Australasian Epigenetic Alliance (AEpiA)

@aepia.bsky.social

Uniting epigenetics researchers across Australasia https://www.aepia.org.au/ DMs not monitored, email aepia@asnevents.net.au

Chen et al 2026. Genome-wide rotational and translational phasing of nucleosomes with human transcription factors www.cell.com/molecular-ce... ▶️ In vivo nucleosome phasing measured on the same TF-bound DNA molecule ▶️ Phasing around CTCF sites is DNA encoded ▶️ FoxA and NFIA phase adjacent nucleosomes

How transcription factors (TFs) and their binding sites organize and engage nucleosomes at natural genomic locations remains poorly understood. Here, we develop Benzonase-seq to measure the rotational phasing of nucleosomes in human cells and enhance chromatin immunoprecipitation (ChIP)-exo (v6) to measure rotational phasing on the same DNA molecule bound by a TF. Unbound CTCF sites were found to be rotationally accessible on nucleosomes, and this rotational accessibility is encoded by classical dinucleotide periodicities. CTCF binding results in nucleosome displacement to adjacent DNA phasing sequences. Upon examining 40 TF classes, unbound sites were found to be phased either inward or outward or to lack phasing. In all examined cases, TF binding (e.g., NFIA and FoxA) results in adjacent rotational and translational phasing, which is not dinucleotide encoded. Benzonase-seq also more robustly maps nucleosome and subnucleosome positions in hard-to-map CpG islands. These findings provide a clearer view of how TFs engage and position nucleosomes to shape the natural chromatin landscape.

𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗻𝗼𝘄 𝗼𝗽𝗲𝗻 𝗳𝗼𝗿 𝘁𝗵𝗲: 𝗔𝗘𝗽𝗶𝗔 𝗦𝘂𝘀𝗮𝗻 𝗖𝗹𝗮𝗿𝗸 𝗔𝘄𝗮𝗿𝗱 𝗳𝗼𝗿 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗘𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝗰𝗲 @aepia.bsky.social is excited to open applications for the Susan Clark Award for Research Excellence, recognising outstanding contributions in epigenetics research, leadership, and advocacy.

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1/n 💙 🤍 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 𝐢𝐬 𝐛𝐨𝐭𝐡 𝐋𝐮𝐧𝐠 𝐂𝐚𝐧𝐜𝐞𝐫 𝐀𝐰𝐚𝐫𝐞𝐧𝐞𝐬𝐬 𝐌𝐨𝐧𝐭𝐡 𝐚𝐧𝐝 𝐌𝐨𝐯𝐞𝐦𝐛𝐞𝐫, 𝐚 𝐭𝐢𝐦𝐞 𝐭𝐨 𝐬𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭 𝐦𝐞𝐧’𝐬 𝐡𝐞𝐚𝐥𝐭𝐡, in both of which Epigenetics plays an important role 🧬 𝐓𝐨𝐝𝐚𝐲 𝐰𝐞’𝐫𝐞 𝐡𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐢𝐧𝐠 𝐞𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐢𝐧 𝐥𝐮𝐧𝐠 𝐜𝐚𝐧𝐜𝐞𝐫 by the Burr Laboratory www.burrlab.com/ #AEpiA #Epigenetics #LungCancer

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✨ 1 week until abstract deadline! ✨ 𝐓𝐡𝐞 𝐢𝐧𝐚𝐮𝐠𝐮𝐫𝐚𝐥 𝐀𝐄𝐩𝐢𝐀 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 is happening 𝐓𝐡𝐮𝐫𝐬𝐝𝐚𝐲 𝟒𝐭𝐡 𝐃𝐞𝐜𝐞𝐦𝐛𝐞𝐫. This event brings together researchers from across Australasia to share science, career insights, and community connection. Registration is FREE, but essential. #AEpiA #EMCRsymposium

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I had a fantastic few days at the 🧬 𝗔𝘂𝘀𝘁𝗿𝗮𝗹𝗶𝗮𝗻 𝗖𝗲𝗹𝗹 𝗖𝘆𝗰𝗹𝗲, 𝗗𝗡𝗔 𝗥𝗲𝗽𝗮𝗶𝗿 𝗮𝗻𝗱 𝗧𝗲𝗹𝗼𝗺𝗲𝗿𝗲 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 at the Melbourne Museum, which I attended with many colleagues from @cmri.bsky.social It was an excellent meeting filled with inspiring science and engaging talks. Looking forward to the next one in 2027!

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📢 𝐄𝐱𝐜𝐢𝐭𝐢𝐧𝐠 𝐔𝐩𝐝𝐚𝐭𝐞𝐬 𝐟𝐨𝐫 𝐭𝐡𝐞 Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! 🎓 We’re thrilled to announce that 𝐓𝐡𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲 𝐨𝐟 𝐌𝐞𝐥𝐛𝐨𝐮𝐫𝐧𝐞 is now confirmed as an in person-node for this event! To join our Melbourne community in person register via the event website: aepia.org.au/emcr-symposium

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🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐃𝐡𝐚𝐧𝐲𝐚 𝐒𝐨𝐨𝐫𝐚𝐣 We’re delighted to feature Dr Dhanya Sooraj, one of our career development panellists for the upcoming 𝐀𝐄𝐩𝐢𝐀 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! Dhanya brings a wealth of experience in advanced genomics and epigenetics. #AEpiA #EMCRsymposium

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🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐋𝐮𝐤𝐞 𝐈𝐬𝐛𝐞𝐥 🌟 We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! aepia.org.au/emcr-symposium

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🌟 𝐌𝐞𝐞𝐭 𝐨𝐮𝐫 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭: 𝐀⁄𝐏𝐫𝐨𝐟 𝐏𝐡𝐢𝐥𝐥𝐢𝐩𝐩𝐚 𝐓𝐚𝐛𝐞𝐫𝐥𝐚𝐲 🌟 We’re thrilled to introduce @piptaberlay.bsky.social, Principal Research Fellow and Cancer and Genomics Theme Lead at @menzies-research.bsky.social, @utas.edu.au, and incoming Chair of @aepia.bsky.social

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