Alex Cagan

@atjcagan.bsky.social

Researching somatic evolution at the University of Cambridge and Wellcome Sanger Institute. Also a scientific illustrator.

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

rdcu.be

Delighted to have contributed a comment piece and the cover illustration to a @natecoevo.nature.com focus issue on "Evolution in medicine". I discuss how the emerging field of somatic evolution is providing new opportunities to understand disease and promote healthy ageing doi.org/10.1038/s415...

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Nature Ecology & Evolution@natecoevo.nature.com · 5mo ago

Our March issue is a Focus on "Evolution in medicine", out now! www.nature.com/natecolevol/... Including research & opinion on: ➡️Somatic evolution and health ➡️Predicting intrahost evolution ➡️Collateral sensitivity during antibiotic therapy Cover illustration by Alex Cagan @atjcagan.bsky.social

Cover of the March 2026 issue of Nature Ecology & Evolution. The image is inspired by Da Vinci's Vitruvian Man and depicts clonal evolution within our bodies and pathogens that affect our health via different sized circles within the man and images of microbes around the edges. There is a phylogenetic tree representing evolutionary approaches to medicine.

This is a fantastic opportunity to do exciting research on comparative somatic evolutionary genomics as part of a great team. I've collaborated with Peter for many years and highly recommend this position! Please email Peter if you'd like to learn more, including a copy of your CV.

Peter Sudmant@psudmant.bsky.social · 12mo ago

The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052

Thanks @amyboddy.bsky.social for the invitation to run this workshop on where ideas come from in science, barriers to creativity and how to overcome them. Great discussion from the group! I'm a convert to 'night science' @urialonlab.bsky.social

Amy Boddy@amyboddy.bsky.social · last yr.

Late night session on how to think of good ideas!! #EBECancer25 @atjcagan.bsky.social discusses the creativity in science & helped us practice different ways to think and talk about our science.

A new review paper for those interested in how comparative approaches are informing cancer research. Advances in genomic resources for non-traditional model organisms (whales, bats, and beyond!) is set to transform our ability to gain insights from cancer resistant species. doi.org/10.1038/s415...

Advancing cancer research via comparative oncology - Nature Reviews Cancer

Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...

doi.org