Okamoto, @clarissacoveney.bsky.social Ganapathee & @tdcapellini.bsky.social evaluated early skeletal development for differential gene activity between humans and chimpanzees, suggesting a complex, polygenic basis for human skeletal evolution. 🔗 doi.org/10.1093/gbe/evag121 #genome #evolution

Great work on the genetics of osteoarthritis by my post-doc Dr. @clarissacoveney.bsky.social and lab: acrjournals.onlinelibrary.wiley.com/.../art.43231

1) Despite the chaos, I am very pleased to present the terrific research conducted by my post-doc @clarissacoveney.bsky.social. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk

Objectives To reveal causal level osteoarthritis (OA) disease biology by targeting regulatory interactions at GDF5. Methods By investigating different GDF5 regulatory regions (R2, R3-5, R7-R9, R18...

acrjournals.onlinelibrary.wiley.com

Last year’s electoral earthquake exposed the difficulty the Democratic Party faces in building a majority for the age of populism. Henry wrote for @AmericanAffrs about liberalism’s transformation, grand ambitions constrained, and what comes next. Read here americanaffairsjournal.org/2025/02/the-...

The Rise and Fall of the New Liberals: How the Democrats Lost Their Majority - American Affairs Journal

Since the 1960s, the Democratic Party has transformed. From a party rooted since the New Deal era in both “developmental liberalism” and a version of social democratic class politics, it has grown int...

americanaffairsjournal.org

Epic #fortisnet talk today with brilliant @clarissacoveney.bsky.social Ancient selection & complex regulatory interactions @ GDF5 locus shape joint morphology & OA risk 🦴👏 Marvellous discussion 2 Huge thnx for visiting us ❤️@sotonbiosciences.bsky.social for sharing and Angus Wann for chairing!!

Sounds like a plan www.thelondoneconomic.com/politics/aus...

I’ve put together a thread of pieces I’ve written about American history and political culture over the past couple of years. Please take a look and read below! ⬇️ For @time-magazine.bsky.social, I wrote about the Democratic Party’s class realignment. #2024Election time.com/7173651/demo...

The Democratic Party Realignment That Empowered Trump

Since the 1970s, the Democratic Party has realigned—a shift that might have cost Kamala Harris the White House.

time.com

I have started an Orthopaedic Research Starter Pack! Link: go.bsky.app/61hCir6. I am happy to add people -- comment below to be added!

JUST IN: Former GOP Rep. Matt Gaetz is withdrawing from consideration to be President-elect Donald Trump's attorney general. cnn.it/4fEA1IY

Nice watching traffic on here pick up! For anyone interested in a #zebrafish PhD we’ve got a fully funded one with @grainofscience.bsky.social on colgalt2 in fish www.swbio.ac.uk/animal-behav... come and join our friendly group in lovely Bristol

To help connect researchers in the #osteoarthritis #musculoskeletal and #ortho fields, @kelseyhcollins.bsky.social and I have started an MSK Research Starter Pack. It’s early days, but please me know if you want to be added! go.bsky.app/DJVukXR

A starter pack of scientists working in molecular evolution and population genetics, with an emphasis on the human and virological. go.bsky.app/2xnyMrS

1/9 I am pleased to present the manuscript by my terrific post-doc @clarissacoveney.bsky.social on complex regulatory interactions at the GDF5 locus and its implications for understanding musculoskeletal trait disease biology. The manuscript is at: www.biorxiv.org/content/10.1...

Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk

Our ability to pinpoint causal variants using GWAS is dependent on understanding the dynamic epigenomic and epistatic context of each associated locus. Being the best studied skeletal locus, GDF5 asso...

biorxiv.org

Wondering what happened just over a week ago? Look up Henry Tonks' (@henrymjtonks, linkedin.com/in/henry-tonks-345300338) TIME piece highlights shifts in the Democratic Party and who it is perceived to cater for. time.com/7173651/demo...

The Democratic Party Realignment That Empowered Trump

Since the 1970s, the Democratic Party has realigned—a shift that might have cost Kamala Harris the White House.

time.com

Our latest update on the GDF5 story is now live! Here we highlight the importance of considering regulatory interactions and local epistasis in understanding the impact of GWAS variants of high significance. doi.org/10.1101/2024... @tdcapellini.bsky.social Repost from twitter

We are advertising a fully funded PhD project starting September 2025. We’ve been excited for this for a long time- biologically unravelling the results of genetic studies to understand the mechanism of cartilage breakdown conferred by SNPs. Reach out if interested! www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Investigating the role of COLGALT2 in osteoarthritis using a stem cell model of cartilage health and disease at Newcastle University on FindAPhD.com

PhD Project - MRC DiMeN Doctoral Training Partnership: Investigating the role of COLGALT2 in osteoarthritis using a stem cell model of cartilage health and disease at Newcastle University, listed on F...

findaphd.com