The reactivation content was way more specific to the experience in controls. Overall, our data shows that both reactivations and consolidation relies on intact PV+ activity locally in the cortex.

Next we looked at the activity in post-training rest. Reactivations in controls were biased to the rewarded cue and persisted for hours, but with hM4Di activation the reactivations barely happened, despite higher overall activity in the population

We used RiboL1 jGCaMP8 to image large populations of neurons during training and rest. Controls developed a bias to the rewarded cue while the responses in hM4Di mice remained exactly like the naive state

Using this setup we show that post-training reduction of PV+ activity completely prevented learning. On off-days with saline injections the mice improved, but reverted to chance levels after a single hM4Di activation

Are cue-specific reactivations in the cortex necessary for consolidation and learning? To address this we targeted neural activity in POR after daily training in a Go/NoGo task

New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...

Local inhibitory circuits mediate cortical reactivations and memory consolidation

Reducing inhibitory activity after training prevents cortical reactivations and memory consolidation.

science.org