We're proud to share the first YPIC led perspective article in the Journal of Proteomics: "Proteomics at scale: Bottlenecks and opportunities for early-career researchers in a fast developing field"

Such a beautiful work showcasing the usefulness of subcellular proteomics profiling to study oncogenic signaling. Check it out here: www.nature.com/articles/s41... It is great to see other groups benefiting from our subcellular fractionation protocol 👩🏻‍🔬🧫🔬 @jesperolsenlab.bsky.social

Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cells - Leukemia

Leukemia - Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cells

nature.com

Don’t miss our contribution to this conference at: Section 1 Estefanía Núñez and @diegomena00.bsky.social Section 2 Consuelo Marín-Vicente, Samuel Lozano and María Picos Section 4 @anamdv.bsky.social Section 6 David del Río Poster session 3 @inmajorgecerrudo.bsky.social and Emilio Camafeita

Como join us next Monday 11th at @cnicproteomics.bsky.social for a surely inspiring talk by @slavov-n.bsky.social ! #singlecell #proteomics

Nikolai Slavov@slavov-n.bsky.social · 3mo ago

Next Monday (May 11), I will be in Madrid to share our research. I will present results from @parallelsq.bsky.social and @slavovlab.bsky.social, including our latest proteomic technologies and the biological questions they are answering.

Huge congrats to @luciacg03.bsky.social for winning the EUPA Science Slam video competition hosted today at the #ECRday from @eupaproteomics.bsky.social with her tale about EVe. Check it out here: www.youtube.com/watch?v=ohwK...

Lucia Casado Garcia - 3 min Science Slam

YouTube video by Young proteomics investigators club YPIC

youtube.com

Last week, our youngest members shared their work at #APG2026, organized by @ypic.bsky.social. Special congratulations to Samuel, who won the Best Short Talk Award 🏆, and to @anamdv.bsky.social who is leaving YPIC after several years as the Spanish representative. #cardioproteomics

Less than one week for the Annual Proteomics Gathering 2026! I will be thrilled to welcome the new generation of proteomics scientists for a day full of science 🔬👩🏻‍🔬🎉

@ypic.bsky.social · 4mo ago

⏳ Just one week to go until the Annual Proteomics Gathering 2026 at the Faculty of Pharmacy, Universidad Complutense de Madrid!

⏰ Final Reminder: Registration Deadline for APG Networking Event Today! ⏰ APG attendees, join us at The Beer Temple (Calle Almansa 85, 28040 Madrid) on April 16th at 19:00! Celebrate & connect in a relaxed atmosphere post-APG. Scan QR code in flyer to confirm-deadline April 9th!

@ypic.bsky.social · 4mo ago

YPIC warmly invites all attendees of the Annual Proteomics Gathering to join our networking event at The Beer Temple, 16th April at 19:00 🍻 #AnnualProteomicsGathering #Networking #ScienceCommunity #YoungResearchers #InnovationInScience #FlashTalks #EarlyCareerResearchers #YPIC

I am thrilled to share the final programme for the upcoming Annual Proteomics Gathering organized by @ypic.bsky.social in Madrid. Check out the QR to see the full list of speakers and talks themes. It looks like a very promising event! 👩🏻‍🔬🔬🎓 Looking forward to welcome all the attendees on April 16th!

@ypic.bsky.social · 5mo ago

🚨 The final programme for the Annual Proteomics Gathering at the Faculty of Pharmacy, Universidad Complutense de Madrid on April 16th is officially ready! 🎉 #AnnualProteomicsGathering #Networking #ScienceCommunity #YoungResearchers #InnovationInScience #FlashTalks #EarlyCareerResearchers #YPIC

📢 Registration is now open for the Annual Proteomics Gathering, taking place on 16th April in Madrid. We look forward to welcoming you in Madrid! REGISTRATION LINK: docs.google.com/forms/d/e/1F...

First real end-to-end protocol on Wall-E🤖 Huge thanks to #EyownTechnologies and #Opentrons for the support. Goodbye manual pipetting😝😂

📣Today our colleague Samuel delivered an amazing seminar at the @eubic-ms.org Winter School 📣 He shared his single-cell analyses using a new workflow to study PTMs in DIA through open-search, called PTM-Beacon 💻🔍 Congrats!!

📢 Abstract Submission Now Open! This is your chance to showcase your research at the 3rd Annual Proteomics Gathering in Madrid! 🇪🇸🧬 Submit your abstract easily via the QR code or the link below: docs.google.com/forms/d/e/1F... #APG2026 #YPIC #Proteomics #EarlyCareerResearchers #EuPA

We are very happy to have collaborated with María José Fernández-Gómez and Nerea Méndez-Barbero from Patologia Vascular lab in IIS-FJD We’re proud to share that her poster was selected as the winner of the poster competition at #CNICPhDay! Congratulations to the whole team for this achievement! 🎉💡

Do you have an exciting experiment that you'd love to do using proteomics in the context of your work? YPIC funds 5000 eur for your research idea to come to life! ⬇️⬇️⬇️⬇️⬇️

@ypic.bsky.social · 11mo ago

🎉 Exciting opportunity for students in proteomics! 🎉 The Student Proteomics Fund (SPF) is back! 📅 Key dates: Call opens: October 1, 2025 Submission deadline: November 30, 2025 Don’t miss your chance to bring your research idea to life! New boost #SPF #YPIC #Proteomics

Sign up to our monthly newsletter and stay up to date with the latest developments of #TeamReSynBio mailchi.mp/resynbio/hup... In this edition #PACREDOX by @anamdv.bsky.social at CNIC Spain. pubs.acs.org/doi/10.1021/... Catch up with us @hupo-org.bsky.social 2025 in Toronto!

