Alberto Mazzoni @Sant'Anna Pisa
@albmazz.bsky.social
Computational Neuroengineer
Predicting #Alzheimer's onset from EEG recordings thanks to a novel perspective on #DigitalTwins. A novel, non invasive, low cost prognostic method validated on 100s of patients thanks to the collaboration with Alzheimer Center Amsterdam. www.nature.com/articles/s41...
Predicting Alzheimer progression using EEG-based digital twins - npj Digital Medicine
npj Digital Medicine - Predicting Alzheimer progression using EEG-based digital twins
nature.com
This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.
Interested in modeling #Parkinson’s therapies? Check out our model of the effects of Deep Brain Stimulation on basal ganglia dynamics. Just out in PLoS Comp Biol. journals.plos.org/ploscompbiol...
In silico model of basal ganglia deep brain stimulation in Parkinson’s disease captures range of effective parameters for pathological beta power suppression
Author summary Deep brain stimulation (DBS) is an effective treatment for alleviating symptoms of Parkinson’s disease (PD), but its underlying mechanism is unclear. Motor symptoms of PD are linked to ...
journals.plos.org
Neuromorphic architectures do not simply learn to properly decode sensory stimuli: they do it in an energy efficient way. My latest work out in @natcomms.nature.com www.nature.com/articles/s41...
Bioinspired spiking architecture enables energy constrained touch encoding - Nature Communications
Current tactile sensing solutions face challenges in excessive wiring, high energy demands of AI computing, and limitations in scalability and parallel processing. Here, the authors present a neuromor...
nature.com
Our personalized cortical models can diagnose #dementia early using non-invasive EEG/MEG. They generalize across data from different centers and recording modalities, boosting real-world reliability. #Neurotech #digital_twins www.nature.com/articles/s43...
Digital twins support cross-modal and cross-centric classification of mild cognitive impairment - Communications Medicine
Amato et al. evaluate whether brain digital twins can be utilized to derive robust dementia biomarkers. Biomarkers derived from digital twin outperform standard MEG and EEG metrics in diagnosing patho...
nature.com
aDBS revealed long-term drifts and sudden changes in #Parkinsons subthalamic activity. We propose a deep learning framework to predict them before they lead to clinical consequences www.nature.com/articles/s41...
Transformer-based long-term predictor of subthalamic beta activity in Parkinson’s disease - npj Parkinson's Disease
npj Parkinson's Disease - Transformer-based long-term predictor of subthalamic beta activity in Parkinson’s disease
nature.com
Into population dynamics? Coming to #CNS2025 but not quite ready to head home? Come join us! at the Symposium on "Neural Population Dynamics and Latent Representations"! 🧠 📆 July 10th 📍 Scuola Superiore Sant’Anna, Pisa (and online) 👉 Free registration: neurobridge-tne.github.io #compneuro
Novel work from the Computational Neuroengineering Laboratory at Sant'Anna (Pisa) From computational models to clinical applications: a digital twin of #Alzheimers enables prediction of individual patients' dementia evolution from non-invasive EEH recordings link.springer.com/article/10.1...
Digital twins and non-invasive recordings enable early diagnosis of Alzheimer’s disease - Alzheimer's Research & Therapy
Background The diagnosis of Alzheimer’s disease (AD) in its preclinical stages, such as subjective cognitive decline (SCD), is crucial for a timely management of the condition. However, current early ...
link.springer.com
Just over half of the children born in 2020 will face unprecedented exposure to heatwaves over their lifetime — even under a conservative projection for how climate change will unfold over the next 75 years https://go.nature.com/3YzbUFn
How climate change will burden our children: data reveal a lifetime of extreme heat
Young people will be exposed to a number of heatwaves that no one would have experienced in pre-industrial times.
go.nature.com
Our novel network model of early stages of #Alzheimer's identifies a phase transition in neurodegeneration parameters that could support early diagnosis based only on EEG recordings alzres.biomedcentral.com/articles/10....
Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration - Alzheimer's Research & Therapy
Cognitive decline is a condition affecting almost one sixth of the elder population and is widely regarded as one of the first manifestations of Alzheimer’s disease. Despite the extensive body of know...
alzres.biomedcentral.com
The Palestinian co-director of Oscar-winning film "No Other Land" Hamdan Ballal was beaten up by Israeli settlers in the occupied West Bank and taken away by Israeli soldiers, his colleagues and eyewitnesses said.
Oscar-winning Palestinian director of ‘No Other Land’ assaulted by Israeli settlers in the West Bank | CNN
The Palestinian co-director of Oscar-winning film “No Other Land” Hamdan Ballal was beaten up by Israeli settlers in the occupied West Bank and taken away by Israeli soldiers, his colleagues and eyewi...
cnn.com
Another piece of the puzzle of the genetic aetiology of dystonia falls into place: how the genetic profile affects spectral components of globus pallidus activity. onlinelibrary.wiley.com/doi/full/10....
Genetic Etiology Influences the Low‐Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia
Background Elevated low-frequency activity (4–12 Hz) within the globus pallidus internus (GPi) has been consistently associated with dystonia. However, the impacts of the genetic etiology of dystoni...
onlinelibrary.wiley.com
Interested in #dystonia? Wondering how so many different genes can lead to this pathology? We might have found some answers analysing neural recordings from basal ganglia. Check our latest paper just out on Annals of Neurology: onlinelibrary.wiley.com/doi/full/10....
Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes
Objective Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functio...
onlinelibrary.wiley.com
Article from @science.org re: today's freeze on #NIH study sections, Council, comms, hiring, travel www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
science.org
A few days left for Tutorials and Workshops proposals submission for the 2025 meeting of the Organization for Computational Neuroscience. And this year the congress takes place in the most beautiful city of the world - you really can't miss it! www.cnsorg.org/cns-2025
CNS 2025
cnsorg.org
First post on @bsky.app to announce my first paper published @science.org! How much do we know about how the cortex encodes the same movement when it is performed in arbitrarily different contexts? Find out here: www.science.org/doi/10.1126/...
Neuroethology of natural actions in freely moving monkeys
The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving ...
science.org