We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack

Proud to see this preprint from @virginiabusetto.bsky.social out today — she's uncovered how a pseudohelicase-centered complex couples RNA cleavage to poly(UG)ylation. Beautiful mechanistic work from the lab, go check out the thread! 🧵

Virginia Busetto@virginiabusetto.bsky.social · yesterday

Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6...

Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6...

Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair. A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌 doi.org/10.64898/202...

Looking forward to our next #globalimmuno talk this Wednesday, September 9, 2026, at 9am PST, noon EST, 4pm GMT by Dr. Coco Chu. Title: “Neuro- and stromal-immune interactions in the intestine” ZOOM LINK: us06web.zoom.us/webinar/regi... LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS

🤯 This is how much space an IDR can occupy. Often hard to picture until you see it. 🤔 Did you expect this? This is my favorite complex, Zincore. Using Cryo-EM, I could only resolve the folded core. Here, I modeled the IDRs with AlphaFold3 and visualized it in Blender using MolecularNodes.

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

Mitochondrial protein import couples proteostasis failure to mitochondrial permeabilization https://www.biorxiv.org/content/10.64898/2026.09.03.749044v1

IMP postdoc Elias Adriaenssens has received an ERC Starting Grant worth close to €1.5 million. He will study how cells decide when to dispose of their organelles—and how they prevent healthy ones from being destroyed: https://bit.ly/4zUBQMy

The ULK1 complex triggers autophagy on membranes, but with no typical membrane binding domains, how does it get there? See the answer in a brilliant collective effort out now in Science Advances: www.science.org/doi/10.1126/....

AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳

Why do leukemia patients stop responding to venetoclax, a precision drug that blocks cancer cells' ability to escape cell death? 🩸 Our new study in Advanced Science reveals resistance isn't one-size-fits-all 🧵 📝 Learn more: www.biophys.mpg.de/2925331/rese...

Same single cell, two modalities—both at depth. We digest protein first, run Smart-seq3xpress + C18 (Evotip) separation: peptides captured, cDNA in flowthrough. In HeLa & stem cells, proteome tracks cell state; RNA variance flags transitioning cells. www.biorxiv.org/content/10.6...

In the same cell, the proteome defines cellular state and the transcriptome marks transitions

Bulk transcriptome and proteome correlate only modestly, but this has not been investigated in the same cell or across cell-state changes. Here we introduce a scalable technology that quantifies thous...

biorxiv.org

Review @cp-immunity.bsky.social Canonical and noncanonical autophagy in immunity www.cell.com/immunity/ful...

0/ New preprint from the Stark and Grün labs! @reyna-rosales.bsky.social @dominicgrun.bsky.social @alex-stark.bsky.social We developed BARe-seq to ask what in the DNA controls transcriptional bursting - key findings for anyone working on transcription, gene regulation, or cis-regulatory elements 🧵

We are excited to share our new @biorxivpreprint.bsky.social examining the structural basis for receptor binding by two flaviviruses 🤩: www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social

Very pleased to share this new study: In a truly collaborative effort with the lab of Pim Huis in 't Veld @huis.bsky.social, we combined biochemistry with cell biological and genomic approaches to uncover how CIP2A works in mitotic DNA repair. www.biorxiv.org/content/10.6...

CIP2A tetramerization is required for mitotic DNA repair

DNA lesions that persist in mitosis threaten genome stability. These lesions recruit TOPBP1-CIP2A, a complex crucial to tether and process damaged DNA on mitotic chromosomes. Importantly, CIP2A is syn...

biorxiv.org

Kinetic Control of Nuclear-encoded Mitochondrial mRNA Localization and Local Translation https://www.biorxiv.org/content/10.64898/2026.08.22.746448v1

We've arrived on Bluesky! We hope you will follow along as we share inspiring, motivational and exciting content about the achievements and individuals that have been awarded a Nobel Prize. Stay tuned.

MOLECULAR BASIS FOR PINK1 MATURATION https://www.biorxiv.org/content/10.64898/2026.08.19.745883v1

Proteolytic control of mitochondrial calcium transport by intermembrane-space proteases www.biorxiv.org/content/10.6...

Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...

Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n

Chromatin is dispensable for bacterial life

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

biorxiv.org

Triplet tumbling microscopy enables in situ quantification of protein complex assembly and dynamics: www.biorxiv.org/content/10.6...

Triplet tumbling microscopy enables in situ quantification of protein complex assembly and dynamics

Protein-protein interactions (PPIs) mediate diverse cellular processes, but PPIs are typically characterized using reconstituted in vitro biochemical and biophysical approaches. Current approaches for...

biorxiv.org

🌱 We are hiring! I’m looking for a postdoctoral researcher to join the Julian Lab at BOKU University Vienna as part of our FWF ASTRA-funded VITAL project. 🔬 Plant cell biology & vacuolar remodeling 📅 2 years, starting early 2027 ⏳ Apply by 30 September

If you are looking for a Postdoc with a fantastic PI on a very cool project, studying vacuolar quality control, don‘t hesitate to apply!

Jose Julian@josejulian.bsky.social · 3w ago

🌱 We are hiring! I’m looking for a postdoctoral researcher to join the Julian Lab at BOKU University Vienna as part of our FWF ASTRA-funded VITAL project. 🔬 Plant cell biology & vacuolar remodeling 📅 2 years, starting early 2027 ⏳ Apply by 30 September

A negative regulator of mitochondrial complex I assembly adapts respiration to cellular energy demand

A negative regulator of mitochondrial complex I assembly adapts respiration to cellular energy demand

Li et al. identify TMEM141 as a negative regulator of mitochondrial complex I assembly. Under high energy demand, the YME1L1 and AFG3L2 proteases degrade TMEM141, relieving its inhibition of the assembly factor TIMMDC1. This work reveals a mechanism that adapts complex I assembly to OXPHOS demands.

dlvr.it

The effectiveness of progranulin gene therapy in FTD models is improved by blocking the protein’s carboxyl terminus, which prevents sortilin binding www.science.org/doi/10.1126/...

A stress response can be a great starting point for discovering new biology! By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis. Here’s the first one we characterized: www.pnas.org/doi/10.1073/...

VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS

Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...

pnas.org

Perturb-ME: Scalable mechanism discovery from phenotype-enriched genome-wide screens https://www.biorxiv.org/content/10.64898/2026.08.17.745330v1