Excited our ratiometric transcriptional activation (RTA) work led by postdoc Dr. Melissa Gray is out online today in Cell @cp-cell.bsky.social! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals in live cells.

Ratiometric transcriptional activation by protein degradation

By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to p...

cell.com

Excited to share our work on a new way to sense protein abundance changes. Protein loss has been a defining phenotype for biological, and more recently, small molecule discovery, and we wondered what we could discover w/ greater scale+sensitivity.

bioRxiv Synthetic Biology@biorxiv-synthbio.bsky.social · 5mo ago

Ratiometric transcriptional activation by protein degradation https://www.biorxiv.org/content/10.64898/2026.05.16.725679v1

Excited to share our latest preprint on work led by postdoc Robert Lusi (@rflusi.bsky.social)! Introducing ALTER (AGO-Led Targeted Editing of RNA) for non-downregulatory RNA manipulation by repurposing hAGO2, non-immunogenic and capitalizing on evolution. www.biorxiv.org/content/10.6...

Really cool approach to an impactful problem from @greenahn.bsky.social @uwproteindesign.bsky.social!

Green Ahn@greenahn.bsky.social · last yr.

pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.110…, we developed computational methods to rationally design pH-sensitive binders. 🧵

Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.

Incredibly proud of @christineisadora.bsky.social for defending her PhD work today! The first PhD from the Banik lab, and an amazing story on targeted protein relocalization and TRAMs! Her PhD work spans small molecules, neurobiology, cell engineering, and computational method development.

If you want to understand how cells function, you have to work out what proteins interact with — and where https://go.nature.com/4hYLaol

Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives

Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.

go.nature.com

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime www.nature.com/articles/s41...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods

Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

nature.com

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

Amazing to see the LYTAC technology get to this point, catalytic extracellular degraders could open many new therapeutic opportunities or perhaps even become standard of care compared to antagonistic antibodies alone. Congrats to Lycia Tx!

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 2y ago

The unique pharmacology of targeted degraders (eg PROTACs) leverages their sub-stoichiometric “catalytic” activity. Now ⁦‪Lycia Tx‬⁩ reports catalytic (cata)LYTACs for potent, durable extracellular #TPD, cleared IgE in NHPs, superior to omalizumab 👏 www.biorxiv.org/content/10.1...