Alireza Mashaghi
@alirezamashaghi.bsky.social
Scientist, Physician, University Professor (UHD) at Leiden University, Scientist at Harvard, ETH Zürich Alumni; Views my own. Website: https://www.mashaghilab.org
Read our new article on biomolecular condensates! www.nature.com/articles/s41...
Optically driven control of mechanochemistry and fusion dynamics of biomolecular condensates via thymine dimerization - Nature Communications
Understanding and controlling phase-separated biomolecular condensate mechanochemistry is critical for their function and material properties. In this study, the authors developed assays that enable t...
nature.com
On our efforts to bridge disciplines for biomedical innovation! www.youtube.com/watch?v=-rlh... #ChemSky #MedSky #EngSky #PharmSky
The Mashaghi Lab: Bridging Disciplines for Biomedical Innovation
YouTube video by Alireza Mashaghi Lab
youtube.com
Als eerste ter wereld heeft het laboratorium van onderzoeker Alireza Mashaghi een quantum biosensor-installatie in gebruik genomen. Hiermee kunnen supersnelle en haast onzichtbare veranderingen in cellen worden waargenomen. Dat levert essentiële informatie op voor behandelingen van ziekten.
Eerste quantum biosensor ‘ziet’ razendsnelle veranderingen in cellen
Als eerste ter wereld heeft het laboratorium van Leids onderzoeker Alireza Mashaghi een quantum biosensor-installatie van QT-Sense in gebruik genomen. Hiermee kunnen supersnelle en haast onzichtbare v...
universiteitleiden.nl
Our quantum sensing research is featured on the front page of the Leiden University website today! Thanks to our team and collaborators for their dedication and contributions to this exciting work. www.universiteitleiden.nl/en/news/2026... #QuantumSensing #QuantumTechnology #ChemSky
Through a series of papers, we demonstrated the applicability of scanning probe microscopy to biomolecular condensate analysis! Droplet fusion: doi.org/10.1038/s414... Droplet rheology: doi.org/10.1016/j.xc... doi.org/10.1016/j.xp... Droplet-cell interaction: doi.org/10.1016/j.ce... #ChemSky #AFM
This week, we installed a first-of-its-kind quantum sensing platform in our lab! As part of our lab’s mission to advance #interdisciplinary research, we’re bringing #quantum sensing into #pharmacology. #ChemSky
With my team this Friday evening, concluding our lab work with an outing in the city!
Press release: Light switch for life – controlling biomolecular condensate droplets with UV! Read our new article in Nature Communications! www.universiteitleiden.nl/en/news/2026... #ChemSky #BiomolecularCondensate #SoftMatter #Protocell #Polyelectrolyte
Light switch for life: controlling molecular droplets with UV
Leiden researchers have discovered a surprising new way to shape and control tiny droplets of molecules found in living organisms. The breakthrough could lead to smarter biomaterials, improve drug del...
universiteitleiden.nl
A new study by Runfeng Lin & Sebastian Ahnerton from Cambridge University on the application of Circuit Topology in Protein Science: "Millisecond Prediction of Protein Contact Maps from Amino Acid Sequences" www.biorxiv.org/content/10.6... #ChemSky #Topology #StructuralBiology #Bioinformatics
Interest grows in #quantum physics for #biology. Sharing our early quantum calculations on #biomolecular structure, dynamics, and electrical properties: Interfacial water facilitates energy transfer by inducing extended vibrations in membrane lipids. pubs.acs.org/doi/10.1021/... #ChemSky
Interfacial Water Facilitates Energy Transfer by Inducing Extended Vibrations in Membrane Lipids
We report the complete assignment of the vibrational spectrum of dipalmitoylphosphatidylcholine (DPPC), which belongs to the most ubiquitous membrane phospholipid family, phosphatidylcholine. We find ...
pubs.acs.org
Delighted to share our new study, "Topological Investigation of Protein Folding and Intrinsic Disorder". We ask whether topology provides a unifying structural language across the order–disorder continuum! doi.org/10.64898/202... #ChemSky #Protein #IDP #Topology #Biophysics
My laboratory has an open postdoctoral position in the field of biomolecular condensate mechanochemistry! Please inquire if you are interested in interdisciplinary, cutting-edge research! www.mashaghilab.org/vacancies (Deadline: February 8, 2026) #ChemSky #Mechanobiology #Biomolecular_Condensate
Mashaghi Lab - Vacancies
Community science: Since 1996, Alireza Mashaghi has actively advocated for collaborations between disciplines to explore new ways of addressing scientific and societal challenges. The team has a long...
mashaghilab.org
RNA topology: from simple loops to complex circuits chemrxiv.org/engage/chemr... #ChemSky #RNA #Biophysics
Learning capacity and function of stochastic reaction networks iopscience.iop.org/article/10.1... #ChemSky #Network #Physics #Stochasticity #Learning
Impressive work by Dr. Jonas Berx and co-workers in the Journal of Chemical Physics on the topological organization of polymeric aggregates! doi.org/10.1063/5.02... #ChemSky #Topology #Polymer #Biophysics #SoftMatter
Interplay of coil–globule transitions and aggregation in homopolymer aqueous solutions: Simulation and topological insights
We investigate the structural and topological properties of hydrophobic homopolymer chains in aqueous solutions using molecular dynamics simulations and circuit
doi.org
Good luck, Tony! You have been an inspiration to many! Thank you! @hymanlab.bsky.social
EMBL@embl.org · 8mo agoAnthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...
