📖 The September issue is now online! It includes: 🔷Research on achalasia and esophageal malignancies 🔷A systematic review of interventions for increasing #CRC screening uptake 🔷A strategy for enhancing the therapeutic potential of probiotics in #IBD 🔗https://ow.ly/x92b50ZC1IR

💚 Ever wonder what delayed stomach emptying feels like? August is #GastroparesisAwarenessMonth 💚 👩‍⚕️ Gastroparesis can happen in anyone, and symptoms can come and go. Help us connect the patients and caregivers affected, and explore patient resources at https://ow.ly/g6cv50ZBUPY

📸 Gastro Curbside Consult presents an unexplained coexisting injury of the liver, pancreas, and brain. Can you determine the diagnosis? https://ow.ly/Ow9g50ZAyo3

1/ 💬 A new three-part commentary series in #Gastroenterology examines some of the most pressing questions in liver transplantation today. ⬇️ Join the conversation as experts share perspectives on where the field is now and where it may be headed next. #Hepatology

If you read "A Randomized Double-Blind, Placebo-Controlled Dose–Response Study to Assess the Gluten Threshold Dose in Celiac Disease," check out the corresponding editorial discussing the use of the Interleukin-2 test. 🔗 https://ow.ly/ykW450ZybIr

In >11,000 ERCP patients, single-dose rectal NSAIDs were not associated with adverse renal outcomes, even among older adults and those with CKD. Read more at: 🔗 https://ow.ly/kMpt50ZybLr

🫀 INTERBLEED international prospective cohort study examines cardiovascular outcomes following major gastrointestinal bleeding in patients with pre-existing cardiovascular disease. Read more at https://ow.ly/lkCk50Zy9mt

👧 In children with acute severe #ulcerativecolitis, intestinal ultrasound helped identify patients unlikely to respond to first-line therapy and at higher risk for colectomy. 🔗 https://ow.ly/BR6m50ZwBkl #PedsGI

🔎 How should T1b esophageal adenocarcinoma in a 64-year-old patient be managed? Gastro Grand Rounds article examines treatment options and the role of multidisciplinary care: https://ow.ly/1pyw50Zwmrq

🧬 A DNA/RNA test on bile duct samples detects cancer more accurately than standard methods, especially in high-risk patients, and identifies gene changes that can guide personalized treatment. 🔗 https://ow.ly/psVq50Zrr9r

Study finds reduced intestinal epithelial GPX4 expression as a predictor of #CrohnsDisease recurrence after ileocolonic resection. GPX4 improved risk prediction beyond clinical factors and emerged as a potential therapeutic target, with selenium restoring GPX4 and reducing enteritis in mice.

🌟 153 gluten and placebo challenges from 1000mg to 1mg were given to people with #CeliacDisease. Study found that an eliciting dose did not result in an immune response in 95% (ED5) of participants. 🔗 Read more at https://ow.ly/TlxT50ZrqI2

🧬 Review highlights how polygenic risk scores and key variants such as PNPLA3, TM6SF2, and HSD17B13 may improve risk stratification for fibrosis progression and cirrhosis in #MASLD and #ALD. 🔗 https://ow.ly/Bet650ZrqtZ

💡 Study finds f-Hb–guided surveillance after polypectomy optimizes colonoscopy use, lowers #CRC risk, and outperforms USMSTF and ESGE guidelines in FIT-based screening. Learn more at https://ow.ly/Ws4850ZrpBw

📣 The August issue of #Gastroenterology is now available online! Essential reading includes: 🔹 An assessment of gluten threshold in #CeliacDisease 🔹 A study on intestinal ultrasound and severe pediatric #IBD 🔹 Research on GI bleeding and cardiovascular outcomes 🔗 https://ow.ly/lqO850ZrpjC

Study finds that STING-deficient CAR-T cells + diABZI boost antitumor activity, increase CAR-T persistence, and improve tumor control in pancreatic cancer models, highlighting a potential new strategy for solid tumors. 🔗 https://ow.ly/JVzg50Zq3PM

💡Recordings of motion-guided biofeedback using abdominothoracic wall reduced rumination, providing the first simple, mechanism-based behavioral therapy directly translated from rumination physiology. 👉 Learn more at https://ow.ly/th5P50ZmZsu

👶 Early life stress disrupts the gut-brain axis; reshapes enteric circuits, motility, and visceral pain via sex hormones and sympathetics, and link these mechanisms to #DGBI risk in human cohorts. 🔗 https://ow.ly/o5N550ZmZxa

Nationwide cohort of 16,000 Swedish patients with isolated ulcerative proctitis showed no increased risk of rectal cancer or high-grade dysplasia compared with the general population over the course of 10 years. 🔗 https://ow.ly/P6Uq50ZmZm6 #UlcerativeProctitis #ColorectalCancer

🩺 With #MASLD affecting nearly 1 in 3 U.S. adults, the AGA's updated Clinical Care Pathway incorporates the latest evidence on disease nomenclature, risk stratification, diagnosis, and treatment, including newly approved therapies. 🔗 https://ow.ly/5Gfz50ZkL4y

🧬 Commentary highlights how immunotherapy continues to transform care across metastatic, adjuvant, and neoadjuvant settings for patients with dMMR/MSI-H #colorectalcancer. 🔗 https://ow.ly/h61w50ZkKuv

While incidence has stabilized, prevalence continues to grow. An aging #IBD population will increasingly strain healthcare systems aiming to provide affordable, accessible, high-quality care. 🔗 https://ow.ly/mvj650ZkJS5

Defecation urgency in #IBS reflects distinct gut–brain mechanisms. Real-life and barostat-induced urgency show different symptom profiles and brain correlates. Click the link to read more: https://ow.ly/ppNp50ZiqUU

Comparison of two #dose-intensification regimens in patients with #CrohnsDisease experiencing #LOR to #ustekinumab showed comparable low recapture of remission after 48 weeks. 🔗 https://ow.ly/1liv50ZiqS9

Study finds ganglioside-mediated neural-acinar crosstalk facilitates pancreatic carcinogenesis via metaplastic niche remodeling. Read more at https://ow.ly/SzqW50ZiqJe

Potential celiac disease offers a unique window into early autoimmunity, before intestinal damage occurs. Only some individuals progress to celiac disease, highlighting opportunities for risk stratification and prevention. 🔗 https://ow.ly/xA7i50ZhmTK #CeliacDisease #Autoimmunity

💡 Immediate direct endoscopic necrosectomy achieved faster clinical success than the step-up approach with comparable safety. Despite requiring more procedures, it may be a reasonable option in selected patients. Read more at https://ow.ly/Z67v50Zghsv

📣 The July issue of #Gastroenterology is now online! Essential reading includes: 🔹New research on the microbiome and postoperative #CrohnsDisease recurrence 🔹An RCT of timing for pancreatic necrosectomy 🔹A brief report forecasting #IBD incidence around the globe 🔗 https://ow.ly/x7Rc50Zfiht

🌟 For people with diabetes who suffer from severe stomach emptying problems, a new gentle endoscopic treatment called G-POEM eased symptoms and improved stomach function significantly. Read the full study here: https://ow.ly/IxEE50ZbTO1

Gastro has received a 2025 Impact Factor of 29.7! On behalf of Editors-in-Chief Paul Moayyedi & David Weinberg, thank you to our editors, authors, reviewers & readers for your continued support. https://ow.ly/c9co50ZenCT American Gastroenterological Association (AGA)

Just released: AGA journals receive new Impact Factor scores

The American Gastroenterological Association (AGA) is the trusted voice of the GI community. AGA publishes top-tier journals, guidelines and patient education ...

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