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Adrian Isaacs

@adrianisaacs.bsky.social

Investigating FTD and ALS at the UK Dementia Research Institute and UCL Queen Square Institute of Neurology

14 Posts322 Follower51 Folgt
Nicol Birsa@nicolbirsa.bsky.social · last yr.

If you are looking for a PhD, are passionate about neurobiology and enjoy microscopy, come and join us for a PhD project on axonal pathophysiology in ALS! www.findaphd.com/phds/project... Applications close on Friday 4th July 2025 @mndassoc.bsky.social @uclqsion.bsky.social

Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London on FindAPhD.com

PhD Project - Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London, listed on FindAPhD.com

findaphd.com

Dementia Researcher@dementiaresearcher.bsky.social · last yr.

Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing and Alzheimer’s, using iPSC models, genomics, and molecular biology @ukdri.ac.uk @dervissalih1.bsky.social Closing date: 26th June www.dementiaresearcher.nihr.ac.uk/job/research...

Research Fellow: Immune system and Cognitive function

Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing & Alzheimer’s using iPSC models, genomics & molecular biology

dementiaresearcher.nihr.ac.uk

Adrian Isaacs@adrianisaacs.bsky.social · last yr.

We tagged C9orf72 repeat dipeptides in patient iPSC-neurons and did genetic and small molecule screens with interesting results! Huge effort from many lab members @ukdri.ac.uk‬ @uclqsion.bsky.social and @alzheimersresearchuk.org‬ Drug Discovery Institute at UCL www.sciencedirect.com/science/arti...

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons

Repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-associated non-AUG (RAN) t…

sciencedirect.com

Adrian Isaacs@adrianisaacs.bsky.social · last yr.

I recenty did a podcast about our work in the lab @ukdri.ac.uk @uclqsion.bsky.social to understand the mechanisms that cause FTD/ALS check it out here: SoundCloud on.soundcloud.com/xs6j9EcMbTRW... - Apple Podcasts podcasts.apple.com/it/podcast/n... - Spotify open.spotify.com/episode/7cnY...

Genetic Causes of ALS/FTD with Prof. Isaacs

In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns welcome Professor Adrian Isaacs (UCL), who investigates the molecular and cellular mechanisms under

on.soundcloud.com

Adrian Isaacs@adrianisaacs.bsky.social · last yr.

Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social rdcu.be/ebbZf

Neuronal polyunsaturated fatty acids are protective in ALS/FTD

Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...

rdcu.be

Adrian Isaacs@adrianisaacs.bsky.social · last yr.

A first description of the C9 repeat iNDI lines is now on bioRxiv, a collaboration from genome engineering through cell biology to facilitate ALS/FTD research @michael-e-ward.bsky.social @jacksonlab.bsky.social @cziscience.bsky.social www.biorxiv.org/content/10.1...

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD

Induced pluripotent stem cell (iPSC) models are powerful tools for neurodegenerative disease modelling, as they allow mechanistic studies in a human genetic environment and they can be differentiated ...

biorxiv.org

Adrian Isaacs@adrianisaacs.bsky.social · 2y ago

First post here! Our latest paper showing CRISPR-CasRx can target both sense and antisense C9orf72 repeats is just out! rdcu.be/d5ADQ co-led by @alexcammack.bsky.social @ukdri.bsky.social @uclqsion.bsky.social

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Nature Communications - CRISPR-CasRx effectively reduces ALS- and FTD-causing C9orf72 sense and antisense repeat derived RNAs and proteins in cell lines, patient iPSC-neurons and two independent...

rdcu.be