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While over 50% of U.S. children test positive for common allergens, only ~7% of Amish children do. Asthma rates run just 1–2% in Amish Children vs. ~8–10% in non-Amish kids. Their secret? See this Washington Post article that cites research from JACI. wapo.st/4odEBmq

Allergies seem nearly impossible to avoid — unless you’re Amish

One Amish community living in northern Indiana is considered one of the least allergic populations ever measured in the developed world.

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Clinical trials of therapies for asthma and food allergy are complex, and there is intense interest in the development of biomarkers to predict natural disease history and response to therapy. Read a summary of a US FDA-hosted workshop discussion. bit.ly/4juKdVD

Biomarker-driven drug development for allergic diseases and asthma: An FDA public workshop

The US Food and Drug Administration (FDA) hosted a workshop on February 22, 2024, to discuss the status of biomarkers in drug development for allergic…

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The use of administrative data, or data from research-independent repositories, offers a valuable tool for birth cohort studies. It also brings challenges. How have administrative data have enhanced asthma, allergy, and immune disorder birth cohorts? bit.ly/43M6fgK

Advancing birth cohort studies using administrative and other research-independent data repositories: Opportunities and challenges

The birth cohort study design is an essential epidemiologic tool for investigating the developmental origins of health and disease. Birth cohorts have…

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Data from a phase 2 trial of GR1802, a novel anti-IL-4Ra monoclonal antibody, for the treatment of patients with uncontrolled chronic rhinosinusitis with nasal polyps suggest that the treatment is well-tolerated and effective. Here’s more. bit.ly/44F8VPn

Efficacy and safety of GR1802 in uncontrolled chronic rhinosinusitis with nasal polyps: Placebo-controlled phase 2 trial

Anti–IL-4 receptor subunit alpha (IL-4Rα) treatments can effectively treat eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). However, t…

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