Ebola kills 3,000 in DR Congo as control efforts aren’t measuring up

cidrap.umn.edu

Widespread SARS-CoV-2 infection in free-ranging Neotropical bats suggests repeated human-to-bat spillback

Bats harbor exceptional coronavirus diversity and are considered ancestral sources of several human pathogens. As SARS-CoV-2 transitioned from pandemic emergence to global endemicity in humans, concer...

biorxiv.org

Atg23 prevents aberrant fusion of Atg9 vesicles during delivery to autophagosome formation sites - The EMBO Journal

Autophagosome biogenesis depends on the accurate delivery of membrane lipids to the pre-autophagosomal structure. Golgi/endosome-derived Atg9 vesicles provide the membrane seed for this process, but h...

link.springer.com

Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection

In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.

science.org

Rotavirus vaccine shows strong global results in preschoolers

The vaccine has been available since 2006 and is 76% protective against deaths caused by rotavirus-related acute gastroenteritis.

cidrap.umn.edu

Potential threats of porcine Getah virus outbreaks and its specific antagonism of host antiviral response through proteasome-dependent degradation of P46 by nsP2

Author summary Alphaviruses pose a constant threat to public health, and despite their potential for global emergence, there are currently no approved therapies or vaccines available against most of these viruses. In the past few years (2022–2025), the porcine Getah virus (GETV), a member of genus Alphavirus, has re-emerged in many parts of the world, triggering diarrhea-related disease outbreaks of varying scales within the pig industry. Understanding the pathogenesis of alphaviruses is essential for the developments of effective antiviral therapeutics. This study reports the successful isolation and characterization of a virulent GETV strain, JLY1, from diarrheic piglets in China. Then, we identified P46 as an antiviral host factor against GETV. Interestingly, unlike CHIKV, VEEV, SINV, SFV and RRV, GETV antagonizes P46 through a unique pathway involving Lys48-linked proteasome-dependent degradation. The present study describes a novel role of the GETV nonstructural protein 2 in targeting P46 to counteract host’s antiviral response, and reveals the mechanism by which GETV can antagonize against P46.

journals.plos.org

Equine influenza virus at 70: What horses taught us about flu

journals.plos.org

SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death - Communications Biology

SARS-CoV-2 ORF3a variations from the Delta variant differentiate it from other variants of concern; these mutations promote lysosome damage and multimodal cell death activation associated with disease...

nature.com

nature.com

Natural immune escape mutations in the envelope proteins of hepatitis B virus (HBV) regulate the assembly and infectivity of human hepatitis delta virus (HDV) | Journal of Virology

The study demonstrated that anti-hepatitis B virus (HBV) immune response via selection for the immune escape mutations (IEMs) in HBV envelope proteins (surface antigen, HBsAg) can considerably reduce the assembly and/or infectivity of hepatitis delta virus (HDV) virions coated with HBsAg. The IEMs could down-regulate concomitant HDV infection mostly via affecting HDV infectivity, which was considerably inhibited by 13 out of 35 IEMs. The HDV spread/super-infection, which are expected to be suppressed by inhibited via HBV-specific IEMs the assembly and/or infectivity of HDV virions, should result in a reduced HDV reservoir in infected livers. The examination of the inhibition of HDV infectivity by IEMs apparently indicated that the major antigenic loop (MAL) of HBsAg could contain the residues primarily involved in viral attachment/entry and also the residues mostly regulating intracellular post-entry trafficking of HDV virions. The data advance our understanding of the MAL functioning during infection and of the indirect regulation of the HDV life cycle through the anti-HBV immune response.

journals.asm.org

C.D.C. Director Challenges Pennsylvania’s Report of Two Measles Deaths

Questioning a state’s investigation is highly unusual for the public health agency, but reflects tensions between the Trump administration and many states over health issues.

nytimes.com

Ebola death toll approaches 3,000, as case-fatality rate hovers around 50%

Total cases have passed 6,000 in DR Congo.

cidrap.umn.edu

Conflicting information continues in measles-associated death of Pennsylvania newborn

cidrap.umn.edu

nature.com

nature.com

Tracking viruses and building the science to understand them

Delia Doreen Djuicy is uncovering Cameroon’s hidden viral threats while building the country’s capacity to detect and investigate emerging diseases.

nature.com

nature.com

Pathogenesis and neurotropism of a contemporary Powassan virus lineage II strain in mice | Journal of Virology

Tick-borne flaviviruses exhibit considerable genetic and phenotypic diversity in nature, but it is unclear if this influences their transmission and pathogenesis. Defining the mechanisms of pathogenesis requires understanding how inter-lineage variation translates to phenotypic differences in viral dissemination and neuroinvasion. This study demonstrates that even closely related Powassan virus (POWV) lineage II strains display distinct disease phenotypes that are only partially attributable to nonsynonymous consensus mutations within the viral coding sequence. By highlighting the complexity of strain-dependent POWV pathogenesis and neurotropism in mice, these findings provide valuable insights into how POWV lineage II diversity may shape disease progression and severity in humans.

journals.asm.org

Early antivirals for kids with flu tied to dramatically lower risk of hospitalization

While antivirals remain highly effective at keeping children from the hospital, the authors say they do not replace annual flu vaccination.

cidrap.umn.edu

Ebola vaccination effort begins in DR Congo

cidrap.umn.edu

Measles cases continue to climb in Pennsylvania outbreak, as other states report new cases

cidrap.umn.edu

N-linked glycosylation sites with low occupancy support sustained circulation of the A(H3N2) influenza A virus in the human population | Journal of Virology

Many of the glycosylation sites on the hemagglutinin of influenza A viruses are near antigenic sites, such that the glycans block antibody recognition and help evade population immunity. However, glyc...

journals.asm.org

Mucosal IgA to pre-fusion F protein predicts protection from RSV infection in a high burden setting - Nature Communications

Hodgson et al present a longitudinal study of a Gambian community and report that antibodies in nasal fluid predict protection from Respiratory Syncytial Virus (RSV) infection better than those in blo...

nature.com

Insights into longevity and virus-driven adaptation from Myotis bat genomes - Nature

Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.

nature.com

Pericyte dysfunction alone may be insufficient to drive tick-borne orthoflavivirus non-structural protein 1-mediated microvascular permeability

The emerging tick-borne flaviviruses Alkhumra haemorrhagic fever virus (AHFV) and Kyasanur Forest disease virus (KFDV) can cause severe haemorrhagic disease, yet the mechanisms driving this vascular l...

go.shr.lc

What to Know About New Covid Vaccines for Fall 2026

The shots have been approved for people 65 and older, and for younger people with underlying conditions. Others may be able to get them off label.

nytimes.com

Ebola outbreak officially ends in Uganda as CEPI announces new vaccine candidate

cidrap.umn.edu