Adriana Marton
@aestivation-med.bsky.social
About energy and water conservation - an ancient survival program that may still be active in humans, and could help us understand hypertension, ageing and chronic disease
Why do SGLT2 inhibitors protect heart and kidneys? 🫀 In @natrevneph.nature.com, we proposed that the body activates an aestivation-like program, shifting energy metabolism to conserve water and prevent glycosuria-driven dehydration. #aestivation still active in humans? #MedSky rdcu.be/75K79DdbK1Aa
Over 350 million years ago, animals leaving the water had to avoid drying out. They changed their metabolism to save body water 🐸 #aestivation We still carry that ancient program. We study how this link between water conservation and energy metabolism may shape aging and disease 💧 #SciSky