ACR Journals
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Official journals of the American College of Rheumatology: Arthritis & Rheumatology Arthritis Care & Research ACR Open Rheumatology SoMe Editor: Karen Costenbader, MD, MPH
New study shows MSC therapy alleviates systemic sclerosis, with significantly reduced skin fibrosis & stabilized lung function Integrated multiomics revealed that MSCs drive immunometabolic reprogramming by repairing oxidative phosphorylation defects in cDC2 cells and restoring immune homeostasis
Analysis of three rheumatoid arthritis cohorts found that patients with RA with similar joint involvement patterns at baseline were more likely to remain clustered together over time, suggesting joint involvement patterns may be stable phenotypes Arthritis Care & Research doi.org/10.1002/acr....
Is calprotectin assoc with clinical parameters in rheumatoid arthritis? A cross-sectional study of 4,521 Scandinavian RA patients showed plasma calprotectin is a relevant marker of inflammation in RA & assoc with autoantibody load A&R doi.org/10.1002/art.... Comparison of ESR, CRP & calprotectin
Abstracts for the ACR Convergence 2026 meeting are now available! Browse the latest research being presented at the meeting → https://acrabstracts.org/meetings/acr-convergence-2026/ ACR Convergence 2026 is Nov 6-11 in Orlando, Florida
New investigation shows colon epithelial-derived CD4+ T cells retain a tolerogenic phenotype while undergoing tissue-specific transcriptional reprogramming after entering extraintestinal sites Results suggest a mechanistic framework for gut-joint axis in spondyloarthritis doi.org/10.1002/art....
In a Swedish national cohort with newly diagnosed SLE 2006-2022, the role of oral GC exposure in organ damage differed across organ domains. For several domains, especially cardiovascular damage, GC exposure over a 3-year period was required to fully capture the association with organ damage risk
Oral glucocorticoid dose patterns and organ damage in systemic lupus erythematosus – a nationwide cohort study
Background Evaluating the relationship between glucocorticoid (GC) exposure and organ damage in systemic lupus erythematosus (SLE) is challenging since GC dose varies over time. It is unclear which ...
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New study on chronic recurrent multifocal osteomyelitis translates findings from mouse models to patients Results identify chronic neutrophil activation and upregulation of inflammatory & chemotaxis pathways as prominent features. Many of these features normalized with anti-TNF biologics
Cross-sectional study using the National Inpatient Sample 2018-2020 showed rheumatoid arthritis was associated with higher odds of discharge health resources need after orthopedic intermediate risk surgery but not composite adverse clinical events or inpatient mortality AC&R doi.org/10.1002/acr....
Rheumatoid arthritis, frailty, and outcomes of surgical hospitalizations: A national population‐based analysis
OBJECTIVE Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health o...
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Plasma proteomics study reveals distinct protein signatures associated with structural damage in ankylosing spondylitis. A 5-protein panel may help stratify patients by structural damage Arthritis & Rheumatology doi.org/10.1002/art....
Comparing TNF inhibitors and tocilizumab in a combined cohort (n=151) showed similar overall effectiveness Age at symptom onset was assoc with differential biologic response, with younger-onset disease favoring TNFi response, & older-onset disease favoring TCZ response AC&R doi.org/10.1002/acr....
A 32-year-old man presented with 3 months of low back pain. Pelvic radiograph showed millimeter-sized opacities corresponding to bone islands in the sacrum, both acetabula, pubis, & ischium, as well as both femoral heads & necks (top left). A coronal T2-weighted fat-suppressed MRI demonstrated ...
A 53-year-old woman presented with fever & right neck pain. She had a history of breast carcinoma and had undergone chemotherapy with sacituzumab govitecan, which required pegfilgrastim. Seven days after the last pegfilgrastim dose, she developed generalized fatigue, fever, and right-sided neck pain
What does the gut have to do with the heart in scleroderma? In our latest episode, Dr. Zsuzsanna McMahan discusses findings from the GENISOS cohort that shed new light on the relationship between GI and cardiac manifestations in systemic sclerosis. LISTEN → sites.libsyn.com/436041/the-g...
See what's new this week in Arthritis Care & Research: Generative AI use among reproductive-age women with systemic autoimmune and rheumatic diseases doi.org/10.1002/acr.... Safety of concomitant colchicine and statin therapy doi.org/10.1002/acr.... ...
Your weekly recap of new research in Arthritis & Rheumatology Case report: BCMA-CAR-T therapy in a patient with refractory APS doi.org/10.1002/art.... Research letter: Real-word safety data on avacopan in AAV doi.org/10.1002/art....
