If you predict or annotate genes from whole genomes, what would you like current software to do better? What's still missing, unnecessarily difficult, or hard to trust? I'm interested in problems that matter in real projects, including the unglamorous ones. #Bioinformatics #GenomeAnnotation

Genetic Association of Somatic Incompatibility and NLR-like Protein Domains in Coprinopsis cinerea https://www.biorxiv.org/content/10.64898/2026.06.24.733965v1

You have infinitely more in common with the average person in Cuba, Iran, Lebanon or Palestine than you have with the world’s first trillionaire.

Researchers have discovered 3 new mushroom species in the genus Inocybe from Southwestern China: 🍄 I. subtropicocinnamomea 🌲 I. biformis (found above 4000m!) 🍃 I. fulvobasalis Read more: doi.org/10.3897/myco...

At last, a pill that can PREVENT COVID after exposure to infected people buff.ly/RxebpGI Ensitrelvir cut infection from 9% to 3% in household contacts. This is the first oral post-exposure prophylaxis for COVID ever proven to work. Game changer for the immunocompromised. #medsky 😷 #publichealth

Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr

After USDA request, Indiana plant biologist locked out of lab by school

Move comes after Roger Innes complained about the government’s prosecution of Chinese postdocs

scim.ag

I feel like sick people don’t deserve to die

Thomas [DARK MODE], DO@tom.medsky.social · 3mo ago

RFK Jr. showing his eugenicist beliefs. Here he is today at The City Club in Cleveland: "The average American who died from COVID had 3.8 chronic diseases. So what was really killing them? It was almost impossible for COVID to kill a healthy person. It was killing people who were already sick."

1/ BRAKER4 hatched! The Earth BioGenome Project is on track to sequence ~1.5M eukaryotic species. Every one needs a structural annotation. No Perl monolith was going to survive that. So we rewrote BRAKER from the ground up. github.com/Gaius-August...

The long-awaited FLASH manuscript is finally out--check out some interesting results on predicting drug resistance in C. tropicalis, C. auris and other yeasts using a unique k-mer based model! www.biorxiv.org/content/10.6...

I had a great time at #FGC26. I enjoyed presenting my research on the developmental regulation of innate immunity (NLRs) and specialized metabolism in mushroom-forming fungi. Thanks to everyone who stopped by to chat. I look forward to the next one!