Tessera

ADA Professional Publications

@adapubs.bsky.social

Diabetes, Diabetes Care, Diabetes, Obesity & CardioMetabolic Care, books & podcasts—are leading sources on diabetes research, care, prevention & treatment.

576 Posts105 Follower 36 Folgt

ADA Professional Publications @adapubs.bsky.social · 4h ago

In people with non-healing diabetes-related foot ulcers, 4 weeks of combined micronutrient supplementation did not improve wound healing at 12 weeks. @UWAresearch Read here ➡️ doi.org/10.2337/doc26-0017

A flowchart titled "VitAFOOT" outlines a study on diabetes-related foot ulcers. It shows two groups: one with 49 participants receiving a combination of vitamin C, vitamin A, and zinc supplementation, and the other with 49 participants receiving a placebo. Both groups were treated for 28 days. At 12 weeks, the first group had a 100% wound area reduction median, while the placebo group had a 75% reduction median. The chart mentions regular debridement, dressings, glycemic management, antibiotics if necessary, and revascularization as part of foot ulcer management.

ADA Professional Publications @adapubs.bsky.social · 11h ago

Intensive insulin therapy was associated with a reduction in retinopathy and albuminuria in 2,761 Australian adolescents with #T1D from 1990 to 2019. Read here ➡️ doi.org/10.2337/dc26-0388

A comprehensive infographic illustrating a study on 30-year trends in diabetes complications and treatments for adolescents with Type 1 Diabetes. The image includes a data chart showing trends in complications from 1990 to 2019, with percentages of individuals experiencing complications. A multivariable GEE model highlights factors associated with retinopathy, albuminuria, and peripheral neuropathy, including mean HbA1c, insulin pump usage, and blood pressure. A conclusion notes findings supporting the targeting of modifiable risk factors and improved management outcomes. The background is light blue and includes various text boxes.

ADA Professional Publications @adapubs.bsky.social · 2d ago

Most people with diabetes are a part of the U.S. workforce, and a diabetes diagnosis or the use of insulin should not be used to determine an individual’s fitness for or ability to perform a job. ✅ Read ADA's statement 📄 : https://bit.ly/4vVZh5H ✅ Explore the collection 📚 : https://bit.ly/3STwHDr

ADA Professional Publications @adapubs.bsky.social · 2d ago

Developmental control of DNA damage responses in α- and β-cells shapes the selective β-cell susceptibility in diabetes. Read here ➡️ doi.org/10.2337/db25-1027

Diagram showing the life cycle of pancreatic progenitor cells, focusing on α-Cell and β-Cell development through various phases: embryonic, neonatal growth, mature adult, and stressed state. The illustration includes factors such as cell replication, DNA damage, replicating cell, and apoptotic cell. Arrows indicate the possible transitions between these cell states, with diabeticogenic stress highlighted in the stressed state phase. Key elements are color-coded and labeled for clarity.

ADA Professional Publications @adapubs.bsky.social · 2d ago

Greater increases in SGLT2i prescriptions occurred among Black patients, and greater increases in GLP-1 RA prescriptions occurred among those of Hispanic ethnicity at moderate cardiovascular risk. Read here ➡️ doi.org/10.2337/doc26-0027

Diagram illustrating prescribing factors for individuals with type 2 diabetes. High cardiovascular risk is on the left with strong evidence, moderate risk on the right with uncertain evidence. In the center, there's an increase in glucagon-like peptide 1 receptor agonist and sodium-glucose cotransporter 2 inhibitor prescribing.

ADA Professional Publications @adapubs.bsky.social · 3d ago

Across 4 prospective cohorts (n=3,263) including people with/without type 2 diabetes at profiling, IgG glycosylation peaks were linked to diabetic nephropathy but were less informative for neuropathy. Read here ➡️ doi.org/10.2337/dc26-0620

The image is an infographic showing a study on IgG N-glycan peaks associated with incident nephropathy. It features a flowchart detailing the study population and outcomes, including a pie chart distribution of participants. Diagrams illustrate proinflammatory and anti-inflammatory IgG N-glycan peaks. Icons of organs represent outcomes like diabetic nephropathy. A key explains the glycan color code, highlighting entities like EPIC-Potsdam and GenoDiaNaMar.