Mouse model explored β-TrCP2 in bone homeostasis & potential as therapeutic target for osteoporosis Results showed β-TrCP2 regulates osteoclast formation by modulating IKKε–IRF3–IFNβ & NF-κB signaling pathway and influences osteoblast activity by β-catenin accumulation A&R doi.org/10.1002/art....
Retrospective cohort study evaluated muscle- & liver-related outcomes assoc w/ concomitant colchicine–statin therapy Colchicine-statin therapy was linked to more frequent biochemical abnormalities, but only a modest increase in risk compared with statin therapy alone AC&R doi.org/10.1002/acr....
📰 Breaking news: ACR Convergence 2026 abstracts are now available! We are proud to have accepted nearly 3,000 abstracts this year. Browse the cutting-edge science → acrabstracts.org ACR Convergence will be held November 6-11 in Orlando, Florida. Learn more → rheumatology.org/annual-meeting
New Immunology for the Rheumatologist review in A&R: T cells in SLE and their contribution to disease pathogenesis and organ damage doi.org/10.1002/art.... Aberrant T cell function contributes to tissue damage and increased susceptibility to infection in SLE T cell-targeted therapeutic strategies
October A&R Clinical Connections (2 of 2) Dual-Targeting BCMA–CD19 CAR-T Cell Therapy in SLE Key Points • Dual-targeting CAR-T therapy was associated with deeper depletion of plasma-lineage compartments compared to single-targeting therapy. ...
October A&R Clinical Connections (1 of 2) Functional Impact of Structural Damage in Psoriatic Arthritis Key Points • Structural damage affects physical function independently of disease activity and demographics in PsA. • Severity of joint damage matters more than its mere presence, ...
October A&R - In This Issue: •Long-Term Osteoporosis Progression With DMARDs •Baricitinib Response in Lupus Endotypes •Molecular Endotypes in SLE: CV Risk and LN Insights →Journal Club: Ixekizumab + Tirzepatide in PsA with overweight or obesity acrjournals.onlinelibrary.wiley.com/doi/epdf/10....
In this month's issue of Arthritis Care & Research, we present a collection of special articles celebrating 50 years of pediatric rheumatology and the advancements in care that have been achieved. Read the October issue: acrjournals.onlinelibrary.wiley.com/toc/21514658...
Cross-sectional survey of women ages 18-48 with diverse systemic autoimmune and rheumatic diseases assessed their use of and receptivity to current and hypothetical generative AI tools for health information-seeking Arthritis Care & Research doi.org/10.1002/acr....
Two articles in ACROR report data from the Canada-Netherlands Understanding Childhood Arthritis Network (UCAN) CAN-DU & CURE study Analyses examine work & activity impairment across JIA subtypes doi.org/10.1002/acr2... and the health burden of caregivers of children with JIA doi.org/10.1002/acr2...
First case report of BCMA-directed CAR-T therapy for severe, refractory antiphospholipid syndrome. The patient had triple-positive APS with recurrent, life-threatening diffuse alveolar hemorrhage despite rituximab and high-dose GCs. BCMA CAR-T therapy resulted in a rapid clinical response...
Data collected from 84 rheumatologists and 511 patients in the US with Sjögren's disease in 2018 shed light on the patient journey, clinical, and patient-reported burden of Sjögren's disease ACR Open Rheumatology doi.org/10.1002/acr2... Figure: Patient journey to diagnosis
Retrospective study assessed efficacy of IL-1i, IL-6i, TNFαi, or JAKi therapy for VEXAS among 52 patients seen through Aug 2024. IL-6i and JAKi therapies demonstrated limited, unsustained efficacy, while IL-1i and TNFαi therapies were not efficacious ACROR doi.org/10.1002/acr2...
Research published in Arthritis & Rheumatology reveals that an updated COVID-19 shot is beneficial for those with #autoimmune rheumatic disease. The findings are covered by HealthDay: https://bit.ly/4yKib0x September is Rheumatic Disease Awareness Month (#RDAM) 💜 @acr-journals.bsky.social
Updated COVID-19 Shot Beneficial for Those With Autoimmune Rheumatic Disease
MONDAY, Sept. 14, 2026 (HealthDay News) -- Among patients with autoimmune rheumatic disease, the odds of COVID-19-related hospitalizations are reduced among tho
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Differences in organ involvement and predictors of treatment response in a multiethnic cohort of patients with IgG4-related disease ACR Open Rheumatology doi.org/10.1002/acr2...
