendrusch.bsky.social · 2y ago

New protein ML preprint from my PhD project. We describe salad (sparse all-atom denoising), a family of efficient protein structure diffusion models and show that it works well on a bunch of protein design task previously described in the literature. Preprint: www.biorxiv.org/content/10.1... (1/N)

This www.biorxiv.org/content/10.1... Is so, so, so damn important work! 🔥 The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations. Time that we start "designing the un-Designable" 😆

Crosspost from X: After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton.org @hendrikdietz.bsky.social www.biorxiv.org/content/10.1...

Alphafold2 refinement improves designability of large de novo proteins

Recent advances in computational protein design have enabled the creation of novel proteins for a variety of purposes. The capability for producing custom-shape high-quality backbones for very large p...

biorxiv.org

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!