ADA Professional Publications @adapubs.bsky.social · 3d ago

Medicare's complexity creates barriers to diabetes care. This guide equips primary care teams with practical navigation strategies to optimize coverage and reduce administrative burden for patients. Read here ➡️ doi.org/10.2337/doc26-0016

Team-Based Medicare Navigation for Diabetes Care flowchart. The chart is divided into five columns: pre-visit, check-in, during visit, and post-visit. Each column lists tasks for different roles such as front office, medical assistant, clinician, and social worker or care coordinator. Tasks include verifying plans, confirming medication, updating records, and submitting requests. Key resources are listed at the bottom.

ADA Professional Publications @adapubs.bsky.social · 3d ago

Targeting VDAC1-mediated mtDNA release or using vitreous mtDNA as a biomarker may enable earlier diagnosis and novel therapeutic strategies for diabetic retinopathy. Read here ➡️ doi.org/10.2337/db26-0151

Diagram illustrating the process of neuroinflammation and retinopathy related to diabetes. It shows the VDAC1 monomer in the mitochondria and its transformation into an oligomer. Key components, such as O-GlcNAcylation, mtDNA, RIPK3, ZBP1, NLRP3, MLKL, and GSDMD, are depicted. Lines connect these entities, indicating the relationship between mitochondrial function, neuroinflammation, and retinopathy in the context of diabetes.

ADA Professional Publications @adapubs.bsky.social · 4d ago

In people without chronic kidney disease, RAAS inhibitors prevent incident albuminuria in type 2 diabetes (majority with hypertension) but showed no benefit in type 1 diabetes (all with normotension). Read here ➡️ doi.org/10.2337/doci25-0014

This image is a forest plot showing the risk ratio and 95% confidence interval for various studies comparing RASi and PBO. Each study is listed on the left with the events/total ratio. The plot includes individual studies such as ADVANCE, BENEDICT, and ROADMAP, with a pooled risk ratio indicated at the bottom. The x-axis is labeled with risk ratio values ranging from 0.1 to 10, favoring RASi and MRA on the left and PBO on the right.

ADA Professional Publications @adapubs.bsky.social · 4d ago

The “time in range” experience isn’t one-size-fits-all. In 161 adults with type 1 diabetes, personal glucose ranges were more aligned with daily symptoms and functioning than guideline-based targets. Read here ➡️ doi.org/10.2337/dc26-0603

Infographic discussing function and well-being in target versus usual glucose ranges in Type 1 Diabetes (T1D). Key points include a study of 80 adults with T1D using continuous glucose monitors (CGM). Highlights improved emotional, physical, and perceptual experiences in the target range (70–180 mg/dL). Contains statistics about study participants, such as average age, ethnicity, and CGM usage. Mentions significance of time in range (TIR) and time in personal range (TIPR) for personalized insights. Concludes that personal glucose ranges provide additional understanding beyond guideline-based target ranges.

ADA Professional Publications @adapubs.bsky.social · 5d ago

Dietary MCT supplementation may protect against hypoglycemia-related cognitive deficits in #T1D. Read here ➡️ doi.org/10.2337/db26-0293

This image is an infographic titled "Ketones Support Brain Metabolism Under Hypoglycemia in Type 1 Diabetes Mellitus." It is divided into sections: 1. Top section explains hypoglycemia in Type 1 Diabetes and proposed ketone therapy. 2. Left section, "Mechanistic Study," describes using magnetic resonance spectroscopy to measure BHB levels and its role in supporting brain metabolism. 3. Middle section, "Clinical Trial," discusses using dietary MCTs and the positive outcomes on brain metabolism. 4. Bottom section, "Conclusion," summarizes that dietary MCT supplementation increases BHB availability and may protect against cognitive deficits in Type 1 Diabetes. Abbreviations such as T1DM and MCT are used throughout.

