Undercover footage verified by Channel 4 News reveals a secret plot by senior Reform UK figures to break the law on party donations. A leading legal expert is now calling for a criminal investigation. 🔗 Read the exclusive story on Substack:

Exclusive: Nigel Farage filmed undercover celebrating secret new foreign donations

Undercover footage verified by Channel 4 News reveals a secret plot by senior Reform UK figures to break the law on party donations. A leading legal expert is now calling for a criminal investigation.

channel4news.substack.com

🚨 ‼️ NEW PUBLICATION ‼️ While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell. read the paper here: www.science.org/doi/10.1126/...

Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns

While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...

science.org

How do DNA duplexes recognize and pair with each other? Thomas Catley, Victor Velasco Berrelleza, @alicepyne.bsky.social and myself present the first direct visualization of DNA-DNA pairing mediated by divalent cations, confirming the decade-old DNA zipper model! doi.org/10.1093/nar/...

Two years ago @lassemiddendorf.bsky.social and I noticed that structure and disorder predictor are discordant for de novo emerged and randomized proteins. We now identified which sequences drive these discordant predictions and what properties they have. 1/6 www.biorxiv.org/content/10.6...

A discrete protein subset drives structure prediction discordance in orphan proteins

Structure and disorder predictors are increasingly used as decision-grade tools in protein engineering and in the analysis of newly emerged proteins, yet how the current state-of-the-art behaves on se...

biorxiv.org

🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: https://apply.interfolio.com/190640

Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n

Chromatin is dispensable for bacterial life

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

biorxiv.org

Professor in Bacteriophage Biology & Evolution at the University of British Columbia (UBC). Closing date 1 October, with an expected start date no earlier than January 1, 2027, and a salary within the range of $200,000 to $270,000 per year. For details: ubc.wd10.myworkdayjobs.com/en-US/ubcfac...

The GMI @gmivienna.bsky.social of the @oeaw.bsky.social seeks to appoint a Scientific Director (f/m/x) to lead one of Europe’s premier research institutes in plant biology. Apply by Nov. 15 via GMI.search.director@oeaw.ac.at. More information: www.oeaw.ac.at/de/gmi/join-...

🚨 Job alert! 🚨 Join the faculty at UW–Madison Bacteriology! We have two faculty searches: • Asst Prof (Microbial Communities & Bioeconomy) • Asst / Assoc / Full Prof (Systems & Synthetic Biology) Check out the open positions and apply👇 #FacultyJobs #SynBio #Microbiology #Astrobiology #Evolution

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · last mo.

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Bacteriocins in archaea and archaeocins in bacteria. @romainstrock.bsky.social surveys the the exchange of molecular weaponry between archaea and bacteria. www.biorxiv.org/content/10.6...

Bacteriocins in archaea and archaeocins in bacteria

Archaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...

biorxiv.org

New preprint: how are young and old proteins distributed in sequence space? 🌌 Comparing de novo, intergenic and canonical proteins from yeast and fly with length- and composition-matched randomized controls, using alignment-free k-mer distances. 1/7 doi.org/10.64898/202...

Interesting. Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab. www.cell.com/cell/abstrac...

A spliceosome-independent eukaryote generated by complete intron removal

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

cell.com

Well done, Chung!

Chung Hyun Cho@chc-evobio.bsky.social · 2mo ago

Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

I agree with this take, both in terms of the frankly needless binarizing framing and on the broader point of public metrics versus individual values. What is and is not important will be a matter for you to decide and will differ from person to person based on their priorities and values 1/n

Robert Insall@robinsall.bsky.social · 3mo ago

This, emphatically, shouldn't have been done, and shouldn't be used. You'd think we'd have learned that someone else's contextless algorithmic division of science outputs into "the best" and "not the best" is a disaster. Doesn't matter whether AI or Elsevier does it. the-one-percent.qedscience.com

Our biology department at Université Laval has a faculty position in Cell Biology, Molecular Biology, or Genetics. We have an Institute of Integrative and Systems biology, we are unionized, and Québec City is a wonderful mix of culture and access to nature. AMA universityaffairs.ca/search-jobs/...

Search Jobs - University Affairs

universityaffairs.ca

I'd like to have access to the conveyor belt of groundbreaking discoveries in the Nobu lab, please.

Masaru Nobu@masarunobu.bsky.social · 3mo ago

Parasitic bacteria feeding on their hosts’ RNA!? New cultures and Patescibacteriota/Minisyncoccota/CPR continue to surprise us… www.biorxiv.org/content/10.6...

Parasitic bacteria feeding on their hosts’ RNA!? New cultures and Patescibacteriota/Minisyncoccota/CPR continue to surprise us… www.biorxiv.org/content/10.6...

A representative of a ubiquitous bacterial lineage parasitically feeds on host RNA

Cellular metabolism is widely understood as an integrated network of redox reactions, energy conservation, and biosynthetic pathways. Here we show that across diverse prokaryotic lineages, loss of red...

biorxiv.org

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

Archaea are the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.

‪ Archaea are the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.

Archaea the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.

A Bactericidal Phospholipase from Archaea

Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...

biorxiv.org

@alexdemendoza.bsky.social what’s the methylome of this thing?

Quite refreshing to read the words “out playing a defensive shot”…

The public get to vote? I guess it’s a straight shoot out between Dietmar Hamann and Creature McCreatureface.

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

We are looking for a new colleague to join us in Galway. The position is in Biochemistry and if research focus lines up we hope the successful person will join us in the Centre for Chromosome biology (chromosome.ie). Reach out if you are interested in applying! tinyurl.com/2jy4rj3r

The original figures were installed in the 17th century and removed during renovation work in the 1820s. One was later discovered in the President’s Garden; the others remain unaccounted for. Read more: www.trinity.ox.ac.uk/news/trinity...