Oral semaglutide (a GLP-1 pill) is not effective at slowing progression in patients with mild Alzheimer's disease, find the EVOKE and EVOKE+ trials. Find out more ▶️ spkl.io/633297Tzif #WorldAlzheimersDay

The field of Alzheimer’s disease has seen transformative advances that are beginning to reshape clinical practice. On #WorldAlzheimersDay, read a Seminar summarising the progress made and highlight the unmet needs and priorities for future research: spkl.io/633297Tz97

🆕 New Lancet Commission: pandemic readiness needs a whole-of-society overhaul—not just formal plans on paper. 10 recommendations, 6 foundational blocks. Read more: tinyurl.com/465yd7se

The NUS–Lancet PRIME Commission: transforming pandemic readiness for equity

The National University of Singapore (NUS)–Lancet Pandemic Readiness through Institutions, Mobilising Communities, and Equity (PRIME) Commission redefines pandemic readiness

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Blood test can identify signs of Alzheimer’s Disease decades before symptoms, suggests study in The Lancet. Find out more: spkl.io/633277ruqv #WorldAlzheimersDay

ICYMI - A Series in @thelancetneuro.bsky.social explores how Alzheimer's disease clinical practice might evolve over the next 5–10 years, focusing on: ➡️ fluid biomarkers ➡️ neuroimaging ➡️ clinical pathways for cognitively unimpaired individuals Read now: spkl.io/633277rPsR #WorldAlzheimersMonth

What if cancer prevention were as personalised as cancer treatment? The @gustaveroussy.fr–Lancet Lecture sets out the case for precision prevention & early detection—matching interventions to individual risk, while building the workforce & health systems needed to deliver them. spkl.io/633267rFOk

Despite serious symptoms, asthma is often underdiagnosed and mismanaged, which—in the worst-case scenarios—can be fatal. A new Editorial explores the unmet needs of people living with severe asthma: spkl.io/633287rIyo

What makes a meta-analysis believable? In our latest issue, a new Viewpoint outlines how to identify meta-analyses that merit clinical confidence. Explore the full issue: spkl.io/633277rxvt

ICYMI - A genetically modified pig kidney kept a man off dialysis for nine months before a successful human kidney transplant, according to a world-first report in The Lancet. Read now: spkl.io/633257r8p1

⏰ Get writing—less than a month left to enter the 2025 Wakley Prize competition! Find out more about this year's theme: spkl.io/6332778MJb

A new AI tool could help doctors avoid unnecessary contrast-dye injections for some brain tumour patients, according to a study in @lancetimaging.bsky.social Explore the research 👉 tinyurl.com/2uufu6ur

Predicting brain tumour enhancement from non-contrast MRI with artificial intelligence: a multicohort, retrospective, diagnostic accuracy study

Deep learning can identify contrast-enhancing brain tumours from non-contrast MRI. These models show promise as a triage or decision-support aid—for example, flagging studies in which post-contrast en...

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New paper out in @thelancet.com! In >4,000 people with Down syndrome, we show when epilepsy emerges and its clinical impact. Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study - The Lancet www.thelancet.com/journals/lan...

Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study

Epilepsy increases sharply after symptomatic Alzheimer's disease onset in people with Down syndrome. The association of epilepsy with reduced survival and accelerated cognitive decline underscores the...

thelancet.com

What we eat and where we live have long been understood as determinants of health. But what we scroll, what algorithms feed us, and how platforms are designed are determinants of health too. Join us and @dthlab.bsky.social for the launch of a new Lancet Series ➡️ spkl.io/633247rMJu

🤖Digital determinants of health – want to hear from Series authors why it matters? Join Series authors representing 13 global experts. Register now for - Unsafe by design- webinar– co-hosted by DTH-Lab & @thelancet.com . Register: https://tr.ee/iY3uhd

