Epilepsy imaging-genetics paper is fresh off the press!
Boris Bernhardt@borismontreal.bsky.social · 12mo agoNews from ENIGMA-Epilepsy! 🧠 Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients. Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge. Read more 👉 doi.org/10.1093/brai...
Our open-source multimodal precision MRI dataset is officially out! 🧲🧠🧲 www.nature.com/articles/s41... osf.io/mhq3f/ @borismontreal.bsky.social @jroyer.bsky.social @themindwanders.bsky.social @jordandekraker.bsky.social
Multimodal precision MRI of the individual human brain at ultra-high fields - Scientific Data
Scientific Data - Multimodal precision MRI of the individual human brain at ultra-high fields
nature.com
Out in @natureneuro.bsky.social today 🥂 Cytoarchitecture, wiring and signal flow of the human default mode network Combining 3D histology, 7T MRI, and connectomics to explore DMN structure-function associations Led by Casey Paquola, @themindwanders.bsky.social & a terrific team of colleagues 🙏
The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow - Nature Neuroscience
The default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to input from the sensory cortex and a core relatively insulated from environmental input, and it uniquely balances its output across sensory hierarchies.
nature.com
New preprint (first of my PhD) | Associations between epilepsy-related polygenic risk and brain structure in childhood 🧬🧠⚡️ Elevated PRS for TLE-HS is linked to cortical thinning in healthy children—mirroring atrophy patterns observed in epilepsy case-control studies bit.ly/imaging-gene...
in press 💫 Temporal Lobe Epilepsy Perturbs the Brain‐Wide Excitation‐Inhibition Balance: Associations w/ Microcircuits, Clinical Parameters, and Cognitive Dysfunction ↙️ paper ↙️ advanced.onlinelibrary.wiley.com/doi/10.1002/... multisite & multiscale ↙️ by @kexie.bsky.social & a dream team 💫
Temporal Lobe Epilepsy Perturbs the Brain‐Wide Excitation‐Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction
Xie and colleagues apply advanced signal modeling and biophysical simulations to multimodal neuroimaging data in patients with temporal lobe epilepsy and healthy controls. They demonstrate robust inc...
advanced.onlinelibrary.wiley.com