Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...

Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays - Molecular Systems Biology

Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...

link.springer.com

Thanks to the Dutch Cancer Society (KWF) 6 new research projects can get started. Four of the 6 projects are supported through proceeds from Alpe d'HuZes. From mechanisms of PARP inhibitor resistance and telomere instability to immunosuppression, stress and immunotherapy response and more:

🎉Congratulations to Fraser Johnson on receiving an NWO Veni grant! Fraser will develop new tools to identify tumor-reactive T cells in melanoma, helping to reveal why some anti-tumor immune responses succeed while others fail.

We are grateful to KWF Dutch Cancer Society for awarding €1.37M to Remond Fijneman and his team for the DIDACTIC study. By combining ctDNA with tumor characteristics, they will investigate whether chemotherapy can be safely omitted for low-risk stage III colon cancer. #PrecisionOncology

Have you previously worked at the NKI? Join our LinkedIn alumni group. A place to reconnect with former colleagues, expand your professional network and stay involved with the NKI community: linkedin.com/groups/1842007/ Feel free to share this post with former NKI colleagues!

"Like pollen carried by bees" - so true. Thanks @eu-life.bsky.social for making this valuable exchange happen.

EU-LIFE@eu-life.bsky.social · 2mo ago

🐝 Some collaborations grow over years before they meet face to face. In a new #EULIFEblog post, Hongchang Fu, postdoc at @crick.ac.uk , reflects on how his visit to @nkinl.bsky.social helped continue a long-standing collaboration and showed why in-person academic exchanges matter ➡️ bit.ly/3R6N0ML

Will you be our next junior group leader? Check out how Natalie Scholes, Gordie Watt and @woutoosterheert.bsky.social experience starting their groups at the Netherlands Cancer Institute. Apply before August: www.nki.nl/news-events/... #Vacancy #JuniorPI #ResearchOpportunity #NKI #EarlyDetection

🏅Congratulations to René Bernards, who has received China’s highest award for foreign experts in science and technology cooperation. A wonderful recognition of a long-standing international collaboration to move cancer research forward.

On Be Open About Animal Research Day researchers from leading Dutch research institutes are speaking out in support of openness about animal research. They explain why a combination of this research and animal-free methods remains necessary. www.stichtinginformatiedierproeven.nl/researchers-...

In June, several NKI PhD candidates defended their theses, covering gene regulation, immunotherapy, shared decision-making and support for young adults with cancer. Congratulations to Danielle, Chantal, Song and Milou. #CancerResearch #PhDDefense

New in The Lancet Oncology: the phase III SUBITO trial prospectively validates HRD-targeted treatment in stage III HER2-negative breast cancer. Comparable survival, substantially lower toxicity, and no added benefit from intensified chemotherapy. 🔗 doi.org/10.1016/S147...

How does BRCA1-related breast cancer begin? With support from the Gray Foundation, NKI teams led by Hendrik Messal and @josjonkers.bsky.social will study the earliest cellular, genetic and immune changes that allow abnormal cells to survive and expand #BRCA1 #BreastCancer #CancerResearch

We are looking for a Junior Group Leader in Early Cancer Detection: an innovative scientist ready to build an independent research group and bring new ideas to one of our key research themes. Apply: www.nki.nl/news-events/... #tenure #vacancy #juniorPI #faculty #NKI

🎉 Congratulations to Leila Akkari, who has been elected as an EMBO Member. A wonderful recognition of her research excellence, scientific leadership, and the inspired team behind her work on the tumor microenvironment in cancer. #EMBOMembers2026

Breakthroughs don’t happen by following the obvious path. They begin with people who dare to ask new questions. Who connect ideas others might not see. Who bring science, imagination and ambition together. At the NKI, these inspired minds move research forward. Where science meets inspired minds.

New in The Lancet Oncology: NKI researchers present ARTIMES, an AI model for pleural mesothelioma that measures full tumor volume on CT scans and outperforms physicians and RECIST criteria in treatment response assessment. 🔗 doi.org/10.1016/S147...

New PRECISION consortium research maps early DNA changes in DCIS, pointing to SHOREs and ecDNA as possible signs of more aggressive evolution. Read in Nature Communications: www.nature.com/articles/s41...

