🎉Out now in Nature Metabolism: "The Hallmarks of Skeletal Muscle Health" (Ruas). Dr. Ruas and his co-authors hope that this framework provides a common language for studying muscle across health, aging, and disease, while helping to connect mechanistic biology with clinically meaningful outcomes.🧠🫀

🔔Don't miss out — stay connected!🧑‍💻 Dive into the Frankel IHBH News archive and discover impressive featured publications, throwback newsletters, and must-read articles. Check it out! 🫀🧠🔬

Frankel IHBH News | University of Michigan Medical School

News from Frankel IHBH

medresearch.umich.edu

🧬🔔New in Med! Plasma proteins help explain how diabetes, hypertension & dyslipidemia drive heart, kidney, nerve & lung disease. This research may lead to better ways to predict disease progression, detect problems earlier, and develop more targeted treatments. (Wang & Rosenzweig)🫀🧠🔬

Plasma proteomics linking primary and secondary diseases: Insights into molecular mediation from UK Biobank data

Hanyu Qian 1 2 3, Chao Wu 1 3, Bo Li 1, Anthony Rosenzweig 1, Meng Wang 1 2 4

sciencedirect.com

🎉Congratulations to Nathan Navarre on his impressive presentation at the 2026 Frankel CVC SURF end-of-summer symposium! Nathan spent the past 10 weeks in the Rosenzweig Lab, mentored by Dr. Chao Wu.🔬🫀🧠 @drchaowu.bsky.social @anthony-rosenzweig.bsky.social

💭🔬 Looking to learn more about the Frankel IHBH and its Labs? Check out our website!🧑‍💻🌐

Frankel IHBH | University of Michigan Medical School

Enhancing the Michigan Medicine Research Community

medresearch.umich.edu

The Frankel IHBH and Biointerfaces Institute have launched the Brain-Body Crosstalk in Health and Disease Challenge!🎉💸 A new funding opportunity supporting translational research at the interface of brain health and whole-body physiology.🔬 Read the full article below!

Brain-Body Crosstalk in Health and Disease: Multidisciplinary Pilot Awards and Challenge Symposium

The Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) and the Biointerfaces Institute (BI) have launched the Brain-Body Crosstalk in Health and Disease Challenge.

medresearch.umich.edu

🔔 🗣️Dr. Rosenzweig was a featured speaker at the #AmericanHeartAssociation/Bugher Foundation symposium, Reimagining Stroke as a Systemic and Progressive Disease, where he led a moderated discussion titled "Stroke and the Body: Implications for Acute Care and Directions for Future Research." 🫀🧠 #AHA

🔔 On May 28, the HyperMet Research Network hosted Dr. Jorge Ruas for a talk titled "Muscle-driven factors in the control of systemic bioenergetics: A role for the immune system?" Read the summary below! 🗣️🫀🧠

Lecture by Jorge L. Ruas

We use Google for our search. By clicking on „enable search“ you enable the search box and accept our terms of use.

web.tum.de

Our latest issue of Cardio-Cognition Quarterly is here! 🎉🫀🧠 🔔Click the link to see our recent announcements and highlights!🖱️‼️

Cardio-Cognition Quarterly

Summer 2026 | V.8

mailchi.mp

We are pleased to welcome 2026 Frankel CVC SURF Program fellow Nathan Navarre to the Rosenzweig Lab!🎉Nathan will be working with and mentored by Dr. Chao Wu during his 10 weeks in the undergraduate research fellowship program.🧠🫀🔬 @drchaowu.bsky.social @anthony-rosenzweig.bsky.social

🎉During the 6th Annual 2026 Neuroscience Conference, Ruas Lab PhD students, Avery Campbell & Rafael Hoyos Justiniano, presented their projects: “Exploring Neurturin as a Therapeutic for Amyotrophic Lateral Sclerosis” “Exploring the role of the RNA-binding protein ZFP697/ZNF697 in neuroinflammation”

Supplementing with peptides: Good for extra pep or a needless step? 🤔💭 🔔Check out the article below featuring Jorge Ruas, PhD, PharmD, where he talks about peptides, how they work and whether supplementing them lends any benefit. 🗣️ @ruaslab.bsky.social

Supplementing with peptides: Good for extra pep or a needless step?

Health Lab talks to Jorge Ruas, Ph.D., of the U-M Department of Pharmacology, about peptides, how they work and whether supplementing them lends any benefit.

medresearch.umich.edu

🗣️💬Thank you to everyone who attended the Frankel IHBH Inaugural Speaker Series featuring Filip Swirski, PhD, from Mount Sinai. Dr. Swirski presented his talk “A cholesterol handling macrophage circuit that modulates cardiometabolic disease” along with a story about heart-brain connections. 🫀+🧠

Thank you to everyone who made the Spring AHA SFRN on Inflammation meeting at the University of Michigan a success!🎉We’re grateful to the American Heart Association for supporting the outstanding science and collaboration emerging from this Network.🫀🧠 #AmericanHeartAssociation

Thank you to everyone who made the Spring AHA SFRN on Inflammation meeting at the University of Michigan a success!🎉We’re grateful to the American Heart Association for supporting the outstanding science and collaboration emerging from this Network.🫀🧠 #AmericanHeartAssociation

On Saturday, May 16, the Frankel IHBH team participated in the 2026 Washtenaw County Heart and Stroke Walk & 5K!🫀🧠🏃‍➡️The walk raised over $257,000 to support lifesaving research and education for heart disease and stroke. Thank you to everyone who participated!🎉#HeartWalk #AmericanHeartAssociation

