Cells may work with “Lego®️ bricks” 🧱 at the molecular level. Our new study shows that peroxiredoxins can mix different subunits to form hybrid complexes arranged in donut-like rings 🍩, creating molecular diversity that helps cells fine-tune stress and redox signaling responses. Out in Nat Chem Biol.

Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈 HyPerFLEX tracks cellular stress in real time, glows in multiple colours, works in low-oxygen environments, and could revolutionise research on aging, inflammation & disease!

4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.

Our first post on Bluesky! 1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins. www.biorxiv.org/content/10.1... Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins

Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...

biorxiv.org