Complete Mutagenesis of the Genome and Proteome of ΦX174

The bacteriophage ΦX174 was the first genome to be sequenced and the first to be chemically synthesised. Here we present a complete map of the consequences of changing every nucleotide in the ΦX174 ge...

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Computational design of antimicrobial peptide nanopores - Nature Chemical Biology

A computational de novo design framework enables the design of α-helical peptides that assemble into transmembrane barrel-stave pores (TBPs). Here, TBPs are designed for antimicrobial activity, with b...

nature.com

Miniaturizing and modifying natural proteins with Raygun - Nature

Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.

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How History and Philosophy of Biology Can Change the World - Professor Gregory Radick - EHFB 2026

YouTube video by ABFHiB - História e Filosofia da Biologia

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Boolean Logic‐Based Control Over Recombinant Protein Biomaterial Degradability and Therapeutic Delivery

Fully recombinant protein-based biomaterials execute complex Boolean logic for user-programmable material degradation and concomitant therapeutic cargo release. Biologics, such as growth factors, can...

advanced.onlinelibrary.wiley.com

A spliceosome-independent eukaryote generated by complete intron removal

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

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Bacteria form ‘herds’ to survive predators, offering fresh insight into Earth’s carbon cycle

Researchers have discovered that tiny photosynthetic bacteria band together into protective 'herds' when attacked by predators - a survival strategy that could also influence how carbon is stored in t...

the-microbiologist.com

The Encyclopedia of DNA Elements

We present the Encyclopedia of DNA Elements (ENCODE), a reference map of the genomic basis of gene regulation. A product of more than two decades of systematic interrogation of genome function, ENCODE...

biorxiv.org

New CRISPR Technique Selectively Shreds Cancer Cells, Including “Undruggable” Cancers

New CRISPR Technique Selectively Shreds Cancer Cells, Including “Undruggable” Cancers - Innovative Genomics Institute (IGI)

innovativegenomics.org

Hidden cancer-associated microRNAs emerge from ribosomal DNA repeats

By revisiting ribosomal DNA spacer regions excluded from standard genome assemblies, researchers identify a new source of abundant microRNA precursors linked to cancer.

fredhutch.org

Universal cell embedding provides a foundation model for cell biology - Nature

The universal cell embedding foundation model learns to capture the organization and variation of cells by training on 36 million cells from hundreds of experiments, dozens of tissues and eight specie...

nature.com

Is Life Just Different? | Quanta Magazine

The idea of ‘biological agency’ — that life devises its own goals and behaves accordingly — complicates our understanding of what it means to be alive. But does it serve a scientific purpose?

quantamagazine.org

Biomni: A General-Purpose Biomedical AI Agent

Biomedical research underpins progress in our understanding of human health and disease, drug discovery, and clinical care. However, with the growth of complex lab experiments, large datasets, many an...

biorxiv.org

FDA Approves First Gene Therapy for Young Children with Sickle Cell Disease

The U.S. Food and Drug Administration today issued a supplemental approval for Casgevy (exagamglogene autotemcel) for patients aged 2 years and older with either sickle cell disease (SCD) with recurre...

fda.gov

The Genes That Could Cancel Out a Fatal Diagnosis

The key to treating genetic disease might be hidden in other “modifier” genes.

theatlantic.com

Synthetic biology may finally be ready to solve life's biggest mystery

What makes something alive? We simply don't know, but synthetic biologists are a step closer to providing an answer thanks to SpudCell, the most sophisticated attempt at creating an artificial life fo...

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Advancing regulatory variant effect prediction with AlphaGenome - Nature

AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

nature.com

For the First Time, a Cell Built From Scratch Grows and Divides | Quanta Magazine

Scientists built a synthetic cell that combines more lifelike properties than ever before — proof of concept that it’s possible to bring nonliving materials to life, or something close to it, in the l...

quantamagazine.org

Biotic | SpudCell

SpudCell and Biotic — announcement and media factsheet.

biotic.org

This Cell Feeds, Grows and Reproduces. And It’s Manmade.

From chemical building blocks, scientists have created synthetic cells that have most of the hallmarks of life.

nytimes.com

Scientists Made a Cell With Most of the Hallmarks of Life. Here’s What to Know.

nytimes.com

Science Magazine (@ScienceMagazine) on X

For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a c...

x.com

Structural motif search across the protein-universe with Folddisco

Detecting similar protein structural motifs, functionally crucial short 3D patterns, in large structure collections is computationally prohibitive. Therefore, we developed Folddisco, which overcomes t...

biorxiv.org

Bacteria can learn and form memories without a brain

​Scientists have shown that bacteria can learn from past experiences, store memories across generations and adapt their behavior to changing environments.

the-microbiologist.com

Should every baby’s DNA be sequenced?

The genomic generation is on its way

economist.com

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation

Poly(ethylene terephthalate) (PET) is one of the most widely used plastics in food and textile applications, yet post-consumer PET waste persists and …

sciencedirect.com