🚨It’s here! Our new preprint is live on bioRxiv🚨 A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵 www.biorxiv.org/content/10.1...

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

The tumor microenvironment (TME) of chronic inflammation-associated cancers (CIACs) is shaped by cycles of injury and maladaptive repair, yet the principles organizing fibrotic stroma in these tumors ...

biorxiv.org

🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form 🔗 Paper: www.nature.com/articles/s42... 📖 News & Views: www.nature.com/articles/s42... 💻 Code: corneto.org 🧵 Thread 👇

Had a blast writing this News & Views piece w/ ⁦‪@eldadtzahor.bsky.social on an interesting study uncovering a role for ARID5A in cardiac #aging, #inflammation & #fibrosis. ⁦‪@natcardiovascres.nature.com www.nature.com/articles/s44...

ARID5A promotes inflammation and fibrosis during cardiac aging - Nature Cardiovascular Research

A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis an...

nature.com

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.

Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

Nature Biotechnology@natbiotech.nature.com · last yr.

High-dimensional imaging using combinatorial channel multiplexing and deep learning go.nature.com/4hGPfO0

Theory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social

Shoval Miyara@shovalmiyara.bsky.social · last yr.

Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳 Cold and hot fibrosis define clinically distinct cardiac pathologies www.cell.com/cell-systems... Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉 @urialonlab.bsky.social @eldadtzahor.bsky.social

Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳 Cold and hot fibrosis define clinically distinct cardiac pathologies www.cell.com/cell-systems... Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉 @urialonlab.bsky.social @eldadtzahor.bsky.social

How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪 Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻 🧵 @cp-immunity.bsky.social www.cell.com/immunity/ful...

Cardiac scars can be classified as "hot" or "cold," each requiring distinct treatments. This discovery could lead to innovative therapies for heart disease and fibrosis in other organs. doi.org/g85hm2

Mending a broken heart: Two types of scars in injured cardiac tissue, two paths to healing

Not all scars are created equal. That's the conclusion of a new study by Weizmann Institute of Science researchers: They found that two distinct types of scars, referred to as "hot" and "cold," can form in the diseased heart, and that these two types call for entirely different treatments.

medicalxpress.com

Congrats to @shovalmiyara.bsky.social,Miri Adler, @eldadtzahor.bsky.social & @urialonlab.bsky.social on this great work! We're glad to have supported the translation of findings from theoretical and animal models to human myocardial infarction data using LIANA+ (liana-py.readthedocs.io)

Shoval Miyara@shovalmiyara.bsky.social · last yr.

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

Happy to share our new preprint: A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver: www.biorxiv.org/content/10.1...

Fantastic work of Shoval and the rest of the team on cardiac fibrosis. I hope the field will follow our categories of cold and hot fibrosis.

Shoval Miyara@shovalmiyara.bsky.social · last yr.

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

🩳 Two types of fibrosis, treatment decision aided by mathematical modeling! 🧬🖥️ 📄 The paper is open-access at @cellpress.bsky.social Systems 🔓 🔗 doi.org/10.1016/j.ce... 🧪 ▶️ Follow @AdlungLab.com for more systems biology news 🥜 5/5

🐁 Excitingly, inhibiting TIMP1—a key myofibroblast autocrine growth factor—with neutralizing antibodies reduced cold fibrosis in post-myocardial infarction mice. 🔦 This highlights a novel strategy to mitigate fibrotic remodeling in acute cardiac injuries. 4/5

🔄 @shovalmiyara.bsky.social et al. from @urialonlab.bsky.social reveal that cold fibrosis is maintained by an autocrine loop in myofibroblasts, offering a new therapeutic target. 🛜 In contrast, hot fibrosis involves persistent immune cell interactions. 3/5

💬 "Cold" fibrosis emerges from acute injuries like myocardial infarction, while "hot" fibrosis is driven by macrophage-myofibroblast crosstalk in chronic cardiac pathologies. 2/5

🥵🥶 "You're hot, and you're cold..." 🎶 💔 Did you know that this also applies to a broken heart (aka. cardiac fibrosis 🤓)? 🧵 1/5

Very happy to have contributed to this great work! “Hot” and “cold”fibrosis after heart attacks could be affected by targeting myofibroblast’s Timp1. Congratulations @shovalmiyara.bsky.social and @eldadtzahor.bsky.social

Shoval Miyara@shovalmiyara.bsky.social · last yr.

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

I heard about this interesting story a couple of years ago at an AHA meeting @ahascience.bsky.social. It's great to see it published @CellSystems. Congratulations @shovalmiyara.bsky.social‬, @eldadtzahor.bsky.social @urialonlab.bsky.social et al!

Shoval Miyara@shovalmiyara.bsky.social · last yr.

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

A grand project from the one and only @shovalmiyara.bsky.social, redefining what cardiac fibrosis is 🫀❤️‍🔥 It's been inspiring to see this story take shape Huge congrats!

Shoval Miyara@shovalmiyara.bsky.social · last yr.

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

Cold and hot fibrosis define clinically distinct cardiac pathologies

Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,” involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven “cold fibrosis,” contr...

cell.com

Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress? We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)

@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....