Scientists have uncovered hidden genetic drivers of conditions like IBD by stimulating immune cells. 🔬 The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions. sanger.ac.uk/news_item/ac...

Activated immune cells reveal hidden drivers of autoimmune diseases

A new resource, MacroMap, provides a rich dataset that researchers can use to explore genetic mechanisms behind complex diseases.

sanger.ac.uk

Delighted to share the first preprint of my postdoc in the @carlanderson.bsky.social lab www.medrxiv.org/content/10.1...! 🚨 A super exciting study I co-led with the very talented @tobioinformatics.bsky.social . Stay tuned to see what we learned about genetic susceptibility to complex disease. 🧬🧵 1/

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

Most genetic variants associated with complex diseases lie in non-coding regions, complicating efforts to identify effector genes and relevant cell types. Here, we map cis-eQTLs across 2.2 million sin...

medrxiv.org

Preprint out today! A team led by @tobioinformatics.bsky.social and Bradley Harris in @carlanderson.bsky.social ‘s lab has created the largest single-cell atlas of IBD tissues to date www.medrxiv.org/content/10.1...