Excited to share our paper out today in @science.org! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4) www.science.org/doi/10.1126/...

Disordered protein LAT encodes relative levels of signaling pathways in T cell activation

The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell ...

science.org

New in Science from the Shalek Lab: a screen of 132 versions of the T cell protein LAT shows it keeps immune signals in balance. Disrupting any one part weakens all downstream pathways together, helping T cells avoid faulty responses. https://ow.ly/zGLw50YOFFR