Effects of nutritional interventions on biomarkers of cellular senescence in humans: A systematic review

Cellular senescence is a fundamental mechanism of ageing, characterised by stable cell cycle arrest and the acquisition of a pro-inflammatory secretor…

sciencedirect.com

mdpi.com

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Pasta is a transcriptomic aging clock built on an age-shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platfor....

advanced.onlinelibrary.wiley.com

Embracing non-linearity in human ageing - Nature Reviews Genetics

Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such e...

nature.com

Hu et al. 2026

Read the full text of Leveraging mRNA-based transcriptional signatures and machine learning for healthy aging drug discovery

ephyrapublishing.com

Primate Aging, Health, and Social Relationships

The global rise in the number of elderly individuals in the human population, coupled with an epidemic of loneliness, emphasizes the need to understand the interaction between aging and sociality. Nat...

annualreviews.org

I've spent my career studying ageing. Here are the 7 ways I slow my biological clock | BBC Science Focus Magazine

What should we be doing to stay healthy for longer? Meet the scientist who’s testing cutting-edge ageing research on his own body.

sciencefocus.com

JCI - Functional, molecular, and digital measurements of biological age

jci.org

Rejuvenation Potential of Developmental Genes Downregulated in Aging

Byungkuk Min, Juhyeon Nam, Minseo Choi, Junyoung Hong, Areum Baek, Janghwan Kim. IJSC -0001;0:. https://doi.org/10.15283/ijsc25144

ijstemcell.com

mdpi.com

Cryptic transcription in aging

molecular biology, epigenetics and stem cells research

cell.com

mdpi.com

Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

science.org

Signatures of aging and disease in a single organelle

Changes in lysosomal metabolites are associated with both aging organs and lysosomal storage diseases

science.org

The hallmarks of protein and amino acid restriction in aging and longevity

Dietary protein is a key regulator of health and longevity across species, and restriction of proteins or other specific amino acids has emerged as a potential strategy to promote healthy aging. Here,...

cell.com

Biological Versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response

Epigenetic clocks accurately measure biological age, but how reliable are they in practice? This study reveals a critical divergence: while clocks are highly consistent across laboratory replicates (...

onlinelibrary.wiley.com

How epigenetic clocks tick: unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging - npj Aging

npj Aging - How epigenetic clocks tick: unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging

nature.com

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...

science.org

The anti-aging infusion that went wrong: Unlicensed ‘doctor’ faces charges after woman’s death

A New York man accused of posing as a doctor admitted he 'made a very big mistake' after a 27-year-old woman died during an anti-aging NAD+ infusion at his Bronx wellness clinic; He faces charges as a...

ynetnews.com

The blood proteome predicts the impact of circulating factors on age-related mitochondrial health - npj Aging

npj Aging - The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

nature.com

Senotypes define the diverse landscape of senescent cells - Nature Aging

This Perspective proposes a senotype framework for classifying senescent cells by their origins, molecular features and effects, which will foster comparison of diverse senescent states, including tho...

nature.com

Genomic, epigenomic and transcriptomic regulation of cellular senescence - Nature Reviews Genetics

Senescence — a complex, dynamic and heterogeneous stress-responsive cell state — shapes ageing biology and tissue homeostasis. This Review examines the molecular regulation of senescence initiation, m...

nature.com

Frontiers | Mitochondrial transcription factor A: linking mtDNA maintenance, mitochondrial stress responses, and inflammaging

Mitochondrial transcription factor A (TFAM) is a nuclear-encoded mitochondrial protein that directly binds mitochondrial DNA (mtDNA) and contributes to mitoc...

frontiersin.org

Mitochondrial metabolism and epigenetic crosstalk drive SASP - Nature

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, unders...

nature.com

Gut microbiome signatures associate with DNA methylation-based biological aging - Scientific Reports

Scientific Reports - Gut microbiome signatures associate with DNA methylation-based biological aging

nature.com

<fc>GW9508</fc>‐Induced Activation of <fc>GPR40</fc> in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2-MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to countera...

onlinelibrary.wiley.com

Construction and Validation of Plasma Protein‐Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles

We developed plasma protein-based musculoskeletal aging clocks, MSKAge and MSKAgeMort, using UK Biobank proteomic data, and showed that MSKAgeAccel and MSKAgeMortAccel (in particular) predicted morta...

onlinelibrary.wiley.com

Metabolic Signatures of Aging and Gametogenesis in <fc><fi>Hydra oligactis</fi></fc>

Hydra oligactis undergoes cold-induced sexual differentiation and aging, culminating in death. GC–MS-based metabolite profiling revealed signatures of gametogenesis, for example, polyamine accumulati...

onlinelibrary.wiley.com

FUBL-3/FUBP1 mediates mitochondrial stress–induced chromatin remodeling and longevity

A conserved mitochondrial-nuclear effector, FUBL-3/FUBP1, remodels chromatin to promote stress resilience and longevity.

science.org

Genome-wide multi-layered epigenomic profiling across human aging

Aging is characterized by highly reproducible alterations across multiple layers of the epigenetic landscape, including DNA methylation, chromatin accessibility, and histone modifications. However, it...

biorxiv.org