ADA Professional Publications @adapubs.bsky.social · 5d ago

Baseline clinical, functional & psychosocial variables integrated via risk-normalized radar may guide DFU trial retention. Lower withdrawal in the smart boot group may reflect real-time adherence reinforcement. Read here ➡️ doi.org/10.2337/dc26-0658

A diagram illustrating a study on multidomain vulnerabilities and attrition in a diabetic foot ulcer trial. The study involves 210 participants, randomized into three offloading modalities: removable, some removable, and shoe. A 12-week RCT measures primary outcomes. Attrition rate is 0.81. A radar chart shows multidomain profiles, including pain, wound size, depressive symptoms, and more. Side graphs depict retention rates and factors like slow walking and depressive symptoms affecting study participation.

ADA Professional Publications @adapubs.bsky.social · 6d ago

In #T2D on insulin and #hemodialysis, %TBR was low & not affected by #rtCGM. Compared to capillary glucose testing, %TIR, mean glucose and %TAR improved during the #rtCGM intervention. Read here ➡️ doi.org/10.2337/dc26-0404

This image is an infographic about a clinical trial on real-time continuous glucose monitoring (rtCGM) for people with type 2 diabetes and end-stage kidney failure. It includes sections on the study's objective, outcomes, design, and conclusions. Bars and graphs show glycemic ranges, with multicolored sections representing the different ranges. The trial duration is noted as 180 days, with specific phases like randomization and washout. The data is presented clearly with labels and color coding for readability.

ADA Professional Publications @adapubs.bsky.social · 6d ago

Pharmacologic inhibition of TXNIP or activation of AKT ameliorates the senescent phenotype, highlighting a druggable pathway in diabetic vasculopathy. Read here ➡️ doi.org/10.2337/db25-1093

Flowchart illustrating a biological pathway. High glucose levels increase ChREBP gene activation. This elevates ChREBP and TXNIP levels, shown with red upward arrows. TXNIP positively influences AKT phosphorylation, represented by a blue downward arrow, which is inhibited by EGFR through Mig6. The process leads to cell senescence, featuring p53/p21, Mig6, SASP, Tagln, and α‑SMA, detailed in a list. An image of a blood vessel is shown at the bottom.

ADA Professional Publications @adapubs.bsky.social · 6d ago

🚨 NEW special #podcast Recorded during the 2026 Sci Sessions in NOLA! 🎙️ In this crossover episode, the ADA's podcast hosts discuss expert insights across the bench-to-bedside spectrum. Tune in! 👂 Listen at: diabetesjournals.org/journals/pages/2026_scientific_sessions_highlights_podcasts

A banner featuring the logos of the DOC Updates, Diabetes Care On Air, DiabetesBio, and The Points of CARE podcasts.

ADA Professional Publications @adapubs.bsky.social · last wk.

T2D screening in South Asian patients at lower BMI thresholds and individualized management approaches through a cultural lens should be considered. Research should be expanded in the South Asian population. Read here ➡️ doi.org/10.2337/doc26-0007

Diagram illustrating factors related to Type 2 Diabetes (T2D) in South Asian individuals, including South Asian Diet, Insulin Resistance, β-Cell Dysfunction, Thin-Fat Phenotype, Physical Inactivity, Low Body Weight, and Genetics. Each factor is connected with arrows to the central topic.

ADA Professional Publications @adapubs.bsky.social · last wk.

Post-transplant type 1 diabetes can be driven by residual recipient T cells. Islet-specific T cells were restricted by recipient-unique HLA alleles, highlighting the durability of islet autoimmunity. Read here ➡️ doi.org/10.2337/dc26-0795

Diagram illustrating a transplantation process with three sections. The first section shows a donor and recipient with an arrow indicating haploidentical hematopoietic cell transplantation. The middle section shows "Post-Transplant Chimerism" with a ratio of 99% donor T cells to less than 1% recipient T cells. A labeled "Tetramer Analysis" focuses on islet-reactive T cells of recipient origin. The final section, "Mechanistic Conclusion," depicts how autoreactive T-cell responses can influence autoimmune conditions and lymphocyte infusions, with a visual of cells interacting.

ADA Professional Publications @adapubs.bsky.social · last wk.

