Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation. rdcu.be/fj8Er #Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu

Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology

In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...

nature.com

If you are interested in the story behind our recent study in Nature Structural & Molecular Biology, our accompanying Research Briefing discusses the questions that motivated the work, the main findings, their implications, and the path that led us there. @pasteur.fr rdcu.be/flcpv

Yolk transports miRNAs to embryos and enhances progeny stress resilience

Nature Structural & Molecular Biology - This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs,...

rdcu.be

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

nature.com

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

FlyBase secures funding for year, but future still uncertain

The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

tinyurl.com

Obituary: John Gurdon (1933-2025) Biologist who made cloning possible go.nature.com/3WicRAe

John Gurdon obituary: Biologist who made cloning possible

He showed that specialized cells retain the genes to form an organism.

go.nature.com

Feeling inspired after presenting some #3Dgenome & #single-cell data at the #EDRC2025 in the beautiful #Alicante🇪🇸🧬🪰 Looking forward to the next amazing sessions to exchange ideas and connect with the community!

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene | Science www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

science.org

If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXB

How bats developed their wings? 🦇 Turns out they reutilize existing gene programs 🔧 Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs www.nature.com/articles/s41...

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution

Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...

nature.com

Our News&views with Germano @cecerelab.bsky.social about the role of H3K27me3 in epigenetic control of piRNA transcription in worms 🪱 and flies 🪰 is out in @natsmb.nature.com rdcu.be/erkld

H3K27me3 expands the epigenetic control of piRNA transcription

Nature Structural & Molecular Biology - Constitutive heterochromatin can promote piRNA transcription, a crucial step in genome defense. Two studies now show that piRNA transcription in...

rdcu.be

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

👀 New study: The stability of circular RNAs makes them ideal for long-lasting regulatory tasks in neurons. Researchers from the @hilgerslab.bsky.social have now identified the protein ELAV protein as a master regulator of circular RNA production in the nervous system, crucial for brain function.

Running circles in my head

Researchers in Freiburg have identified the protein ELAV as a key regulator of circular RNA production in the nervous system, which is crucial for brain function.

ie-freiburg.mpg.de

The next TriRhena Gene Regulation Club takes place at the MPI-IE #Freiburg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers. 📅 16 Jun 2025 | 14:00 🎟️ Free entry, registration required ✍️ Register by: 6. Jun www.ie-freiburg.mpg.de/gene-regulat...

Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg! 📅 April 24, 2025, 14:00-19:00 PM 📌 Max Planck Institute, Freiburg (only on-site!) 🛠️ Organized by: @iovino-lab.bsky.social Register & join free of charge.

Symposium: Epigenetics of early mouse development

We are delighted to invite you to to the second symposium, “Epigenetics of Early Mouse Development”, taking place on April 24, 2025, at the Max Planck Institute of Immunobiology and Epigenetics in Fre...

ie-freiburg.mpg.de

Exciting news! Our latest work in the Nicola Iovino Lab, “Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis,” is now published in Nature Communications! www.nature.com/articles/s41...

Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis - Nature Communications

Germ layer specification during zygotic genome activation is regulated by chromatin state. Here, the authors use single-cell multiome profiling in Drosophila to show that H3K27me3 and H3K27ac at cis-r...

nature.com

About a week ago, our new story in the #IovinoLab about chromatin factors and germ layer specification during ZGA in Drosophila embryos was published! Missed it? 🔎 Check out this resume article by our Institute! #chromatin #epigenetics #development

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 2y ago

How does a single fertilized egg know how to become muscle, brain, or skin? 🤔 A new study by the @iovino-lab.bsky.social shows how epigenetic mechanisms ensure that the right genes are activated at the right time, allowing each cell to assume its designated role in the body. #drosophila #chromatin

Amazing piece of work from @ninacabezas.bsky.social Lab! Congratulations Jasmin, Mari & team!

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 2y ago

New research by the @ninacabezas.bsky.social lab & collaborators from @uniklinik-fr.bsky.social. A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.