🔔Check out the recent issue of the Cardio-Cognition Newsletter from the Frankel IHBH! 🧠🫀 Featuring highlights from our faculty, labs, and the Michigan Medicine community!🎉 @anthony-rosenzweig.bsky.social

Frankel IHBH Cardio-Cognition Spring Issue

Spring Issue | V.7

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Today!🎉📢 The Frankel IHBH is hosting its Inaugural Director’s Speaker Series with a lecture by Filip K. Swirski, PhD, Director of the Cardiovascular Research Institute at Icahn School of Medicine at Mount Sinai. We hope to see you there!🫀🧠

Today!🎉📢 The Frankel IHBH is hosting its Inaugural Director’s Speaker Series with a lecture by Filip K. Swirski, PhD, Director of the Cardiovascular Research Institute at Icahn School of Medicine at Mount Sinai. We hope to see you there!🫀🧠

Michigan Medicine community! 📢 The Frankel IHBH is hosting its Inaugural Director’s Speaker Series with a lecture by Filip K. Swirski, PhD, Director of the Cardiovascular Research Institute at Icahn School of Medicine at Mount Sinai. See the attached flyer for the full event details! 🧠🫀🎉

📖🎉Check out the full story highlighting the recipients of the Heart-Brain-Diabetes Interdisciplinary Studies program from the Frankel IHBH, Caswell Diabetes Institute, and the Michigan Diabetes Research Center!🫀🧠🔬

Heart-Brain-Diabetes Interdisciplinary Studies Program Recipients

The Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH), Caswell Diabetes Institute (CDI), and the Michigan Diabetes Research Center (MDRC), are delighted to announce the…

medresearch.umich.edu

🎉Congrats to Aurel Leuchtmann, PhD (Ruas Lab), inaugural Frankel IHBH Postdoctoral Fellow! Awarded annually, this fellowship supports innovative heart/brain health research. His work aims to guide pharmacological and non-pharmacological ways to prevent, halt, or reverse heart remodeling.🫀🧠

Frankel IHBH Inaugural Postdoctoral Fellowship Award 2026

The Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) is proud to announce Aurel B. Leuchtmann, Ph.D., as the inaugural Frankel IHBH Postdoctoral Fellow.

medresearch.umich.edu

🎉Congrats to Aurel Leuchtmann, PhD (Ruas Lab), inaugural Frankel IHBH Postdoctoral Fellow! Awarded annually, this fellowship supports innovative heart/brain health research. His work aims to guide pharmacological and non-pharmacological ways to prevent, halt, or reverse heart remodeling.🫀🧠

Frankel IHBH Inaugural Postdoctoral Fellowship Award 2026

The Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) is proud to announce Aurel B. Leuchtmann, Ph.D., as the inaugural Frankel IHBH Postdoctoral Fellow.

medresearch.umich.edu

🫀🧠100’s of new candidate biomarkers and therapeutic targets linking heart and brain disease in: “Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease” (Wu; Li) (Nature Cardiovascular Research) Look up your favorite protein and share it with us! 🔬

Proteomics Research Portal

Search and explore proteomics association and MR causal relationship analysis results

proteomics-hbi.vercel.app

Out now!🎉Congrats to Chao Wu, MD, PhD (Rosenzweig Lab) and partners incl. Chunyu Li (Wang Lab) on “Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease” (Nature Cardiovascular Research) The study maps heart-brain links via plasma proteins as biomarkers.

Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease

Mapping Molecular Links Between Heart and Brain Disease

nature.com

🫀🧠100’s of new candidate biomarkers and therapeutic targets linking heart and brain disease in: “Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease” (Wu; Li) (Nature Cardiovascular Research) Look up your favorite protein and share it with us! 🔬

Proteomics Research Portal

Search and explore proteomics association and MR causal relationship analysis results

proteomics-hbi.vercel.app

Out now!🎉Congrats to Chao Wu, MD, PhD (Rosenzweig Lab) and partners incl. Chunyu Li (Wang Lab) on “Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease” (Nature Cardiovascular Research) The study maps heart-brain links via plasma proteins as biomarkers.

Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease

Mapping Molecular Links Between Heart and Brain Disease

nature.com

The Challenger Foundation Career Development Award inaugural recipient Dr. Qiulian Zhou, PhD, will use genetic models to study why HFpEF affects women more. This award is aimed to accelerate cardiovascular research and career development, focusing on sex-based disparities in heart disease.

The Frankel IHBH, Elizabeth Weiser Caswell Diabetes Institute, and the Michigan Diabetes Research Center, are delighted to share the winners of the Heart-Brain-Diabetes Interdisciplinary Studies Program: Nadejda Bozadjieva Kramer, PhD and Roger L. Albin, MD Jun Wu, PhD and Alison Affinati, MD, PhD

Avery Campbell, Pharmacology PhD student in the Ruas Lab, co-authored a publication titled “Novel histone deacetylase inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis.” Her research centers on the exploration of the myokine, Neurturin, as a potential therapeutic for ALS.

Novel histone deacetylase inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis - PubMed

CS014 represents a novel HDAC inhibitor with the potential for reducing hepatotoxicity while maintaining the benefit of preventing injury-induced clotting without increased bleeding diathesis.

pubmed.ncbi.nlm.nih.gov