A study in PNAS describes how hypoxia and elimination of peroxisomes drives HCC dedifferentiation. RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation. www.proteinatlas.org/news/2026-08...

Saliva is a combination of enzyme-rich secretions from serous acini and mucin-rich secretions from mucus acini. Using mIHC/IF the regulator of acinar cell functions, BHLHA15 (green) is shown in the nucleus of serous acini (cyan) within the salivary gland. www.proteinatlas.org/news/2026-07...

Mitochondria go where they are needed Mitochondria do a lot more than ATP production. The positioning of mitochondria within cells is regulated and dynamic and their direct interactions with other organelles can regulate many cellular processes. Read more www.proteinatlas.org/news/2026-07...

Transcription factor FOXJ1 (magenta) and chromatin regulator HMGN3 (green) display different nuclear staining in the fallopian tube. FOXJ1 stains a subset of the cells in the fallopian tube epithelium while HMGN3 shows a more general staining pattern. www.proteinatlas.org/news/2026-07...

A study in Nature suggests ALDH18A1 and ferroptosis as a therapeutic target for cancer treatment. Inhibition of ALDH18A1 suppressed livercarcinogenesis through depletion of spermine (essential for cellular homeostasis) and activation of ferroptosis in HCC. www.proteinatlas.org/news/2026-07...

In this episode of Proteins Unfolded Evelina Sjöstedt, head of HPA Single cell analysis talks about the transcriptome in the context of the genome and proteome. She discusses her current research at The Human Protein Atlas and single cell transcriptomics. www.proteinatlas.org/news/2026-06...

In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn. www.proteinatlas.org/news/2026-06...

Glycolysis-associated enzyme PKLR highlighted in cytoplasm of proximal tubular cells (green) in the kidney using multiplex immunohistochemistry. Other highlighted kidney structures are Distal tubules (red), podocytes (yellow) and endothelial cells (magenta). www.proteinatlas.org/news/2026-06...

In version 25.1 of the Human Protein Atlas, a dataset based on Deep Visual Proteomics has been integrated in the Single Cell resource to provide mass-spectrometry based proteomics at an unprecedented resolution across cell types and tissues. www.proteinatlas.org/news/2026-05...

A study by HPA researchers in Nature Communications presents a high-resolution spatial map of proteins associated with motile cilia in the human fallopian tube, providing new insights into reproductive biology, infertility and cilia-related disease. www.proteinatlas.org/news/2026-05...

The Human Protein Atlas welcomes GeneTex’s recent announcement formalizing a collaborative relationship with the Human Protein Atlas. Collaborations with Atlas Antibodies, NCI-CPTC, Thermo Fisher Scientific, and Absea Biotech are also acknowledged. www.proteinatlas.org/news/2026-05...

The differences in blood protein levels during childhood and early adulthood were recently explored in an article published in Nature Communications, which highlighted the importance of accounting for age and sex when analysing protein levels in children. www.proteinatlas.org/news/2026-05...

SON and SRRM2 are essential for forming nuclear speckles and in a study in Cell it was shown that their simultaneous depletion resulted in complete dissolution of speckles, disturbing 3D-genome organization and H3 isochore gene expression. www.proteinatlas.org/news/2026-04...

In a review article published in Pharmacological reviews the current knowledge regarding structure, function, opportunities for therapeutic targeting and distribution in tissues and cells of human and mammalian aGPCRs is summarised. www.proteinatlas.org/news/2026-04...

A mIHC/IF panel is used to identify proteins expressed at specific stages of spermatogenesis. Here BEND2 is shown in the nucleus of cell state 2 spermatocytes (green) together with state 3 spermatocytes (magenta) and early (white) and late (red) spermatids. www.proteinatlas.org/news/2026-04...

In the episode 102 of the Proteomics show podcast series, "All the parts", neuroscientist at Karolinska Institute and HPA researcher Jan Mulder talks about different aspects of the brain and brain research together with the hosts Benjamin Neely and Ben Orsburn. www.proteinatlas.org/news/2026-04...

Easter celebration is very tightly linked to eggs and therefore we will take this opportunity to have a closer look at the zona pellucida proteins, some of the most important genes in the human oocyte. www.proteinatlas.org/news/2026-04...

Using mIHC/IF the adaptor protein SHC2 involved in cell signaling is shown in green in the cytoplasm of glucagon-producing alpha cells within the islets of Langerhans in pancreas . Other visualized cell types are beta cells (magenta) and delta cells (yellow). www.proteinatlas.org/news/2026-03...

At a recent high-level international meeting in Mexico City, 600 international delegated discussed trends in education, health and research. Mathias Uhlén shared a practical perspective on what universities must do as innovation cycles accelerate. www.proteinatlas.org/news/2026-03...

In a study in J.Proteome Res >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex IHC. The high-resolution data aids in further functional mapping of proteins with limited evidence. www.proteinatlas.org/news/2026-03...

A study in Science demonstrate that STING acts as a molecular barrier to bird flu and that a single substitution in the viral M1 protein leads to human IAVs evading activation of human STING, demonstrating the significance of this antiviral barrier for IAVs. www.proteinatlas.org/news/2026-03...

February has been declared the gallbladder and bile duct cancer awareness month, and features the international World Cancer Day. This year's theme was "United by Unique" to raise awareness of the disease and request a cancer care more focusing on individuals. www.proteinatlas.org/news/2026-02...

In a report published in the Journal of Proteome Research last years advances and efforts within the HUPO coordinated Human Proteome Project (HPP) to define the human proteome and make proteomics an integral part of functional multiomics are presented. www.proteinatlas.org/news/2026-02...

The spatial expression pattern of TMEM213 in ductal structures of the salivary gland, based on mIHC/IF, show localization (green) to the apical part of the membrane of large ducts (red) but not to small ducts (magenta) or serous acini (cyan). www.proteinatlas.org/news/2026-02...

The HPA primary cilia research by Hansen published in Cell has been recognized as setting a new standard for understanding ciliary function and its role in health and disease in a research highlight published in Nature Signal Transduction and Targeted Therapy. www.proteinatlas.org/news/2026-02...

Detection of cancer is challenging, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nat. Commun. plasma protein signatures was used to identify cancer among patients with non-specific symptoms. www.proteinatlas.org/news/2026-01...

Lysosomes play a central role in the controlled degradation crucial for cellular function and homeostasis. But what if the lysosomes themselves become damaged or dysfunctional? Recently a set of key players in the process called lysophagy was identified. www.proteinatlas.org/news/2026-01...

Ciliated cells are found in the endocervical epithelium in the inner canal of the cervix. Here the CAPSL gene is shown to be localized (green) to all of the annotated subcellular structures of the cervix ciliated cells except for the cilia basal body. www.proteinatlas.org/news/2026-01...

Insulin (green) is explored in endocrine pancreas using mIHC/IF and five peptide hormone markers specifically secreted by specialized endocrine cell types, including alpha cells (cyan) and delta cells (yellow) within the islets of Langerhans. www.proteinatlas.org/news/2025-12...

In PNAS researchers have used a combinatorial protein library to select binders against the cancer receptor EGFR that allow for selection of calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes. www.proteinatlas.org/news/2025-12...