On circuit topology of knots! Circuit topology for bottom-up engineering of molecular knots doi.org/10.3390/sym1... A tile model of circuit topology for entangled biopolymers www.nature.com/articles/s41... Polynomial invariant of molecular circuit topology doi.org/10.3390/sym1... #ChemSky #knot
Our protocol on "Scanning probe microscopy for rheological analysis of biomolecular condensates" is now available for interested users! doi.org/10.1016/j.xp... #ChemSky #Biphysics #Biomolecular_Condensates #IDP #Rheology #AFM
Vasily from our team was invited to present at the #NRRN meeting on “Conformational Dynamics and Chromatin Assembly of #Glucocorticoid Receptor Using Topological Modeling and Single-Molecule Analysis.” Looking forward to connecting with researchers on advances in nuclear receptor research. #ChemSky
We discovered that the "orphan" nuclear receptor Nur77 binds DNA under regulation by #glucocorticoid receptor & glucocorticoids. The synthetic glucocorticoid dexamethasone directly interacts with Nur77, revealing a new function for this drug & a potential ligand for Nur77. doi.org/10.1101/2025...
We’re excited to share our new #PyMOL plugin for protein topology analysis, now available! doi.org/10.1101/2025... Link to the report and the GitHub repository: We’d appreciate your feedback — please try it out in PyMOL and report any bugs or suggestions! #ChemSky #IDP #Topology #Bioinformatics
An interview with Stanford scientist Jonathan Chen on Medical #AI! Also, see the piece we co-authored on Statistical #Physics and its applications in #Medicine: pubmed.ncbi.nlm.nih.gov/33228143/
Statistical Physics for Medical Diagnostics: Learning, Inference, and Optimization Algorithms - PubMed
It is widely believed that cooperation between clinicians and machines may address many of the decisional fragilities intrinsic to current medical practice. However, the realization of this potential ...
pubmed.ncbi.nlm.nih.gov
NEJM AI@ai.nejm.org · 10mo agoIn the latest episode of the NEJM AI Grand Rounds podcast, Dr. Jonathan Chen discusses his path from teenage programmer to Stanford physician-informatician and why machine learning has both thrilled and unnerved him. Listen to the full episode: nejm.ai/ep35 #AI #MedSky
Our postdoctoral researcher Aida Naghilou presented our lab’s development of SPM-based technology for biomolecular condensate analysis at the Erwin Schrödinger Institute during the workshop “Charged Soft Matter: Bridging Theory and Experiment”! www.youtube.com/playlist?lis... #ChemSky #SoftMatter
We recently had some fun with protamine, which we used to model the Aggregate-to-Condensate transition in polyelectrolyte systems! pubs.acs.org/doi/10.1021/... #ChemSky #Bioengineering
Protamine Drives Liquid and Solid Condensation of DNA and Glycosaminoglycans
Phase-separated biomolecular condensates play a crucial role in cellular organization. In the nucleus, phase separation regulates the assembly and function of nuclear proteins and the genome. Here, we...
pubs.acs.org
We recently carried out the first single-molecule analysis of protein folding & unfolding in a cytosolic environment using optical tweezers—moving beyond simplistic buffer conditions to study proteins where they actually function. advanced.onlinelibrary.wiley.com/doi/10.1002/... #ChemSky #Biophysics
Cytosolic Interactome Protects Against Protein Unfolding in a Single Molecule Experiment
Single molecule experiments aimed at probing protein folding are typically performed in buffer conditions and cannot therefore be representative of the multi-faceted and complex cooperative interacti...
advanced.onlinelibrary.wiley.com
PhD student Vasily Akulov from our group is presenting our collaborative research with Eva Estébanez-Perpiñá’s group at the EMBO Workshop in Palermo, Italy! meetings.embo.org/event/25-str... #EMBO #StructuralBiology #IDP #Topology
On extracellular #biomolecular condensates! We demonstrate that phase-separated #condensate #droplets can form and function in the #extracellular environment and may interact with cells! www.sciencedirect.com/science/arti... #CellBiology #Biophysics #ChemicalEngineering #SyntheticBiology #ChemSky