SGLT2 inhibitors can help prevent incident albuminuria and slow eGFR decline in people with type 2 diabetes without evidence of baseline CKD. Read here ➡️ doi.org/10.2337/doci26-0001

Flowchart illustrating the process of study identification via databases and registers. The chart includes four main sections: Identification, Screening, Eligibility, and Included. 1. **Identification**: - Records identified from Databases (n=3,829) and Other sources (n=0). - Records removed before screening include duplicate records (n=488), records marked by automation (n=0), and records removed for other reasons (n=0). 2. **Screening**: - Records screened (n=3,343). - Records excluded (n=3,257). - Reports sought for retrieval (n=86). - Reports not retrieved (n=0). 3. **Eligibility**: - Reports assessed for eligibility (n=86). - Reports excluded for Wrong Outcome (n=44), Wrong Population (n=39), and Wrong Study Design (n=3). 4. **Included**: - Studies included in review (n=0). - Reports of included studies (n=0).

ADA Professional Publications @adapubs.bsky.social · last wk.

Targeting 12/15-LO and its metabolites has the potential to protect retina against diabetes neurodegeneration. Read here ➡️ doi.org/10.2337/db26-0179

ADA Professional Publications @adapubs.bsky.social · last wk.

Real-world evidence from explorative analysis: #fearofhypoglycemia and #perceptionofhypoglycemia are not correlated with #CGM metrics in adults with #type1diabetes on #rtCGM or #HCL for one year. Read here ➡️ doi.org/10.2337/dc26-0763

The image is an infographic titled "No Correlation Between Fear or Perceived Frequency of Hypoglycemia and Time in Hypoglycemia or Other CGM Metrics in Adults With Type 1 Diabetes Using Technology." It includes two main sections: "Study Population and Design" and "Findings." The "Study Population and Design" section describes two trial groups, ALERTT1 and IN RANGE, with sample sizes and timelines for starting technology use. The "Findings" section features a scatterplot indicating no significant correlation and a note about a lack of association between fear of hypoglycemia and CGM metrics. A purple box highlights the absence of correlation between fear or perception of hypoglycemia and CGM metrics.

ADA Professional Publications @adapubs.bsky.social · last wk.

Identifying organizations that reach young adults at high risk for diabetes and have an interest in and capacity for intervention is an important first step to developing scalable, sustainable prevention interventions for this population. Read free ➡️ doi.org/10.2337/doc26-0070

Implementation Science Analysis of Potential Organizational Settings for Young Adult–Tailored Diabetes Prevention Interventions

OBJECTIVE. One-quarter of young adults have prediabetes, yet preventive interventions in this age-group face well-documented challenges with engagement. We

doi.org

ADA Professional Publications @adapubs.bsky.social · last wk.

Advances in automated insulin delivery have transformed type 1 diabetes care; future progress towards fully closed loop systems aims to reduce burden and improve equitable access. Read here ➡️ doi.org/10.2337/dci26-0051

A circular diagram titled "Diabetes Technology: Great Strides of the Past, Great Needs for the Future" is divided into "Strides of the past" and "Needs for the future." The past includes ultrarapid insulin, continuous glucose monitoring, infusion pumps, algorithm responsiveness, and accelerometry with heart rate integration. Future needs highlight adjunctive therapies, automated meal indicators, dual-hormone pumps, diabetes ecosystem access, and shared care decisions. Illustrations of people, medical symbols, and devices are around the diagram.

ADA Professional Publications @adapubs.bsky.social · last wk.

Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice. Read here ➡️ doi.org/10.2337/db26-0096

A diagram showing a timeline of an experiment with mice starting at 8 weeks old and ending at 15 weeks. It includes steps for Semaglutide injection and termination. The mice are on a chow diet throughout.

ADA Professional Publications @adapubs.bsky.social · last wk.

Children with higher genetic predisposition for carbohydrate intake consume more sugary drinks and fast-food. #ADA #foodchoices #precisionmedicine #youth Read here ➡️ doi.org/10.2337/dc25-2975

The image is an infographic titled "Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence." It features a study by Project Viva with a sample size of 516 participants. The infographic includes four sections representing life stages: early childhood, mid-childhood, early adolescence, and late adolescence. These sections contain graphs showing associations between polygenic scores for macronutrient intake and various conditions like BMI and insulin resistance. The image also highlights genetic predisposition to macronutrient intake related to sugar-sweetened beverages and has a section on gene enrichment analysis related to carbohydrate and protein intake in the brain.

