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Alex McCarthy

@alex-mccarthy.bsky.social

Associate Professor at Imperial College London. Inhibitory Receptors and Bacterial Infection Biology. https://dralexmccarthy.wixsite.com/alexmccarthylab

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Alex McCarthy@alex-mccarthy.bsky.social · last mo.

New paper 📄 out in @embomolmed.org: We show that the Slr protein of S. pyogenes is a target of protective antibodies and present evidence that it is selectively expressed in vivo. Link: pubmed.ncbi.nlm.nih.gov/42298213/

The Slr protein of Streptococcus pyogenes is selectively expressed in vivo and is a target for protective antibodies - PubMed

Vaccine candidates are typically identified through characterization of microbial surface antigens expressed under laboratory conditions. Here, we studied the major human pathogen Streptococcus pyogen...

pubmed.ncbi.nlm.nih.gov

Alex McCarthy@alex-mccarthy.bsky.social · last mo.

New paper 📄 out in @natcomms.nature.com: We show that bacteria can target inhibitory receptors expressed on neutrophils to actively subvert antibody-driven immune responses, using LILRB3 and Group B Streptococcus as a study system. Link: www.nature.com/articles/s41....

Bacterial targeting of the neutrophil inhibitory receptor LILRB3 to evade antibody immunity - Nature Communications

Antibody-mediated immunity is essential to protect hosts from bacterial pathogens. Here, the authors show that Streptococcus agalactiae targets inhibitory LILRB3 receptor on neutrophils to supress ant...

nature.com