How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work! www.nature.com/articles/s41... www.nature.com/articles/s41...

Target cell cortical tension regulates macrophage trogocytosis - Nature Cell Biology

Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...

nature.com

Don't miss the morphological transformation pDC → tDC → cDC2 on the cover of Nature Immunology! www.nature.com/ni/volumes/2...

Idoyaga Lab@idoyagalab.bsky.social · 12mo ago

Our paper made the cover of Nature Immunology’s September issue! 🎉 Aren’t dendritic cells beautiful? 😍 SEM shows pDCs as they switch identity into cDC2-like cells. Congrats to the whole team! 👏 🔗 www.nature.com/ni/volumes/2...

Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells

Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....

rdcu.be

Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!

Idoyaga Lab@idoyagalab.bsky.social · last yr.

🚨 Our latest paper is out in @natimmunol.nature.com ! 🧵 Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity! Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏 🔗 www.nature.com/articles/s41...

Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation! doi.org/10.1038/s415... #pDC #APC #TNF #IFN-I #immunosky

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology

Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...

doi.org