Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly

Many proteins contain intrinsically disordered regions (IDRs) that lack stable three-dimensional structure. IDR behavior is poorly understood, leading…

sciencedirect.com

Astral architecture can enhance mechanical strength of cytoskeletal networks by modulating percolation thresholds

A repeated pattern in cytoskeletal architecture is the aster, in which a number of F-actin filaments emerge star shaped from a central node. Aster-based structures occur in cytoplasmic actin, the earl...

cell.com

Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly

Many proteins contain intrinsically disordered regions (IDRs) that lack stable 3-dimensional structure. IDR behavior is poorly understood, leading to challenges for biochemical and computational analy...

biorxiv.org

Scalable inference and identifiability of kinetic parameters for transcriptional bursting from single cell data

AbstractMotivation. Stochastic gene expression and cell-to-cell heterogeneity have attracted increased interest in recent years, enabled by advances in sin

academic.oup.com

Nucleosome placement and polymer mechanics explain genomic contacts on 100 kb scales

Abstract. The 3D organization of the genome—in particular, which two regions of DNA are in contact with each other—plays a role in regulating gene expressi

academic.oup.com