Alberto Marin
@albertomarin.bsky.social
Postdoctoral fellow. Labs of Taekjip Ha and Ralph Scully, Harvard Medical School. DNA repair in time and space. Biophysics of genome integrity.
Excited to share our latest pre-print: www.biorxiv.org/content/10.6... where we built a biophysical polymer model of the mammalian homology search. This work was led by Tylar Matsuo, an outstanding post-bac student in the Ha lab that I have had the pleasure to mentor. Here is what we found. 1/n
Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA. Learn more in a new #SciencePerspective: https://scim.ag/3XKbhb6
A tale of two forms of cohesin in DNA repair
Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA
scim.ag
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
science.org
1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! www.biorxiv.org/content/10.1...
Cohesin drives chromatin scanning during the RAD51-mediated homology search.
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce de novo formation of chromatin loops, with the break positioned at the loop b...
biorxiv.org