A new study assessed the efficacy & safety of mitapivat in adults with transfusion-dependent thalassaemia. The study found that mitapivat significantly reduced the transfusion burden & was generally well tolerated, showing a favourable benefit–risk profile. Read: spkl.io/633207r84y

New US Medicare pricing policies could reshape global pharmaceutical markets, potentially driving up prices and delaying medicine launches worldwide, study suggests. Find out more: spkl.io/633247RvuC

Register to join Suzette Delaloge, Medical Oncologist and Researcher at Gustave Roussy, who will provide opening remarks and join a panel discussion at the inaugural Gustave Roussy–Lancet Lecture. 18 Sept | Paris + online Register: spkl.io/633287yTpp

New Editorial—Gene-editing therapies: delivering safely for patients spkl.io/633227Rs3G

In July, the winners of the Lancet–Elsevier Foundation Evidence to Impact Awards were announced. Three research teams were recognized for outstanding work translating health evidence into real-world impact in underserved communities. Find out more about their work in The Lancet ⤵️

On the cover this week, authors of a new letter argue that global science can serve as a foundation for international cooperation, even when politics fails. Read this & more: spkl.io/633227RSlM

In @thelancetneuro.bsky.social, a new Series explores how Alzheimer's disease clinical practice might evolve over the next 5–10 years, focusing on: ➡️ fluid biomarkers ➡️ neuroimaging ➡️ clinical pathways for cognitively unimpaired individuals Read now: spkl.io/633207R5si

🆕 The Lancet Regional Health - Eastern Mediterranean has published its first piece of content online 📝 Farida Abougaziaa & Mohamed Salama discuss the overlooked mental health needs of older refugees in Egypt and the broader Eastern Mediterranean Region: spkl.io/633267RVvi

A genetically modified pig kidney kept a man off dialysis for nine months before a successful human kidney transplant, according to a world-first report in The Lancet. Read now: spkl.io/633247RJgK

In The Lancet Surgery & Anaesthesiology, Debra Leung and colleagues explore perioperative shared decision making through a global equity lens. Read now: tinyurl.com/myyb8h4y

According to a new analysis published in @thelancetph.bsky.social, more than 2.7 billion people were exposed to second-hand smoke in 2023, contributing to nearly 1.7 million deaths. Explore the research: spkl.io/633247uhge #GBD @ihmeuw.bsky.social

🫁 Lung cancer remains the leading cause of cancer-related death worldwide. A new Lancet–@lancetrespirmed.bsky.social Series, presented at #ERSCongress, evaluates the evolving therapeutic landscape across the major subtypes of lung cancer: spkl.io/633247uqza @europeanrespsoc.bsky.social

Stereotactic body radiation therapy (SBRT) is the standard of care for early-stage, medically inoperable non-small-cell lung cancer (NSCLC). A new trial investigated the addition of atezolizumab with SBRT. Find out more: spkl.io/633217uhKL #ERSCongress @europeanrespsoc.bsky.social

How will the Meta settlement affect child health? Find out more in a new World Report: spkl.io/633277uWnL

Uptake of robotic-arm-assisted total knee replacement is increasing rapidly worldwide. Yet whether robotic systems improve outcomes is uncertain. A study investigated clinical efficacy & cost-effectiveness of Mako robotic-arm-assisted TKR versus conventional TKR: spkl.io/633237uWtL

A new @thelancet.com publication co-authored by Senior Adviser @bethcameron-dc.bsky.social focuses on practical recommendations for creating & sustaining financing for medical countermeasures for any major disease emergency. Experts agree: the time to act is now www.thelancet.com/journals/lan...

Closing the preparedness gap: moving beyond emergency response to sustain the medical countermeasure ecosystem

Infectious disease outbreaks expose weaknesses that are overlooked between crises. The ongoing Ebola virus disease outbreak caused by Bundibugyo virus (Orthoebolavirus bundibugyoense; BDBV) in the Dem...

thelancet.com