Could a cross-organ warning system be a defining factor in how the brain combats arthropod-borne neurotropic viruses?

Thank you for the highlight! @rockefeller.edu

The Rockefeller University @rockefeller.edu · 2mo ago

Alexander Lercher of Rockefeller's Rice lab studies how fighting off one virus changes the way the immune system responds to a totally unrelated one. His work is uncovering immune pathways that let our bodies adapt to viral threats over time. 🔗: https://bit.ly/43GfYWw

The main function of the TCA cycle is to feed electrons into the respiratory chain. ..wait, what!? It also clears excess citrate, because otherwise you get severe kidney damage? Great example that textbooks aren’t always the full story by Abby, @juliabrunner.bsky.social and @lydiafinley.bsky.social

Julia S. Brunner@juliabrunner.bsky.social · 5mo ago

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

Julia’s paper identifying Aspartate as a determinant cell-state specific engagement of the Malate-Aspartate-Shuttle is now out @cp-molcell.bsky.social!

Julia S. Brunner@juliabrunner.bsky.social · 5mo ago

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

A lncRNA packaged in exosomes induces epigenetic reprogramming to alter future immune responses - pretty cool way of "͏𝚒͏𝚗͏𝚗͏𝚊͏𝚝͏𝚎 ͏𝚒͏𝚖͏𝚖͏𝚞͏𝚗͏𝚎 ͏𝚖͏𝚎͏𝚖͏𝚘͏𝚛͏𝚢 ͏𝚝͏𝚛͏𝚊͏𝚗͏𝚜͏𝚖͏𝚒͏𝚜͏𝚜͏𝚒͏𝚘͏𝚗" @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...

A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

Yu et al. discover that TRCR1, a tuberculosis resister-derived exosomal lncRNA, induces trained immunity via CLOCK-mediated epigenetic reprogramming. They show that mycobacterial protein MPT53 prompts...

cell.com

Thank you very much #ASciNA and @fwf-at.bsky.social for the ASciNA Young Investigator Award! Link to publication @cp-immunity.bsky.social : www.cell.com/immunity/abs...

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease

The therapeutic potential of antigen-independent innate immune memory (IIM) is of particular relevance in the context of respiratory viruses with pandemic potential. Lercher et al. find that antiviral...

cell.com

Österreichischer Wissenschaftsfonds FWF@fwf-at.bsky.social · 10mo ago

Auszeichnung exzellenter österreichischer Wissenschaftler:innen in den USA: 3 Forschende erhalten heuer #ASciNA Awards für während ihrer Forschungsaufenthalte entstandene Publikationen: Wir gratulieren Caroline Moosmüller, Alexander Lercher u. Gabriele Wadlig! 👏 #BMFWF www.fwf.ac.at/aktuelles/de...

Innate immune memory is wild 🧠 Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses! Full interview: buff.ly/5TKEJ9o #CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo

Member Highlight: Alexander Lercher on Innate Immune Memory and Real-World Microbe Responses - Biweekly newsletter of the International Cytokine & Interferon Society

My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context...

signals.cytokinesociety.org

Thank you for the member highlight @cytokinesociety.bsky.social and see you all in Seattle for Cytokines 2025! signals.cytokinesociety.org/2025/09/28/m...

Member Highlight: Alexander Lercher on Innate Immune Memory and Real-World Microbe Responses - Biweekly newsletter of the International Cytokine & Interferon Society

My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context of real-world microbe exposure. Out from the lab, my biggest hobby for the past years has been to explore the

signals.cytokinesociety.org

Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award! Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!

International Cytokine & Interferon Society (ICIS)@cytokinesociety.bsky.social · last yr.

The International Cytokine & Interferon Society congratulates the winners of the 2025 Sidney & Joan Pestka Graduate and Post-Graduate Awards, the ICIS-Christina Fleischmann Award and the ICIS-Amanda Proudfoot Award. Read more at signals.cytokinesociety.org/2025/07/14/2...

Location, infection history, antigen persistence shape the phenotype of tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases. High/low antigen immunogenicity may add another layer... @cp-immunity.bsky.social tinyurl.com/49dkc3j7

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential! Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs tinyurl.com/5yahn47t tinyurl.com/4n4btxap

Great Spotlight by @virusesimmunity.bsky.social and #SashaTabachnikova on our recent publication in #Immunity, where we studied antiviral innate immune memory in alveolar macrophages in the context of respiratory viral infections! www.cell.com/trends/immun...

SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu

Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resid...

cell.com

If you are rather an auditory person than a reading person – TWIV discussed our recent paper on antiviral innate immune memory in sequential respiratory viral infections. Paper review starts at 37:00, more general discussion and broader implications at 1:10:00. open.spotify.com/episode/777w...

TWiV 1165: What doesn't kill us primes our macrophages

This Week in Virology · Episode

open.spotify.com

How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on.. Paper at Immunity: www.sciencedirect.com/science/arti...

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases? shorturl.at/SZ1Ww #CellStemCell

Curious how commonly circulating respiratory viruses affect respective disease? Past SARS2 infection ameliorates disease caused by secondary influenza virus via innate immune memory in airway-resident macrophages. @biorxivpreprint.bsky.social link below. www.biorxiv.org/content/10.1...