Thrilled to present my first work at CNIC published now at #AnalyticalChemistry @acs.org , showcasing a novel method to help streamline REDOX proteomics experiments by combining differential alkylation with PAC-based sample prep 🧲. Check it out: pubs.acs.org/doi/full/10....

Benchmark for Quantitative Global and Redox Proteomics Analysis by Combining Protein-Aggregation Capture and Data Independent Acquisition

Oxidative damage plays a critical role in various diseases including cardiovascular and neurological disorders. Thiol redox reactions, acting as oxidative stress sensors, influence protein structure a...

pubs.acs.org

CNIC Proteomics Lab@cnicproteomics.bsky.social · 11mo ago

📢 New paper out! Oxidative stress disrupts protein homeostasis and is linked to many diseases. To study this, REDOX proteomics is key—but until now, workflows haven’t been very accessible. 👇

📣📣It is great to finally welcome @cnicproteomics.bsky.social to Bluesky 🎊 Follow them if you want to learn about the latest development in PTM research applied to cardiovascular diseases! 🫀🧪🧫🖥️🛠️

Today at CNIC we had the pleasure to host @clairekoenig.bsky.social for her talk about "Proteins for the past". It sparked a lot of interest!

El pasado viernes, 6 de junio, realizamos por primera vez el workshop "Enseña tu técnica", en el cual participaron cinco jóvenes investigadores, deleitándonos con interesantes e innovadoras técnicas que llevan a cabo en su trabajo diario.

No perdáis la oportunidad de registraros en la 1ª edición de “Enseña tú técnica”, en la cual, jóvenes investigadores con gran motivación, nos ilustrarán con diversidad de herramientas en las que están especializados. ¡Os esperamos!

📣 Thrilled to announce that my latest work during my postdoc at @jesperolsenlab.bsky.social is finally published! Check out our quantitative proteomics analysis on a premetastatic colorectal cancer cohort, and how we identify potential biomarkers to assess risk relapse.

JesperOlsenLab@jesperolsenlab.bsky.social · last yr.

🚨 Check out our new study on proteomic profiling in premetastatic colorectal cancer! Accross 412 tumors, we define molecular subtypes with distinct functional landscapes and revealed CAVIN1 as novel biomarkers for relapse risk. www.embopress.org/doi/full/10....

Relocating for science? You're not alone! Join us in our new podcast episode sharing inspiring stories and diverse perspectives on moving and thriving in science. Let's learn from each other! open.spotify.com/show/7EmOcPU...

NextGen Proteomics

Podcast · YPIC · Proteomics, self development, and much more!

open.spotify.com

🌟 Happy Women and Girls in Science Day! 🌟 Science thrives on diversity and curiosity—let’s celebrate the brilliant minds shaping the future! 🔬🚀💡 #WomenInScience #February11 #Science

@eupaproteomics.bsky.social · last yr.

Happy Women and Girls in Science Day! 🥳 Discover groundbreaking insights from @kathrynslilley.bsky.social and Paola Picotti—two remarkable leaders in sub-cellular proteomics and LiP-MS! 🎥 Watch their inspiring videos here: youtu.be/5fYcQyJPCzE?... and youtu.be/3kS6tB8WfmA?.... #February11 #Science

📣📣First post for many things: 1st one in bluesky and 1st one of my work since joining CNIC! Preprint for our novel implementation of PAC and DIA for REDOX proteomics, with application to cardiovascular diseases♥️🐖🔬. Check it out in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Protein aggregation capture assisted profiling of the thiol redox proteome

Oxidative damage is critical in various diseases, including cardiovascular and neurological conditions. Thiol redox reactions, acting as oxidative stress sensors, influence protein structure and function. Redox proteomics based on differential alkylation of reduced and oxidized Cys forms using mass spectrometry enables comprehensive analysis of thiol redox status in cells and tissues. We introduce PACREDOX, an innovative redox proteomics approach based on the Protein Aggregation Capture (PAC) protocol and we demonstrate its compatibility with library free data-independent acquisition (DIA). PACREDOX reduces preparation time and costs compared to traditional methods, such as FASILOX, while maintaining thiol and proteome coverage. To enable library-free DIA, we corrected in silico spectral libraries in DIA-NN using experimental retention time data from beta-methylthiol-modified peptides. PACREDOX with DIA quantified 4,000 protein groups and ~45,000 modified peptides in myocardial tissue from a porcine model of atrial fibrillation, including over 8,000 cysteine-containing peptides, 30% of which were reversibly oxidized. Benchmarking PACREDOX and DIA against FASILOX in a myocardial infarction model reflects the potential and efficiency of this methodology to study oxidative damage. Overall, PACREDOX offers a high-throughput, cost-effective strategy for thiol redox proteome analysis, compatible with label-free quantitative workflows. ### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org