What happens when the EU-LIFE community comes together in one place? Last week in Amsterdam, we exchanged ideas, explored collaboration opportunities and aligned on key issues shaping European research. Thank you to @nkinl.bsky.social for the warm hospitality! Read more ➡️ bit.ly/4x9Xgnk

Couldn't agree more!

CeMM@cemm.oeaw.ac.at · 3mo ago

What a great #EULIFE2026 Community Meeting at @nkinl.bsky.social this week! 👏 Big thanks to the @eu-life.bsky.social office, NKI, fellow directors & WG members for 3 inspiring days of collaboration, knowledge exchange & key discussions on the future of European life sciences research! 🔬🇪🇺

📍 The #EULIFE2026 Community Meeting is underway in Amsterdam! Hosted by @nkinl.bsky.social, we kicked off with welcomes from Thijn Brummelkamp and updates from EU-LIFE Chair Marta Miączyńska & Executive Director Marta Agostinho. Looking forward to inspiring exchanges!

We’re proud to join #EWAC2026 — a week of action against cancer across Europe. At #CCE, we advance prevention & early detection through collaboration, innovation, and data-driven precision prevention. @gustaveroussy.fr @vhio.bsky.social @nkinl.bsky.social @nct-heidelberg.bsky.social

I’m hiring a Research Technician and a Computational Postdoc! 💻 Computational Postdoc to model context-dependent protein interactions: open until 15th of June: www.werkenbijavl.nl/vacatures/co... 🔬 Technician: open until 3rd of June: www.werkenbijavl.nl/vacatures/re... Please share! #ScienceJobs

Computational Postdoc | Werken bij AVL

Computational postdoc in the Lindeboom lab to study context-dependent protein interactions The Lindeboom lab is looking for a talented and motivated ERC-funded computational postdoc who is interested...

werkenbijavl.nl

Powerful tools are uncovering the “control knobs” of the genome; accelerating how we identify regulatory DNA and even opening the door to rewriting gene expression. Great to see this momentum in the field, including the work of @basvansteensellab.bsky.social 🔗 www.nature.com/articles/d41...

These powerful tools reveal the ‘control knobs’ of the genome

By accelerating the identification of DNA sequences that control gene expression, assays are revealing the hidden grammar of the regulatory genome — and giving scientists the means to rewrite it.

nature.com

Congratulations to all scientists who were selected for a synergy grant by @oncodeinstitute.bsky.social! Scientific collaboration is more important than ever, so we are looking forward to seeing our talented researchers start their new collaborations.

🎉 Congratulations to Michiel Vermeulen @michielvermeulen.bsky.social on his election to the Royal Netherlands Academy of Arts and Sciences @knaw-nl.bsky.social His pioneering work on epigenetic regulation is advancing our understanding of cancer and informing new therapeutic strategies.

🎓 Thanks to new treatments like immunotherapy, patients have better outcomes and live longer. That, argues PhD candidate Mees Egeler, makes it even more important to focus on their quality of life.

🎧 New podcast out!! Daniel Peeper talks functional oncogenomics and cancer research on The Immunology Podcast. Listen here ➡️ www.immunologypodcast.com/ep-126-funct... #CancerResearch #Oncogenomics

Ep. 126: “Functional Oncogenomics” Featuring Dr. Daniel Peeper - The I…

Dr. Daniel Peeper is a Professor in Functional Oncogenomics at VU University Amsterdam, heading the Department of Molecular Oncology & Immunology and chairing the Research Fac…

immunologypodcast.com

Congratulations to Rik Lindeboom on receiving the 2026 NVBMB Prize 🎉 The jury unanimously recognized Rik as a rising star in biochemistry & molecular biology, praising seminal contributions, bold high-impact research, exceptional productivity, and a strong commitment to open tools for the community

Our researchers are exploring whether radiotherapy for soft tissue sarcoma can be delivered in a shorter, less burdensome way without compromising outcomes. The SCOPES studies mark an exciting step forward in rethinking long‑standing treatment standards. Read more ➡️ www.nki.nl/news-events/...

🌷 Junior PI Hendrik Messal: "Stepping into a group leader role at the NKI has been both busy and gratifying, in a place where disciplines, technologies, and people converge with a shared sense of purpose. [...]" Want to join Hendrik and others as a junoir PI? Apply now: www.nki.nl/news-events/...