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Andrew Monteith

@ajmonteith.bsky.social

Exploring the delicate balance between metabolic and inflammatory processes in disease. @UTKmicrobiology. Views my own.

5 Posts114 Follower 144 Folgt

Andrew Monteith @ajmonteith.bsky.social · 4w ago

Excited to share our new paper in @cellpressblue.bsky.social. We show that #lupus shifts neutrophils away from bactericidal NETosis and toward a less protective vital NET release. Huge thanks to Eden, our trainees, and collaborators! @utkmicrobiology.bsky.social www.cell.com/cell-press-b...

TLR7/9 and type I interferon signaling reprogram neutrophil NET responses and impair antibacterial defense in systemic lupus erythematosus

TenBarge et al. show that lupus-associated TLR7/9 and type I interferon signaling reprogram neutrophil NET responses during Staphylococcus aureus infection. This shifts neutrophils away from LDHB-depe...

cell.com

Carolyn Ibberson @cbibberson.bsky.social · last yr.

Excited to have our new mini review on Microbiome Metabolism out today in I&I as part of the @asm.org New Voices in Microbiology collection! Check it out! 🧫🧪 journals.asm.org/doi/10.1128/...

Infections as ecosystems: community metabolic interactions in microbial pathogenesis | Infection and Immunity

Microbial communities are present on nearly every surface of the human body. These microbiomes exist as dynamic ecosystems that are influenced by heterogeneous nutritional and chemical landscapes, the...

journals.asm.org

Francis Alonzo @francisalonzo12.bsky.social · last yr.

Happy to share Iván’s first-author pub from the lab! www.cell.com/cell-reports...

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress

Acosta et al. find that ADP-ribosylation of the lipoic acid carrier protein GcvH-L promotes Staphylococcus aureus resistance to oxidative burst and facilitates infection. ADP-ribosylation leads to a s...

cell.com

Andrew Monteith @ajmonteith.bsky.social · last yr.

Just out in Infection and Immunity! Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs. Read it here: journals.asm.org/doi/full/10.... #neutrophils #immunometabolism #NETosis #hostpathogen

Live fast, die young: neutrophils streamline their metabolism to maximize inflammation | Infection and Immunity

Cell metabolism plays a key role in shaping immune cell differentiation and function, with each immune cell subset depending on distinct metabolic pathways. While there have been extensive studies and...

journals.asm.org

Andrew Monteith @ajmonteith.bsky.social · last yr.

The debut paper from the lab is live! Check out the amazing work by @ashleydwise.bsky.social and collaborators discovering that mitochondria are not just the 'powerhouse of the cell' but adapted by neutrophils to sense bacterial persistence and trigger NETosis. www.cell.com/cell-host-mi...

Mitochondria sense bacterial lactate and drive release of neutrophil extracellular traps

Historically, neutrophil mitochondria were overlooked as they do not contribute to energy homeostasis. Wise et al. reveal that neutrophil mitochondria can sense bacterial persistence in the phagosome ...

cell.com

Conlon Lab @bconlon.bsky.social · 2y ago

Delighted to share our new study. A collaboration with the Thurlow lab. Antibiotic resistance rapidly emerges and thrives in diabetic mice. A worrying coming together of two major and growing health problems worldwide www.science.org/doi/10.1126/...

Diabetes potentiates the emergence and expansion of antibiotic resistance

Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.

science.org