ADA Professional Publications @adapubs.bsky.social · 2w ago

📚 NOW AVAILABLE: Medical Management of Type 2 Diabetes Expert authors interpret the latest research on diagnosis and classification, management, and complications of type 2 diabetes. 📖 Read individual chapters online: https://bit.ly/43QBuba 🛒 Purchase print copy: https://bit.ly/4w2Iaid

ADA Professional Publications @adapubs.bsky.social · 2w ago

Rising islet autoimmunity in Colorado birth cohorts (DAISY+TEDDY, 1993–2010). Increase seen in moderate-risk HLA, hinting at shifts in penetrance; Key environmental exposures didn’t mediate effect. Read here ➡️ doi.org/10.2337/dc26-0659

Diagram illustrating a study on increasing incidence of type 1 diabetes among Colorado children born from 1993 to 2010. The study involves two cohorts, DAISY (1993-2004) and TEDDY (2004-2010), with 892 and 1,338 participants respectively. A central graph shows cumulative incidence rates over birth cohorts BC1, BC2, BC3, highlighting an increase in incidence. An additional chart illustrates moderate-risk HLA hazard ratios. The diagram includes a mediation analysis flowchart, showing direct and indirect environmental exposure paths, noting that selected environmental exposures did not mediate the incidence increase. Key points summarize study findings, emphasizing the role of genetics and environmental triggers in type 1 diabetes.

ADA Professional Publications @adapubs.bsky.social · 2w ago

FcRn identified as a novel therapeutic target for diabetic kidney disease, offering a strategy to mitigate the substantial residual risk of disease progression despite current therapies. Read here ➡️ doi.org/10.2337/db26-0008

Diagram illustrating the impact of FcRn upregulation on podocyte injury in diabetic kidney disease (DKD). The image shows a comparison between a normal kidney and one affected by DKD. It includes illustrations of podocytes, insulin, and diabetes-related elements. Arrows indicate the increase and inhibition of specific processes, such as FcRn and insulin interactions. A section focuses on autophagy and signaling pathways, highlighting molecules like PI3K and AKT. A mouse is depicted to represent diabetes research.

ADA Professional Publications @adapubs.bsky.social · 2w ago

Is immune checkpoint inhibitors-induced diabetes always irreversible? We report a case showing clinical and biochemical recovery following treatment with infliximab. Read here ➡️ doi.org/10.2337/dc26-0700

This image presents a flowchart titled "Clinical and Biochemical Recovery of Immune Checkpoint Inhibitor-Induced Diabetes (ICI-D)." It includes diagrams of two infusion bags labeled "Ipilimumab" and "Nivolumab" connected to a person icon. The chart outlines the stages of metastatic melanoma treatment, ICI-D diagnosis, and follow-up. Key points include autoimmune responses, insulin therapy initiation, and progression towards recovery. A box labeled "Conclusion" notes potential for recovery from ICI-D, though spontaneous cases are rare. Annotations throughout provide additional details, including tests and possible long-term therapy association.

ADA Professional Publications @adapubs.bsky.social · 2w ago

📚 NOW AVAILABLE: Guide to Nutrition Therapy for Diabetes We're excited to announce the fourth edition of this essential and effective component of diabetes management. 📖 Read individual chapters online: https://bit.ly/4vtMA1T 🛒 Purchase your printed copy: https://bit.ly/4eGwVFg

Cover of the "Guide to Nutrition Therapy for Diabetes," 4th Edition, by the American Diabetes Association. It features a yellow and blue design with a honeycomb pattern and lists key topics such as integrating nutrition therapy, individualizing eating plans, using technology, dual management of obesity and diabetes, and nutrition therapy across the lifespan.

ADA Professional Publications @adapubs.bsky.social · 2w ago

🚨 NEW special DOC Updates #podcast In this special episode, @NeilSkolnik explores Lipoprotein(a)—or Lp(a)—including the guidelines and the importance of screening for this CV risk factor. 👂Listen now at: diabetesjournals.org/journals/pages/podcasts_lpa_cv_risk