Trials We Love! What's happening? Merck's Phase 3 trial is enrolling young women in Kenya, South Africa, and Uganda to test whether a pill taken just once a month can prevent HIV as well as, or better than, today's daily PrEP.

HHS's Office of Inspector General asked whether federal fraud and abuse law is making it harder than it should be to pay clinical trial participants fairly.

Registration is live (both for in-person and virtual attendance) for Global Harmonization for Data Access & Exchange. @1daysooner.bsky.social supported the planning of this event, which is being hosted by the Reagan-Udall Foundation for the FDA: reaganudall.org/news-and-eve...

"The $500,000 grant to 1Day Sooner will help the group prove it can obtain the data troves of bankrupt companies, says the organization’s president and cofounder, Josh Morrison. He thinks nonexclusive copies of company datasets could be acquired for only “a few tens of thousands of dollars” each."

Highlights from our September newsletter: ➡️ 1Day Sooner was one of 128 advocacy groups who signed in support of the @americancancersoc.bsky.social Action Network letter urging for the adoption of the Clinical Trial Modernization Act. Read the letter here: www.fightcancer.org/releases/pub...

Public Health Organizations Urge HHS to Remove Financial Barriers in Clinical Trial Participation

Today, the American Cancer Society Cancer Action Network (ACS CAN), joined by 128 other patient advocacy groups, public health organizations and professional societies, submitted a letter responding t...

fightcancer.org

Tabitha Kisakye was a public health student in Uganda when she learned researchers needed healthy volunteers for a schistosomiasis study — people willing to be deliberately infected. She weighed the risks, then enrolled.

On August 14, 1Day Sooner and The Malawi Liverpool Wellcome Research Programme (www.mlw.mw) welcomed 50 clinical trial volunteers, research teams, and public officials to Blantyre, Malawi to celebrate healthy volunteers and recognize their contributions to clinical research.

Clinical trials are changing—and implementation will matter. On July 2, 1Day Sooner convened a closed-door roundtable with experts from academia, industry, and advocacy to discuss HHS’s Operation TrialBlazer, draft guidance, and pilot initiatives.

Trials We Love! What's happening? Researchers are using a carefully controlled dengue human challenge model in healthy adult volunteers to study how the virus interacts with the human immune system.

On July 30, 1Day Sooner's Participant Council met for a focus session on participant compensation — what makes it fair and how it should be calculated. The summary notes are now public. A few takeaways 🧵

We're excited to share that @coefficientgiving.bsky.social is supporting our clinical trial policy advocacy. Coefficient Giving works with a range of donors who share its commitment to cost-effective, high-impact giving.

We can cure hepatitis C, yet it still takes more years of life in Canada than any other infectious disease — and there's still no vaccine. Canada has the researchers, infrastructure, and volunteers to make one. Our latest in @healthydebate.bsky.social Read more: healthydebate.ca/2026/07/topi...

Next in our Meet the Team series: Zacharia Kafuko. Before leading 1Day Africa Zach was a biochemist in Seychelles. Early in the pandemic he read a BBC article calling for human challenge trial volunteers and that set him on the path to 1Day Sooner.

It’s #WorldHepatitisDay, and recruitment has begun in a ground-breaking study that will see participants infected with the #hepatitis C virus (and treated) – as an important first step on the road to future testing of vaccine candidates against the disease oxfordbrc.nihr.ac.uk/recruitment-... 1/2

Marcus Dahl has volunteered for two challenge trials at Oxford — deliberately exposed to COVID-19, then a new TB vaccine — so researchers could learn how to fight both.

1Day Sooner and 1Day Africa commend the University of Oxford on this major step taken by the UK in the fight against Ebola! www.bbc.com/news/article...

UK starts first vaccine trial, eight weeks into Ebola emergency

The UK medicines regulator has given approval for an experimental vaccine to be tested on healthy adults.

bbc.com

1Day Sooner joins nearly 200 orgs behind the Clinical Trial Modernization Act (S. 4440). The right to take part in research shouldn't depend on your income or your zip code. This bill clears the cost and distance barriers that keep willing participants out. #ClinicalTrials

American Cancer Society Cancer Action Network@acscan.bsky.social · 3mo ago

Nearly 200 patient advocacy, public health & health care professional orgs, including ACS CAN, sent a letter to the Senate declaring their support for the Clinical Trial Modernization Act, which would help remove cost & geographic barriers that keep patients from participating in #ClinicalTrials.

Controlled human infection (CHI) trials deliberately expose healthy volunteers to a pathogen. After surveying 70 CHI and 98 phase I participants to see what drives them, this study found that CHI volunteers are motivated more by altruism than by reimbursement.

Nearly 50M people live with hepatitis C globally, with ~1M new infections each year. Oxford's HIT Study is a major step toward an HCV human challenge model that could help test vaccines faster—and move us closer to elimination. Learn more here: communities.springernature.com/posts/the-hi...

Clinical trials can save lives from cancer. But not everyone can access them. Congress has an opportunity to change this with a new bill. Help us spread the word so more people understand why #ClinicalTrials matter and why we need Congress to pass this legislation.

Meet Elizabeth Rouha. She volunteered for a first-of-its-kind C. difficile challenge study in Leiden — and walked away with something she didn't expect: a sense that research participation can be collaborative, even empowering, rather than intimidating.

1Day Sooner is joining an Amsterdam UMC project that aims to chart a responsible path—with participants at the table from day one—toward a Lyme disease human challenge model. Press release: www.1daysooner.org/press-releas...

Our latest newsletter is out — featuring participant stories, policy updates, staff highlights, and a new opportunity to join the 1Day Sooner team. A few highlights below:

Trials We Love! What’s happening? Researchers tested an investigational EBV vaccine in healthy adult volunteers for the first time, finding it was generally well tolerated and triggered strong immune responses.

Thanks to @founderspledge.com for generously supporting this work! Learn more here: www.founderspledge.com/programs/ghd...

Strep A kills ~500,000 people a year, and a vaccine is within reach—candidates have cleared Phase 1 with no serious safety signals. We were glad to see @coefficientgiving.bsky.social announce the Strep A Vaccine Fund (coefficientgiving.org/research/ann...)

www.afrigen.co.za/news-press-r...

It's time for more Trials We Love! What's happening? A clinical trial in Melbourne is testing an mRNA vaccine designed to help the immune system fight Epstein–Barr virus (EBV), a virus that infects over 90% of adults worldwide.

Americans spend 90% of their time indoors, breathing air that's often dirtier than what's outside. The hidden cost? Asthma, COPD, heart disease, and costly outbreaks of disease.

1Day Sooner is a nonprofit that advocates for healthy volunteers in high-impact clinical trials and today we recognize the researchers and participants who make trials possible! #ClinicalTrialsDay #CTD2026