Alex Gao
@algao.bsky.social
Assistant Professor of Biochemistry and Microbiology & Immunology at Stanford. Previously at MIT, Broad Institute, and Harvard Society of Fellows. Microbiology and biotech 🧬 https://gaolab.bio/
1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. doi.org/10.64898/202...
Great summary by @philipcball.bsky.social! Our findings certainly don’t invalidate the central dogma, but rather demonstrate an unexpected (and cool!) structural mechanism by which a sequence-specific DNA is created in a cell. (1/6)
Philip Ball@philipcball.bsky.social · 4mo agoFeels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment. So here's a 🧵. /1 www.science.org/doi/10.1126/...
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze! www.science.org/doi/10.1126/...
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